INT48912

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Context Info
Confidence 0.77
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 52
Total Number 53
Disease Relevance 24.14
Pain Relevance 10.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
nerve 5
brain 4
Skeletal muscle 3
trigeminal ganglion 3
lung 3
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 87 100.00 Very High Very High Very High
substance P 43 100.00 Very High Very High Very High
Calcitonin gene-related peptide 22 100.00 Very High Very High Very High
Dopamine 19 100.00 Very High Very High Very High
Neuropeptide 16 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 9 100.00 Very High Very High Very High
Catecholamine 6 100.00 Very High Very High Very High
trigeminal ganglion 10 99.96 Very High Very High Very High
orphanin 20 99.92 Very High Very High Very High
nMDA receptor 90 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 347 100.00 Very High Very High Very High
Appetite Loss 92 100.00 Very High Very High Very High
Ganglion Cysts 27 99.96 Very High Very High Very High
Targeted Disruption 42 99.62 Very High Very High Very High
INFLAMMATION 320 99.52 Very High Very High Very High
Cv General 4 Under Development 6 99.42 Very High Very High Very High
Eating Disorder 80 99.18 Very High Very High Very High
Rhinitis 252 98.96 Very High Very High Very High
Panic Disorder 9 98.82 Very High Very High Very High
Apoptosis 44 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localization of nitric oxide synthase and haemoxygenase, and functional effects of nitric oxide and carbon monoxide in the pig and human intravesical ureter.
Localization (Localization) of nitric oxide synthase in ureter
1) Confidence 0.77 Published 1997 Journal Neurourol. Urodyn. Section Title Doc Link 9136143 Disease Relevance 0 Pain Relevance 0.03
Histochemical observation of nitric oxide synthase in trigeminal ganglion of rats with experimental pulpitis.
Localization (observation) of nitric oxide synthase in trigeminal ganglion associated with ganglion cysts, nociceptor, pulpitis and trigeminal ganglion
2) Confidence 0.73 Published 1999 Journal J. Tongji Med. Univ. Section Title Doc Link 12840884 Disease Relevance 0.80 Pain Relevance 0.63
We determined the localization of nitric oxide synthase and the target enzyme of NO, soluble guanylyl cyclase, in the human bladder.
Localization (localization) of nitric oxide synthase in bladder
3) Confidence 0.72 Published 2001 Journal J. Urol. Section Abstract Doc Link 11342964 Disease Relevance 0 Pain Relevance 0.10
Localization of constitutive nitric oxide synthase isoforms and the nitric oxide target enzyme soluble guanylyl cyclase in the human bladder.
Localization (Localization) of nitric oxide synthase in bladder
4) Confidence 0.72 Published 2001 Journal J. Urol. Section Title Doc Link 11342964 Disease Relevance 0 Pain Relevance 0.08
Taken together, these observations suggest that nNOS-derived NO released from capsaicin-sensitive sensory nerve fibers may presynaptically modulate adrenergic sympathetic neurotransmission and hence vascular tone.
Localization (released) of nNOS-derived NO in sensory nerve associated with qutenza
5) Confidence 0.70 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.20 Pain Relevance 0.33
Consistent with this idea, immunostaining of mesenteric artery specimens localized nNOS to perivascular capsaicin-sensitive sensory nerve fibers, whereas the functional depletion of nNOS-immunopositive fibers with capsaicin abolished the augmented vasoconstrictor response to nerve stimulation (Hatanaka et al. 2006).
Localization (localized) of nNOS in nerve associated with qutenza
6) Confidence 0.70 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.14 Pain Relevance 0.32
5-HT(1B) and 5-HT(1D) receptors in the human trigeminal ganglion: co-localization with calcitonin gene-related peptide, substance P and nitric oxide synthase.
Localization (co-localization) of nitric oxide synthase in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion, substance p and calcitonin gene-related peptide
7) Confidence 0.69 Published 2001 Journal Brain Res. Section Title Doc Link 11478927 Disease Relevance 0.29 Pain Relevance 0.61
In conclusion, both 5-HT(1B) and 5-HT(1D) receptors are expressed in the human trigeminal ganglion and they are mainly localized in medium-sized cells and they seem to colocalize with CGRP, SP and NOS.
