INT48920

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 107
Total Number 110
Disease Relevance 43.60
Pain Relevance 51.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
lung 6
spinal cord 3
bladder 3
neurons 3
visceral 2
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 127 100.00 Very High Very High Very High
Morphine 88 100.00 Very High Very High Very High
Anterior cingulate cortex 84 100.00 Very High Very High Very High
Glutamate 53 100.00 Very High Very High Very High
adenocard 38 100.00 Very High Very High Very High
Analgesic 36 100.00 Very High Very High Very High
Rostral ventromedial medulla 168 99.98 Very High Very High Very High
Ventral tegmentum 10 99.98 Very High Very High Very High
nMDA receptor 619 99.92 Very High Very High Very High
aspirin 11 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 312 99.80 Very High Very High Very High
Stress 115 99.70 Very High Very High Very High
Injury 272 99.64 Very High Very High Very High
Depression 24 99.60 Very High Very High Very High
Nociception 231 99.52 Very High Very High Very High
Necrosis 58 99.48 Very High Very High Very High
Pneumonia 49 99.42 Very High Very High Very High
Ganglion Cysts 176 99.32 Very High Very High Very High
Pain 1125 99.20 Very High Very High Very High
Hyperalgesia 135 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding may indicate that ERK inhibition might prove to be a good therapeutic strategy, at least for the treatment of bladder dysfunction.


Negative_regulation (inhibition) of ERK in bladder
1) Confidence 0.57 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.50 Pain Relevance 0.38
The activated Erk level in the ACC was reduced at 45 min and declined at 90 min after formalin injection.
Negative_regulation (reduced) of Erk associated with anterior cingulate cortex
2) Confidence 0.57 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.50 Pain Relevance 0.44
The activated Erk level in the ACC was reduced at 45 min and declined at 90 min after formalin injection.
Negative_regulation (declined) of Erk associated with anterior cingulate cortex
3) Confidence 0.57 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.50 Pain Relevance 0.44
Spontaneous nociceptive behaviours (SNBs), mechanical allodynia (von Frey thresholds) and heat hyperalgesia (plantar test latencies) induced by DHPG were measured in animals pretreated i.t. with membrane permeable inhibitors of ERK (PD 98059) and PKC (GF 109203X).
Negative_regulation (inhibitors) of ERK associated with nociception, kinase c, hyperalgesia and allodynia
4) Confidence 0.56 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 17030432 Disease Relevance 0.94 Pain Relevance 1.16
Although reductions in pERK levels were evident after 6 days of morphine administration, no differences were observed in pERK levels after 10 days.
Negative_regulation (reductions) of pERK associated with morphine
5) Confidence 0.55 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 1.19
The reduction of ERK 1/2 function herein reported may be associated with the therapeutic effects of fluoxetine in the treatment of depression.
Negative_regulation (reduction) of ERK associated with depression and fluoxetine
6) Confidence 0.54 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15935071 Disease Relevance 0.34 Pain Relevance 0.59
However, given the high basal levels of pERK reported here, it is unlikely that direct injections of ERK inhibitors into the RVM would resolve this issue.
Negative_regulation (inhibitors) of ERK associated with rostral ventromedial medulla
7) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.70 Pain Relevance 1.09
Another challenge is to explain how opioid receptor blockade in the vlPAG might regulate neural activity in such a way that it prevents ERK activity in the amygdala and mPFC.
Negative_regulation (prevents) of ERK in amygdala associated with opioid receptor and amygdala
8) Confidence 0.51 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.14 Pain Relevance 0.62
Inhibition of ERK with the selective MEK-1 antagonist, PD 098059 during IPC or TAN-67 administration significantly reduced cardioprotection (41.5 +/- 6.4 and 63.0 +/- 4.8).
Negative_regulation (Inhibition) of ERK associated with antagonist
9) Confidence 0.50 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11160653 Disease Relevance 0.16 Pain Relevance 0.39
On the other hand, the chronic restraint stress significantly decreased p-ERK-IR in the LC [P<0.05].
Negative_regulation (decreased) of ERK associated with stress and locus ceruleus
10) Confidence 0.50 Published 2004 Journal Pain Section Abstract Doc Link 15561392 Disease Relevance 0.72 Pain Relevance 0.93
We found that high frequency (0.5 Hz and 10 Hz) but not low frequent (0.05 Hz) stimulus-evoked pERK was partially inhibited by MK-801.
Negative_regulation (inhibited) of pERK
11) Confidence 0.49 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1941723 Disease Relevance 0 Pain Relevance 0.66
We used a membrane-permeable selective inhibitor of ERK activation (U0126) and its inactive structural analogue (U0124, see below) [52].
Negative_regulation (inhibitor) of ERK
12) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.31 Pain Relevance 0.45
More recent studies showed ERK activation and antinociceptive effects of ERK inhibition in the spinal cord in several pain models [reviewed by [35]].
Negative_regulation (inhibition) of ERK in spinal cord associated with pain, antinociceptive and spinal cord
13) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.49 Pain Relevance 0.95
Consequently, inhibitors of PKA and ERK, but not PKC, in the CeLC decrease supraspinally (vocalizations) and spinally (withdrawal reflexes) organized pain behaviors in animals with arthritis but not in normal animals.
Negative_regulation (inhibitors) of ERK associated with pain, withdrawal, amygdala and arthritis
14) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.68 Pain Relevance 0.87
Microinjection of U0126, a mitogen-activated protein kinase kinase inhibitor, into the RVM decreased phosphorylated ERK at 7 h after complete Freund's adjuvant (CFA) injection into the hindpaw.
Negative_regulation (decreased) of ERK in RVM associated with rostral ventromedial medulla
15) Confidence 0.48 Published 2008 Journal Brain Res. Section Abstract Doc Link 18037394 Disease Relevance 0.52 Pain Relevance 0.74
Our data demonstrate that 3-week fluoxetine treatment resulted in long-lasting reduction of phospho-ERK 1 and 2.
Negative_regulation (reduction) of ERK associated with fluoxetine
16) Confidence 0.47 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15935071 Disease Relevance 0.15 Pain Relevance 0.44
Administration of the P2X3 receptor antagonists, pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid or 2'- (or 3')-O-(trinitrophenyl)adenosine 5'-triphosphate (TNP-ATP), significantly decreased the mechanical stimulation-evoked pERK labeling in CFA-inflamed rats, but not in normal rats.
Negative_regulation (decreased) of pERK associated with adenocard and antagonist
17) Confidence 0.45 Published 2004 Journal Pain Section Abstract Doc Link 15030945 Disease Relevance 0.33 Pain Relevance 0.34
Moreover phosphorylation of ERK and PKC was induced by epinephrine, and ERK and PKC specific inhibitors concentration-dependently prevented epinephrine-induced phosphorylation of MAP-2c at ser136.
Negative_regulation (inhibitors) of ERK
18) Confidence 0.43 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.25
The ERK activation was blocked by preincubation with atropine or an M3 muscarinic acetylcholine receptor antagonist 4-diphenyacetooxy-1, 1-dimethylpiperidinium, indicating that is was mediated by M3 muscarinic acetylcholine receptor activation.
Negative_regulation (blocked) of ERK
19) Confidence 0.42 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
ERK inhibition by intrathecal PD 98059 had no effect on bladder reflex contractions of non-inflamed bladders but significantly decreased its frequency in inflamed animals.
Negative_regulation (inhibition) of ERK in bladder associated with intrathecal
20) Confidence 0.42 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15733095 Disease Relevance 0.31 Pain Relevance 0.37

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