INT48922

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 5.73
Pain Relevance 6.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
visceral 2
neurons 2
spinal cord 2
nucleus 2
dorsal horn 2
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 30 99.84 Very High Very High Very High
Spinal cord 85 99.82 Very High Very High Very High
qutenza 227 99.78 Very High Very High Very High
amygdala 91 99.68 Very High Very High Very High
Dorsal horn neuron 53 99.52 Very High Very High Very High
Visceral pain 10 99.08 Very High Very High Very High
c fibre 33 98.92 Very High Very High Very High
Dorsal horn 61 98.84 Very High Very High Very High
nMDA receptor 54 97.80 Very High Very High Very High
Rostral ventromedial medulla 77 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 79 99.68 Very High Very High Very High
Injury 26 99.68 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

10 99.08 Very High Very High Very High
Diabetes Mellitus 132 98.96 Very High Very High Very High
Noma 2 98.40 Very High Very High Very High
Nociception 94 96.92 Very High Very High Very High
Brain Injury 8 96.84 Very High Very High Very High
Hyperalgesia 58 96.08 Very High Very High Very High
Pain 73 92.04 High High
Anxiety Disorder 41 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the regional differences in ERK and ERK kinase expression and the region-specific regulation of ERK expression suggest that ERK-related signaling may play an important role in CNS function and its adaptive responses.
Regulation (regulation) of Gene_expression (expression) of ERK
1) Confidence 0.50 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0 Pain Relevance 0.48
Although most of these phosphatases are cytosolic, some may be found in the nucleus where they are responsible for ERK sequestration [15, 59, 60, 86, 105, 106].


Regulation (responsible) of Gene_expression (sequestration) of ERK in nucleus
2) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0 Pain Relevance 0.07
Phosphorylation of ERK significantly increased but there were no significant effects on cortical expression of ERK, Jun and p-38.
Neg (no) Regulation (effects) of Gene_expression (expression) of ERK
3) Confidence 0.40 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16024175 Disease Relevance 0.68 Pain Relevance 0.12
Therefore, the changes we observed in ERK expression in the mPFC as a result of NAL administration could be mediated by the direct or indirect connections from the vlPAG to mPFC.
Regulation (result) of Gene_expression (expression) of ERK associated with narcan
4) Confidence 0.40 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.20 Pain Relevance 0.51
Immunohistochemical studies revealed expression of EphB1 receptors in neurons in the dorsal horn and of the ligand ephrinB2 on small nociceptive neurons (both at the level of the cell body and on terminals in the dorsal horn).
Regulation (revealed) of Gene_expression (expression) of EphB1 in dorsal horn associated with nociception and dorsal horn
5) Confidence 0.38 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.47 Pain Relevance 0.95
The present study was designed to investigate the expression and modulation of pERK in the rat dorsal horn neurons produced by repetitive electrical stimulation, and its involvement in the electrophysiological activity of dorsal horn neurons.
Spec (investigate) Regulation (modulation) of Spec (investigate) Gene_expression (expression) of pERK in neurons associated with dorsal horn neuron
6) Confidence 0.38 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1941723 Disease Relevance 0 Pain Relevance 0.54
When we counted the number of pERK expressing cells within the RVM day 8 post SNI surgery, there was no difference between the 2 sham operated groups and results were pooled together (Fig. 3B; 134 ± 7).There was a significant increase in pERK expression when animals had received saline SNI treatment, both compared to SSP-SAP SNI and sham animals (Fig. 3B; 174 ± 7 vs 127 ± 7, P < 0.001, and 174 ± 7 vs 134 ± 7, P < 0.01, saline SNI vs SSP-SAP SNI and saline SNI vs sham respectively).


Regulation (received) of Gene_expression (expression) of pERK associated with nervous system injury and rostral ventromedial medulla
7) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.08 Pain Relevance 0.21
The up-regulation in pERK and pCREB expressions could be blocked by pretreatment of PD98059.
Regulation (regulation) of Gene_expression (expressions) of pERK
8) Confidence 0.31 Published 2009 Journal Neurosci Bull Section Body Doc Link 19784086 Disease Relevance 0.07 Pain Relevance 0
The expression of ERK as determined by the levels of ERK-T appears to be unaffected by the injury although the high variations can be observed.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of ERK associated with injury
9) Confidence 0.25 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.10 Pain Relevance 0.04
Our results demonstrate that the level of consciousness may affect the expression of CRF and pERK in the CeA induced by visceral pain.
Spec (may) Regulation (affect) of Gene_expression (expression) of pERK in visceral associated with visceral pain and amygdala
10) Confidence 0.24 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.31 Pain Relevance 1.22
Thus, the increase of pERK expression was dependent with the frequency of the C-fiber electrical stimulation.
Regulation (dependent) of Gene_expression (expression) of pERK associated with c fibre
11) Confidence 0.23 Published 2007 Journal Mol Pain Section Body Doc Link PMC1941723 Disease Relevance 0 Pain Relevance 0.37
The rostro-caudal and dorso-ventral arrangement of pERK-LI cells in the Vc and C1-C2 was slightly expanded after capsaicin treatment, suggesting that the capsaicin treatment affects the somatotopic arrangement of pERK-LI cells expressed by thermal and mechanical stimuli of the face in Vc and C1-C2.
Regulation (affects) of in ventral Gene_expression (expressed) of pERK in face associated with qutenza
12) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2661045 Disease Relevance 0.29 Pain Relevance 0.68
This time-course change in pERK-LI cell expression in Vc was similar to that described by Noma et al. [30].
Regulation (change) of Gene_expression (expression) of pERK associated with noma
13) Confidence 0.19 Published 2008 Journal Mol Pain Section Body Doc Link PMC2661045 Disease Relevance 0.10 Pain Relevance 0.48
In the lumbar tract of the spinal cord, higher levels of activated PKCgamma, ERK 1,2, p38, SAP/JNK and c-Jun proteins were detected in the ipsilateral side in respect of sham.
Regulation (detected) of Gene_expression (levels) of ERK in spinal cord associated with spinal cord
14) Confidence 0.19 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.59 Pain Relevance 0.71
There was no change in the expression of total ERK 1 in 14-days and 28-days diabetes groups and ERK 2 in 28-days diabetes group as compared to control group (Fig 7A1–A3).
Neg (no) Regulation (change) of Gene_expression (expression) of ERK associated with diabetes mellitus
15) Confidence 0.09 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.25 Pain Relevance 0.10

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