Localization (colocalize) of NOS in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion, substance p and calcitonin gene-related peptide
8) Confidence 0.64 Published 2001 Journal Brain Res. Section Abstract Doc Link 11478927 Disease Relevance 0.17 Pain Relevance 0.58
Skeletal muscle expresses all three forms of NOS, with nNOS predominating.
Localization (predominating) of NOS in Skeletal muscle
9) Confidence 0.63 Published 2004 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129157 Disease Relevance 0 Pain Relevance 0
Skeletal muscle expresses all three forms of NOS, with nNOS predominating.
Localization (predominating) of nNOS in Skeletal muscle
10) Confidence 0.63 Published 2004 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129157 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry was used to localize isoforms of NOS that might generate NO.
Localization (localize) of NOS
11) Confidence 0.59 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9751155 Disease Relevance 1.01 Pain Relevance 0.56
In addition to endothelial nitric oxide synthase expression, detrusor smooth muscle was recognized as an important location of endothelial nitric oxide synthase, while the urothelium had only small endothelial nitric oxide synthase positive cell clusters.
Localization (location) of nitric oxide synthase in smooth muscle
12) Confidence 0.58 Published 2001 Journal J. Urol. Section Body Doc Link 11342964 Disease Relevance 0.06 Pain Relevance 0
Nociceptin is colocalized with CGRP, SP, NOS and PACAP.
Localization (colocalized) of NOS associated with orphanin, substance p and calcitonin gene-related peptide
13) Confidence 0.58 Published 2003 Journal Brain Res. Section Abstract Doc Link 12576178 Disease Relevance 0.14 Pain Relevance 0.94
Methylene blue, a guanylate cyclase and NOS
Localization (cyclase) of NOS
14) Confidence 0.58 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.76 Pain Relevance 0.43
NO via nNOS is increased after acute stress (Krukoff and Khalilli 1997; De Oliviera et al 2000) where NO acts predominantly as a neuromodulator by decreasing glutamate release, NO release, NOS activity, and increasing GABA release (see Figure 1 for detailed description) (Harvey 1996; Prast and Philippu 2001).
Localization (release) of NOS associated with stress, gaba and glutamate
15) Confidence 0.57 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.85 Pain Relevance 0.19
In addition, acute release of NO via nNOS and NMDA receptor activation down-regulates the NMDA receptor, while localized release of 5HT will attenuate the mobilization of Ca2+, NO, and cGMP (Marcoli et al 1997; Maura et al 2000).
Localization (release) of nNOS associated with nmda receptor and 5ht
16) Confidence 0.57 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.81 Pain Relevance 0.50
Moreover, the synaptic localization of NOS and the soluble guanylyl cyclase (McLeod et al 2001) facilitates the functioning of NO as a retrograde messenger – and thereby serves as a possible modulator of long-term potentiation (LTP) (Burette et al 2002).
Localization (localization) of NOS associated with long-term potentiation
17) Confidence 0.57 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.77 Pain Relevance 0.38
Effect of NO donors and NOS inhibitors on db-cAMP-stimulated gastric acid secretion
Localization (secretion) of NOS
18) Confidence 0.55 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC514546 Disease Relevance 0 Pain Relevance 0
Similar to results obtained in a study of isolated rabbit gastric glands[15], we found that the NOS inhibitors L-NAME and L-NNA, but not D-NAME, amplified the secretion-stimulating effect of histamine, which further indicates that the isolated human glands we used contained the enzyme NOS.
Localization (secretion) of NOS in glands
19) Confidence 0.55 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC514546 Disease Relevance 0 Pain Relevance 0
It is mobilized by phospholipases, especially cytoplasmatic phospholipase A2, and is metabolized by constitutive cyclooxygenase (COX-1) and inducible COX-2 into prostaglandins and related compounds, by lipooxygenase into leukotrienes and by p450 into epoxieicosanoid acids[10].
Localization (metabolized) of constitutive cyclooxygenase
20) Confidence 0.51 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0 Pain Relevance 0

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