INT48911

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Context Info
Confidence 0.40
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 11.21
Pain Relevance 5.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
neuronal 4
skeletal muscle 2
trigeminal ganglia 2
subpallium 1
platelets 1
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 54 100.00 Very High Very High Very High
substance P 41 100.00 Very High Very High Very High
Calcitonin gene-related peptide 14 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 12 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
gABA 127 99.80 Very High Very High Very High
aspirin 4 99.42 Very High Very High Very High
Opioid 8 99.30 Very High Very High Very High
nMDA receptor 80 99.04 Very High Very High Very High
Glutamate 89 98.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Appetite Loss 92 100.00 Very High Very High Very High
Eating Disorder 80 100.00 Very High Very High Very High
Dementia 5 99.72 Very High Very High Very High
Stress 427 99.44 Very High Very High Very High
Enteropathy 2 99.16 Very High Very High Very High
Diabetes Mellitus 123 98.68 Very High Very High Very High
Adhesions 16 97.96 Very High Very High Very High
Toxicity 8 97.92 Very High Very High Very High
Myocardial Infarction 3 97.88 Very High Very High Very High
Nicotine Addiction 7 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NOS were also shown to be associated with a plethora of more than 20 proteins that affect the activity and spatial organization of NO synthesis within the cell.
NOS Binding (associated) of
1) Confidence 0.40 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1180462 Disease Relevance 0.68 Pain Relevance 0.04
In order to determine which 5-HT(1) receptor subtypes are involved we have by immunocytochemistry examined the distribution of 5-HT(1B) and 5-HT(1D) receptors in the human trigeminal ganglia, and addressed which of them colocalize with calcitonin gene-related peptide (CGRP), substance P (SP) or nitric oxide synthase (NOS).
nitric oxide synthase Binding (colocalize) of in trigeminal ganglia associated with substance p and calcitonin gene-related peptide
2) Confidence 0.37 Published 2001 Journal Brain Res. Section Abstract Doc Link 11478927 Disease Relevance 0.25 Pain Relevance 0.56
In order to determine which 5-HT(1) receptor subtypes are involved we have by immunocytochemistry examined the distribution of 5-HT(1B) and 5-HT(1D) receptors in the human trigeminal ganglia, and addressed which of them colocalize with calcitonin gene-related peptide (CGRP), substance P (SP) or nitric oxide synthase (NOS).
NOS Binding (colocalize) of in trigeminal ganglia associated with substance p and calcitonin gene-related peptide
3) Confidence 0.37 Published 2001 Journal Brain Res. Section Abstract Doc Link 11478927 Disease Relevance 0.25 Pain Relevance 0.56
The latter is also associated with loss of nNOS and TH expression but by contrast, presents with increased expression of SP [26], suggesting regional variations in the effects of diabetes on the enteric nervous system.
nNOS Binding (associated) of in enteric nervous system associated with diabetes mellitus and substance p
4) Confidence 0.35 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.71 Pain Relevance 0.12
Indeed, NOS bears striking homology to CYP450 (Bredt et al 1991), while KCZ binding to the heme structure within NOS has been found to reduce the maximal velocity of the enzyme (Wolff et al 1993).
NOS Binding (binding) of
5) Confidence 0.34 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.56 Pain Relevance 0.07
In normal skeletal muscle, nNOS is located at the cell membrane bound to the cytoskeletal protein dystrophin (Brenman et al. 1995, Chang et al. 1996).
nNOS Binding (bound) of in skeletal muscle
6) Confidence 0.33 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.30 Pain Relevance 0.32
Skeletal muscle may be an additional source of nNOS-derived NO with important influences on vascular tone.
nNOS-derived NO Binding (source) of in Skeletal muscle
7) Confidence 0.33 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.28 Pain Relevance 0.32
The functional association between vascular nNOS and eNOS with respect to the regulation of tone and how this may be altered in disease settings also requires further study.
nNOS Binding (association) of associated with disease
8) Confidence 0.33 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.37 Pain Relevance 0.05
L-NAME significantly reduces the immunoreactivity for NOS.
NOS Binding (immunoreactivity) of
9) Confidence 0.31 Published 2000 Journal Cornea Section Body Doc Link 10632015 Disease Relevance 0.05 Pain Relevance 0
No significant changes were seen with the SP antibody but immunolabeling for nNOS, H02 (Figure 2) and TH (Figure 1) was decreased (by 40–50%) in the patient with poorly controlled diabetes.



