INT48924

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 107
Total Number 109
Disease Relevance 50.53
Pain Relevance 34.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Anatomy Link Frequency
DRG 9
brain 5
neurons 5
PSCs 3
hippocampus 3
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 57 100.00 Very High Very High Very High
Morphine 28 100.00 Very High Very High Very High
Kinase C 8 100.00 Very High Very High Very High
Inflammation 316 99.98 Very High Very High Very High
agonist 41 99.90 Very High Very High Very High
Spinal cord 658 99.80 Very High Very High Very High
Eae 32 99.80 Very High Very High Very High
dorsal root ganglion 67 99.76 Very High Very High Very High
substance P 58 99.76 Very High Very High Very High
nociceptor 60 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 643 99.98 Very High Very High Very High
INFLAMMATION 321 99.98 Very High Very High Very High
Hepatitis C Virus Infection 22 99.98 Very High Very High Very High
Apoptosis 364 99.84 Very High Very High Very High
Chronic Hepatitis 93 99.84 Very High Very High Very High
Aging 6 99.84 Very High Very High Very High
Nociception 307 99.82 Very High Very High Very High
Inflammatory Pain 31 99.80 Very High Very High Very High
Diabetes Mellitus 43 99.68 Very High Very High Very High
Primary Sclerosing Cholangitis 95 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATP causes the activation of p38 or ERK1/2, mitogen activated protein kinases (MAPKs) resulting in the release of tumor necrosis factor-alpha (TNF) and Interleukin-6 (IL-6) from microglia.
Positive_regulation (activation) of ERK1 in microglia associated with necrosis and cancer
1) Confidence 0.67 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607246 Disease Relevance 0.42 Pain Relevance 0.07
Our data suggest that IL-1beta (10 ng/ml) causes an enhancement of U46619-mediated basilar artery contraction that probably involves TTX-sensitive neuronal release of an alpha1-adrenoceptor agonist and activation of p42/p44 and p38 mitogen-activated protein kinases/p21(ras) pathways.
Positive_regulation (activation) of p44 in neuronal associated with agonist
2) Confidence 0.67 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16438962 Disease Relevance 0.07 Pain Relevance 0.17
CONCLUSIONS: The perivascular distribution of t-ERK1/2 and p-ERK1/2 in nerve fibers in the PDL is compatible with a role for the constitutive activation of ERK1/2 in the neural regulation of blood vessels in the PDL.
Positive_regulation (activation) of ERK1 in PDL
3) Confidence 0.67 Published 2009 Journal J. Periodontol. Section Body Doc Link 19405839 Disease Relevance 0 Pain Relevance 0
In conclusion, this study demonstrates that NTS2 is a bona fide NT receptor and that activation of this receptor by NT or NT analogs results in an internalization-dependent activation of the ERK1/2 signaling cascade.
Positive_regulation (activation) of ERK1
4) Confidence 0.67 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.06
CONCLUSIONS: The activation of ERK1/2 pathways in DRG neurons by noxious GD may be correlated with functional activity, and may be involved in acute visceral pain.


