INT4892

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 56
Total Number 57
Disease Relevance 25.64
Pain Relevance 34.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
neurons 17
dorsal root ganglion 14
spinal cord 13
dorsal horn 8
lymphocytes 6
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 655 100.00 Very High Very High Very High
dorsal root ganglion 442 100.00 Very High Very High Very High
Spinal cord 294 100.00 Very High Very High Very High
Inflammation 290 100.00 Very High Very High Very High
Pain 245 100.00 Very High Very High Very High
Kinase C 179 100.00 Very High Very High Very High
Dorsal horn 158 100.00 Very High Very High Very High
tetrodotoxin 68 100.00 Very High Very High Very High
Thalamus 62 100.00 Very High Very High Very High
agonist 61 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 451 100.00 Very High Very High Very High
Nociception 349 100.00 Very High Very High Very High
Respiratory Syncytial Virus 41 99.98 Very High Very High Very High
Inflammatory Pain 43 99.68 Very High Very High Very High
Abdominal Pain 1 99.66 Very High Very High Very High
INFLAMMATION 262 99.54 Very High Very High Very High
Arthritis 171 99.38 Very High Very High Very High
Vibrio Infection 45 99.32 Very High Very High Very High
Pain 279 99.24 Very High Very High Very High
Diverticulitis 1 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the neurokinin-1 receptor by substance P during chronic nociception increases neurokinin-1 receptor gene expression in the spinal cord.
Positive_regulation (increases) of Gene_expression (expression) of neurokinin-1 receptor in spinal cord associated with nociception, spinal cord and substance p
1) Confidence 0.69 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430499 Disease Relevance 0.42 Pain Relevance 0.46
The results showed that hind paw inflammation induced a significant increase of NK-1 receptor expression in the spinal dorsal horn and that this effect was significantly suppressed by EA.
Positive_regulation (increase) of Gene_expression (expression) of NK-1 receptor in paw associated with inflammation, spinal dorsal horn and electroacupuncture
2) Confidence 0.69 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15908113 Disease Relevance 0.81 Pain Relevance 1.03
Previous work has demonstrated that persistent nociception evokes increased neurokinin-1 receptor (NK-1) gene expression in the spinal cord dorsal horn of the rat within 2 h but has failed to elucidate the relationship between increased NK-1 gene expression at later time points and functional regulation of NK-1 receptor signaling.
Positive_regulation (increased) of Gene_expression (expression) of neurokinin-1 receptor in spinal cord dorsal horn associated with nociception, dorsal horn and spinal cord
3) Confidence 0.65 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15985614 Disease Relevance 0.32 Pain Relevance 0.27
In addition, after chronic administration baclofen was no longer capable of inducing analgesia or of inhibiting the increased expression of NK-1R mRNA and CGP 44532 was still fully effective in both regards.
Positive_regulation (increased) of Gene_expression (expression) of NK-1R mRNA associated with analgesia
4) Confidence 0.65 Published 1998 Journal Life Sci. Section Abstract Doc Link 9585130 Disease Relevance 0.39 Pain Relevance 1.04
Upregulation of neurokinin-1 receptor expression in rat spinal cord by an N-terminal metabolite of substance P.
Positive_regulation (Upregulation) of Gene_expression (expression) of neurokinin-1 in spinal cord associated with qutenza, substance p and spinal cord
5) Confidence 0.63 Published 2002 Journal Eur. J. Neurosci. Section Title Doc Link 12169105 Disease Relevance 0.36 Pain Relevance 1.72
Thus, SP metabolites, at times and doses that are antinociceptive, appear to enhance SP-mediated signal transduction by upregulating NK-1 receptor expression without affecting SP synthesis.
Positive_regulation (upregulating) of Gene_expression (expression) of NK-1 receptor associated with antinociceptive and substance p
6) Confidence 0.63 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12169105 Disease Relevance 0 Pain Relevance 1.43
The neurokinin-1 receptor antagonist LY306,740 blocks nociception-induced increases in dorsal horn neurokinin-1 receptor gene expression.
Positive_regulation (increases) of Gene_expression (expression) of neurokinin-1 receptor in dorsal horn associated with nociception, nociceptor, antagonist and dorsal horn
7) Confidence 0.61 Published 1996 Journal Mol. Pharmacol. Section Title Doc Link 8913350 Disease Relevance 0.26 Pain Relevance 0.43
Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs.
Positive_regulation (upregulates) of Gene_expression (expression) of substance P in lungs associated with respiratory syncytial virus and substance p
8) Confidence 0.60 Published 1999 Journal Am. J. Physiol. Section Title Doc Link 10516226 Disease Relevance 0.86 Pain Relevance 0.56
This implies a considerable upregulation of NK1 receptor synthesis in the dorsal root ganglia with subsequent transport to peripheral nociceptive terminals.
Positive_regulation (upregulation) of Gene_expression (synthesis) of NK1 receptor in dorsal root ganglia associated with nociception
9) Confidence 0.60 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12052531 Disease Relevance 0.43 Pain Relevance 0.58
DE inhalation affected the SP signaling processes, including stored SP depletion and the gene/protein overexpression for neurokinin-1 receptor.