nNOS Binding (immunolabeling) of associated with diabetes mellitus and substance p
10) Confidence 0.31 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.23 Pain Relevance 0.22
Analysis of this interaction revealed that opioids modify the dimeric active form of NOS, through binding to the reductase part of the molecule, acting as non-competitive inhibitors of the enzyme.
NOS Binding (binding) of associated with opioid
11) Confidence 0.30 Published 2001 Journal Cell Death Differ. Section Abstract Doc Link 11526449 Disease Relevance 0.23 Pain Relevance 0.77
causes nitrite to accumulate in rat ovarian dispersates, demonstrating the close interaction between cytokines and NOS [76].
NOS Binding (interaction) of associated with cytokine
12) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 1.15 Pain Relevance 0.35
The decrease in NMDA receptor density following TDS stress (Harvey et al 2004) further underlines the involvement of iNOS and not nNOS, since iNOS activation is not regulated by neuronal receptors (McCaslin and Oh 1995).


nNOS Binding (involvement) of in neuronal associated with stress and nmda receptor
13) Confidence 0.26 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.93 Pain Relevance 0.24
These results indicate the existence of different types of NADPH-d, which are associated or not associated with nitric oxide synthase(s), and which are differently influenced by various fixation procedures in rat and human pancreas.
oxide synthase Binding (associated) of in pancreas
14) Confidence 0.23 Published 1994 Journal Histochemistry Section Abstract Doc Link 7532638 Disease Relevance 0.07 Pain Relevance 0.04
The aim of the present study was to determine the mechanism by which aspirin acutely increases the activity of NO synthase type 3 (NOS-3), the predominant NOS isoform expressed by platelets, and specifically whether this occurs through an increase in its acetylation.
NOS Binding (activity) of in platelets associated with aspirin
15) Confidence 0.11 Published 2009 Journal Cardiovasc. Res. Section Abstract Doc Link 19377066 Disease Relevance 0.10 Pain Relevance 0.23
ONOO- can also interact with mitochondria, reaching them from extra-mithocondrial compartments or being locally produced through the interaction of NO (generated by the mitochondrial NOS) and O2•-.
NOS Neg (NO) Binding (interaction) of
16) Confidence 0.10 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.66 Pain Relevance 0.03
Glutamate binding to the N-methyl-d-aspartate (NMDA) receptor results in calcium (Ca2+) influx, which binds to calmodulin and activates nitric oxide synthase (NOS).
NOS Binding (binds) of associated with glutamate
17) Confidence 0.09 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704618 Disease Relevance 0.06 Pain Relevance 0.47
Activation of NMDA receptors results in calcium influx into the cell, which binds to calmodulin and activates neuronal nitric oxide (NO) synthase (NOS), thereby increasing intracellular NO concentrations.
NOS Binding (binds) of in neuronal associated with nmda receptor
18) Confidence 0.09 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704618 Disease Relevance 0.36 Pain Relevance 0.37
This antibody recognizes neuronal NOS using Western blotting and the immunoreactivity is abolished by absorption of the K205 antiserum with recombinant neuronal NOS protein (1?
NOS Binding (recognizes) of in neuronal
19) Confidence 0.06 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0
The cholinergic innervation of the adrenal gland and its relation to enkephalin and nitric oxide synthase.
nitric oxide synthase Binding (relation) of in adrenal gland associated with enkephalin
20) Confidence 0.06 Published 1995 Journal Neuroreport Section Title Doc Link 8741766 Disease Relevance 0.15 Pain Relevance 0.47

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