Positive_regulation (activation) of ERK1 in DRG
5) Confidence 0.67 Published 2008 Journal Gastroenterology Section Body Doc Link 18395090 Disease Relevance 0.10 Pain Relevance 0
Splanchnic nerve resection, but not vagotomy, affected the visceromotor response, and attenuated the ERK1/2 activation in DRG neurons produced by GD.
Positive_regulation (activation) of ERK1 in DRG
6) Confidence 0.67 Published 2008 Journal Gastroenterology Section Body Doc Link 18395090 Disease Relevance 0.12 Pain Relevance 0
The agonist-induced activation of ERK1/2 was completely abolished by preincubation of the cells with the endocytosis inhibitors phenylarsine oxide and monodansylcadaverine as well as overexpression of a dominant-negative mutant of dynamin 1 (DynK44A), indicating that receptor internalization was required for ERK1/2 activation.
Positive_regulation (activation) of ERK1 associated with agonist
7) Confidence 0.67 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.25
All compounds tested produced a rapid and sustained activation of extracellular signal-regulated kinases 1/2 (ERK1/2) but were without specific effect on Ca(2+) mobilization.
Positive_regulation (activation) of ERK1
8) Confidence 0.67 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.26
Overexpression of ErbB2 in the exocrine pancreas resulted in increased RAS activity and downstream activation of ERK1/2, but not in transgenic increased proliferation of acinar and ductal cells.
Neg (not) Positive_regulation (activation) of ERK1 in exocrine pancreas associated with targeted disruption
9) Confidence 0.67 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.55 Pain Relevance 0.21
We recently reported that activation of extracellular signal-regulated kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinase cascade in primary afferent neurons, was induced by noxious gastric distention in the rat, and that the activation of ERK1/2 in dorsal root ganglion (DRG) neurons can be implicated in acute visceral pain.
Positive_regulation (activation) of ERK1 in DRG associated with ganglion cysts, dorsal root ganglion and visceral pain
10) Confidence 0.67 Published 2010 Journal Digestion Section Abstract Doc Link 20588026 Disease Relevance 0.61 Pain Relevance 0.43
Recently, it has been shown that intracerebroventricular (i.c.v.) injection of the D-1 DA receptor agonist, SKF-82958, produces an enhanced locomotor-activating effect as well as increased activation of striatal ERK 1/2 MAP kinase, CaM kinase II, CREB, and c-fos in food-restricted (FR) relative to ad libitum fed (AL) rats.
Positive_regulation (activation) of ERK 1 associated with dopamine, agonist and intracerebroventricular
11) Confidence 0.67 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.09 Pain Relevance 0.69
Intrathecal injection of TRPA1 antisense attenuated the visceromotor response, and suppressed ERK1/2 activation in the DRG, but not NG, neurons produced by GD.
Positive_regulation (activation) of ERK1 in DRG
12) Confidence 0.67 Published 2009 Journal Gut Section Body Doc Link 19515638 Disease Relevance 0.07 Pain Relevance 0
RESULTS: Ethanol and acetaldehyde increased the activation of all 3 subfamilies (ERK 1/2, JNK and p38 kinase) of the MAPK pathway in PSCs.
Positive_regulation (activation) of ERK 1 in PSCs
13) Confidence 0.67 Published 2003 Journal Pancreas Section Body Doc Link 12883264 Disease Relevance 0 Pain Relevance 0
It is known that activation of the MEK/ERK signal transduction pathway prevents apoptosis.
Positive_regulation (activation) of ERK associated with apoptosis
14) Confidence 0.67 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.17 Pain Relevance 0
JNK and p42/p44 activity was significantly increased in the diabetic heart, while IGF-1R phosphorylation, IRS-2 tyrosine phosphorylation, and Akt activities were reduced.
Positive_regulation (increased) of p44 in heart associated with diabetes mellitus
15) Confidence 0.67 Published 2010 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 20555424 Disease Relevance 1.10 Pain Relevance 0.20
The Na+ effect was concentration-dependent (maximal effect, </=12.5 mM) and was specific for shear stress-mediated ERK1/2 activation as epidermal growth factor-stimulated ERK1/2 activation was unaffected by removal of extracellular Na+.
Positive_regulation (activation) of ERK1 associated with stress
16) Confidence 0.67 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.67 Pain Relevance 0.35
The phosphorylated form threonine/tyrosine (Thr/Tyr)-phosphorylated ERK1/2 was strongly increased in CH and LDH.
Positive_regulation (increased) of ERK1 associated with chronic hepatitis
17) Confidence 0.67 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 2.13 Pain Relevance 0.04
The Na+ effect was concentration-dependent (maximal effect, </=12.5 mM) and was specific for shear stress-mediated ERK1/2 activation as epidermal growth factor-stimulated ERK1/2 activation was unaffected by removal of extracellular Na+.
Positive_regulation (activation) of ERK1 associated with stress
18) Confidence 0.67 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.67 Pain Relevance 0.33
Transfection of Chinese hamster ovary cells with a rat brain type IIa voltage-gated sodium channel completely inhibited shear stress-mediated ERK1/2 activation in these cells.
Positive_regulation (activation) of ERK1 in brain associated with stress and sodium channel
19) Confidence 0.67 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.61 Pain Relevance 0.48
Additionally, s.c. injection of either saline or bee venom significantly augmented the activation of ERK1 and ERK2 (Fig. 3A, Tables 1 and 2).
Positive_regulation (activation) of ERK1
20) Confidence 0.62 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.28 Pain Relevance 0.38

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