Positive_regulation (overexpression) of Gene_expression (overexpression) of neurokinin-1 receptor associated with substance p
10) Confidence 0.58 Published 2003 Journal Arch. Toxicol. Section Abstract Doc Link 13680092 Disease Relevance 0.50 Pain Relevance 0.83
Although zymosan-induced colorectal inflammation alone did not induce SPR internalization in lamina I neurons, there was an increased number of SPR-expressing lamina I neurons showing SPR internalization in segments T12 through S2 of the spinal cord after colorectal distention.
Positive_regulation (increased) of Gene_expression (expressing) of SPR in spinal cord associated with inflammation and spinal cord
11) Confidence 0.50 Published 2002 Journal J Pain Section Abstract Doc Link 14622848 Disease Relevance 0.62 Pain Relevance 0.50
Electroacupuncture suppresses spinal expression of neurokinin-1 receptors induced by persistent inflammation in rats.
Positive_regulation (induced) of Gene_expression (expression) of neurokinin-1 in spinal associated with inflammation and electroacupuncture
12) Confidence 0.50 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15908113 Disease Relevance 0.78 Pain Relevance 1.14
These observations are discussed in the light of other recent studies indicating a central role for lamina I neurons expressing neurokinin 1 in the perception of severe pain.
Positive_regulation (role) of Gene_expression (expressing) of neurokinin 1 in neurons associated with pain
13) Confidence 0.47 Published 2000 Journal Neuroscience Section Abstract Doc Link 10799765 Disease Relevance 0.10 Pain Relevance 0.10
The present study was to explore whether activation of peripheral NK-1 receptor, especially expressed on primary sensory afferents, could induce hyperalgesia and sensitize C-type sensory afferents. (1) Intraplantar administration of NK-1 agonist [Sar9, Met(O2)11]SP (Sar-SP, 0.2, 1 nmol, 20 microl) produced significant thermal hyperalgesia and edema, which was blocked by co-injection of NK-1 antagonist WIN51,708 (10 nmol).
Positive_regulation (activation) of Gene_expression (expressed) of NK-1 receptor associated with pressure and volume under development, hyperalgesia, antagonist, thermal hyperalgesia and agonist
14) Confidence 0.46 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16300741 Disease Relevance 0.59 Pain Relevance 0.42
The results suggest that some of the single SPR expressing neurons in the medullary dorsal horn might be innervated by substance P containing primary afferent fibers and transmit sensory information diffusely to bilateral parabrachial nuclei by way of their axonal collaterals.
Spec (might) Positive_regulation (innervated) of Gene_expression (expressing) of SPR in neurons associated with primary afferent fibers, dorsal horn, parabrachial and substance p
15) Confidence 0.42 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 11044592 Disease Relevance 0 Pain Relevance 0.47
These results show that acute noxious visceral stimuli induce activation of spinal lamina I neurons expressing the SPR and, that after visceral inflammation, there is a marked increase in both the number and rostrocaudal extent of lamina I SPR neurons activated in response to both normally non-noxious and noxious distention of the colon.
Positive_regulation (induce) of Gene_expression (expressing) of SPR in visceral associated with inflammation
16) Confidence 0.41 Published 2002 Journal J Pain Section Abstract Doc Link 14622848 Disease Relevance 0.60 Pain Relevance 0.48
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Positive_regulation (induced) of Gene_expression (expression) of neurokinin receptor in ganglia associated with pain, opiate and spinal cord
17) Confidence 0.37 Published 1995 Journal Neuroscience Section Title Doc Link 7536308 Disease Relevance 0.38 Pain Relevance 0.93
Excitotoxic spinal injury resulted in: (1) increased phosphorylation of ERK1/2; (2) increased activation of NF-kB and phosphorylation of ELK-1; and (3) increased gene expression for the NK-1 receptor and NR1 and NR-2A subunits of the NMDA receptor.
Positive_regulation (increased) of Gene_expression (expression) of NK-1 receptor in spinal associated with nmda receptor and spinal injuries
18) Confidence 0.37 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15922485 Disease Relevance 0.68 Pain Relevance 0.43
Exposure of rats to DE affected the SP signaling pathway as indicated by overexpression of the NK1 receptor or reduction of SP in the lung tissue.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NK1 receptor in lung associated with substance p
19) Confidence 0.36 Published 2005 Journal Res Rep Health Eff Inst Section Abstract Doc Link 15916011 Disease Relevance 0.74 Pain Relevance 0.63
RESULTS: The expressions of SP mRNA, NK-1 R, GFAP, TNF-alpha and iNOS in the posterior horn of the L5 - S2 spinal cord were obviously higher in the rat prostatitis pain models than in the controls, successively higher at 28 than at 14 and 0 d (P < 0.01), and so was the expression of GFAP at 28 than at 14 d in the experiment groups (P < 0.05).
Positive_regulation (higher) of Gene_expression (expressions) of NK-1 R in spinal cord
20) Confidence 0.30 Published 2009 Journal Zhonghua Nan Ke Xue Section Body Doc Link 20218316 Disease Relevance 0 Pain Relevance 0

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