INT48923

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Context Info
Confidence 0.77
First Reported 1995
Last Reported 2011
Negated 2
Speculated 16
Reported most in Body
Documents 211
Total Number 229
Disease Relevance 106.23
Pain Relevance 109.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 23
dorsal horn 10
spinal cord 9
skin 5
ACC 5
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Lasting pain 341 100.00 Very High Very High Very High
5HT 207 100.00 Very High Very High Very High
dorsal root ganglion 198 100.00 Very High Very High Very High
Serotonin 29 100.00 Very High Very High Very High
chemokine 7 100.00 Very High Very High Very High
qutenza 1810 99.98 Very High Very High Very High
Anterior cingulate cortex 534 99.98 Very High Very High Very High
intrathecal 271 99.98 Very High Very High Very High
Hyperalgesia 451 99.88 Very High Very High Very High
Spinal cord 771 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 1161 100.00 Very High Very High Very High
Nociception 721 100.00 Very High Very High Very High
Ganglion Cysts 330 100.00 Very High Very High Very High
Stress 132 100.00 Very High Very High Very High
Middle Cerebral Artery Infarction 7 99.96 Very High Very High Very High
Nervous System Injury 1031 99.88 Very High Very High Very High
Hyperalgesia 584 99.88 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

256 99.88 Very High Very High Very High
Neuropathic Pain 849 99.76 Very High Very High Very High
Neuroleptic Malignant Syndrome 69 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate whether the phosphorylation of extracellular signal-regulated kinase (ERK) is involved in autoimmune injury of the peripheral nervous system (PNS), the expression of phosphorylated ERK (p-ERK) was analyzed in experimental autoimmune neuritis (EAN) in rats.
Spec (analyzed) Gene_expression (expression) of ERK in peripheral nervous system associated with peripheral nervous system, experimental autoimmune neuritis, injury and neuritis
1) Confidence 0.77 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15531088 Disease Relevance 0.64 Pain Relevance 0.53
Immunohistochemistry showed that p-ERK protein was weakly expressed in Schwann cells and vascular endothelial cells in the sciatic nerves of CFA-immunized control rats.
Gene_expression (expressed) of ERK in Schwann cells associated with sciatic nerve
2) Confidence 0.77 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15531088 Disease Relevance 0.96 Pain Relevance 0.78
ERK 1 and 2 share an 83% homology in their sequences and are expressed in all tissues [15, 90].
Gene_expression (expressed) of ERK
3) Confidence 0.76 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0 Pain Relevance 0
In the nervous system, the first descriptions of ERK expression and activation date from the early 1990’s and relate to the role of ERK in proliferation and differentiation of PC12 cells, derived from the rat adrenal phaechromocytoma [41].
Gene_expression (expression) of ERK in nervous system
4) Confidence 0.76 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0 Pain Relevance 0.12
Thus, the P-Erk expression pattern in the region is different from that of immediate early genes, such as c-Fos, which is widely expressed in ACC neurons located in all layers after formalin injection as previously reported [18].
Gene_expression (expression) of Erk in ACC neurons associated with anterior cingulate cortex
5) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.47 Pain Relevance 0.46
The expression of P-Erk was mainly restricted in the cell bodies but weak in their dendrites (Fig. 1A).
Gene_expression (expression) of Erk in dendrites
6) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.57 Pain Relevance 0.47
We found that formalin injection induced a rapid increase in P-Erk expression in some of layer II neurons in the bilateral ACC at 15 min after tissue injury (Fig. 1A).
Gene_expression (expression) of Erk in neurons associated with injury and anterior cingulate cortex
7) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.69 Pain Relevance 0.61
As shown in Fig. 1B, we found that larger number of the layer II pyramidal-like neurons in the ACC expressed P-Erk immunoreactivity at two weeks after single digit amputation.
Gene_expression (expressed) of Erk in digit associated with amputation and anterior cingulate cortex
8) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 1.27 Pain Relevance 1.03
The expression of p-Erk in the cytoplasm near the nucleus during the induction of chronic pain may play roles in the activation of a series of plasticity-related immediate early genes such as cAMP response element binding protein (CREB) [16].
Gene_expression (expression) of Erk in nucleus associated with lasting pain
9) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 1.30 Pain Relevance 1.11
Interestingly, the P-Erk expression in these neurons was present in cytoplasm of both cell body and dendrites (Fig. 1B).
Gene_expression (expression) of Erk in cell body
10) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 1.42 Pain Relevance 1.11
The activated ERK was also expressed in the intermediolateral nucleus (IML), nucleus intercalatus (IC) and the long processes projecting to the central canal, regions closely associated with autonomic outflow.
Gene_expression (expressed) of ERK in outflow associated with urological neuroanatomy
11) Confidence 0.73 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15265585 Disease Relevance 0.84 Pain Relevance 0.22
The upregulated phospho-ERK was evidently expressed in the superficial and deep dorsal horn of the thoracic spinal cord.
Gene_expression (expressed) of ERK in dorsal horn associated with dorsal horn and spinal cord
12) Confidence 0.73 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15265585 Disease Relevance 0.84 Pain Relevance 0.22
ERK and Akt are activated by phosphorylation, hence the levels of phosphorylated ERK (pERK) and Akt (pAkt) as well as total levels of ERK and Akt protein were measured by Western blot analysis.
Gene_expression (levels) of ERK
13) Confidence 0.73 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.78
ERK and Akt are activated by phosphorylation, hence the levels of phosphorylated ERK (pERK) and Akt (pAkt) as well as total levels of ERK and Akt protein were measured by Western blot analysis.
Gene_expression (levels) of pERK
14) Confidence 0.73 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.71
Furthermore, from week 2 to month 1, ERK-P was almost exclusively expressed in the Bungner's bands of Schwann cells.
Gene_expression (expressed) of ERK in bands
15) Confidence 0.73 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.24 Pain Relevance 0.07
The expression of ERK as determined by the levels of ERK-T appears to be unaffected by the injury although the high variations can be observed.
Gene_expression (expression) of ERK associated with injury
16) Confidence 0.73 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.10 Pain Relevance 0.04
Interrupted anterograde axonal transport at the crush site resulting in the accumulation of ERK-P in the proximal nerve segment may account for the earlier increase in the expression of ERK-P in this part at post-crush day 1 than in the DRG (7 days).
Gene_expression (expression) of ERK in proximal
17) Confidence 0.73 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.24 Pain Relevance 0.05
Expression of ephrinB2 and EphB1 were examined by immunoblotting and immunohistochemical analyses with anti-EphB and anti-ephrinB antibodies.
Spec (examined) Gene_expression (Expression) of EphB1
18) Confidence 0.72 Published 2007 Journal Spine Section Body Doc Link 17621205 Disease Relevance 0.07 Pain Relevance 0
EphB1 was expressed in neurons of spinal cord.
Gene_expression (expressed) of EphB1 in neurons
19) Confidence 0.72 Published 2007 Journal Spine Section Body Doc Link 17621205 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Expression of ephrinB2 is enhanced by nerve injury in neurons in DRG and spinal cord, while its receptor EphB1 is expressed in spinal cord.
Gene_expression (expressed) of EphB1 in spinal cord
20) Confidence 0.72 Published 2007 Journal Spine Section Body Doc Link 17621205 Disease Relevance 0 Pain Relevance 0

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