INT48925

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Context Info
Confidence 0.74
First Reported 1995
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 95
Total Number 102
Disease Relevance 42.21
Pain Relevance 32.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
spinal cord 9
thoracic aorta 9
hippocampus 8
medulla 7
kidney cortex 6
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 571 100.00 Very High Very High Very High
agonist 182 100.00 Very High Very High Very High
Ventral tegmentum 14 100.00 Very High Very High Very High
COX2 2 99.88 Very High Very High Very High
Rostral ventrolateral medulla 275 99.84 Very High Very High Very High
medulla 557 99.72 Very High Very High Very High
Spinal cord 1000 99.70 Very High Very High Very High
Hippocampus 833 99.68 Very High Very High Very High
Pain 1698 99.56 Very High Very High Very High
withdrawal 88 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 273 99.96 Very High Very High Very High
Diabetes Mellitus 2772 99.84 Very High Very High Very High
Pain 2303 99.56 Very High Very High Very High
Death 314 99.52 Very High Very High Very High
Urological Neuroanatomy 55 99.34 Very High Very High Very High
Depression 140 99.32 Very High Very High Very High
Cancer 274 98.76 Very High Very High Very High
Poisoning 39 98.72 Very High Very High Very High
Necrosis 5 98.52 Very High Very High Very High
Herpes Simplex Virus 2 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using herpes simplex virus-mediated gene transfer to assess the functional significance of this ERK induction, we show that overexpressing ERK2 within the VTA increases susceptibility to stress as measured in the forced swim test, responses to unconditioned nociceptive stimuli, and elevated plus maze in Sprague Dawley male rats, and in the tail suspension test and chronic social defeat stress procedure in C57BL/6 male mice.
Gene_expression (overexpressing) of ERK2 in tail associated with nociception, stress, ventral tegmentum, herpes simplex virus and eae
1) Confidence 0.74 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519540 Disease Relevance 0.84 Pain Relevance 0.32
protein levels as well as on the total ERK1/2 expression and activation.
Gene_expression (expression) of ERK1/2
2) Confidence 0.74 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
In an attempt to unmask the state-dependent changes in the phosphorylation and total expression of ERK1 and ERK2 and hence illustrate the potential influences of pain-related behavioral consequence on ERK-mediated intracellular signaling pathways, we tested the temporal alterations in both pERK1/2 and tERK1/2 after s.c. saline or bee venom injection.
Gene_expression (expression) of ERK2 associated with pain
3) Confidence 0.74 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.36 Pain Relevance 0.40
With respect to the activated fraction of ERKs, pERK1 was rarely seen in SI area of naïve rats (Fig. 2A), however, pERK2 was normally expressed with a high level in this area at all time points we examined, although little differences occurred in the exact amounts of pERK2 among some time points.
Gene_expression (expressed) of pERK2
4) Confidence 0.74 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.30 Pain Relevance 0.40
Therefore, the aim of the present series of experiments is to assess the spatial- and temporal-related changes in phosphorylation (activation) and protein expression of ERKs, mainly ERK1 and ERK2, in the spinal cord dorsal horn, SI area and hippocampus under both physiological pain (transient pain) and pathological pain (persistent pain) states.
Gene_expression (expression) of ERK2 in spinal cord dorsal horn associated with pain, lasting pain, dorsal horn, painful pain, hippocampus and spinal cord
5) Confidence 0.74 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 1.61 Pain Relevance 1.54
By contrast, in subfractions containing purified nuclei, levels of ERK1 and ERK2 were about one-third of those seen in homogenates and, in subfractions enriched in mitochondria, both ERK1 and ERK2 were barely detectable.
Gene_expression (detectable) of ERK2
6) Confidence 0.73 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0.16 Pain Relevance 0.32
By contrast, in subfractions containing purified nuclei, levels of ERK1 and ERK2 were about one-third of those seen in homogenates and, in subfractions enriched in mitochondria, both ERK1 and ERK2 were barely detectable.
Gene_expression (levels) of ERK2
7) Confidence 0.73 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0.17 Pain Relevance 0.24
In contrast, blocking ERK2 activity in the VTA produces stress-resistant behavioral responses in these same assays and also blocks a chronic stress-induced reduction in sucrose preference.
Gene_expression (produces) of ERK2 associated with stress and ventral tegmentum
8) Confidence 0.64 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519540 Disease Relevance 0.84 Pain Relevance 0.37
Extracellular signal-regulated kinases such as ERK1 [p44 mitogen-activated protein kinase (MAPK)] and ERK2 (p42 MAPK) are activated in the CNS under physiological and pathological conditions such as ischemia and epilepsy.
Gene_expression (such) of ERK2 associated with epilepsy and ischemia
9) Confidence 0.64 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15086522 Disease Relevance 0.19 Pain Relevance 0.05
To investigate the functional roles of Gi2 on ERK1/2 activation, we examined the phosphorylation of ERK1/2 in ribozyme-treated cells following PGF2?
Spec (investigate) Gene_expression (activation) of ERK1/2
10) Confidence 0.64 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
Since cyclic AMP was found to exert a negative control of ERK1/2 activation in hepatocytes [35], it can be speculated that the decreases in ERK1/2 responses observed subsequent to inhibition of Gi function might be caused by an elevation of intracellular levels of cyclic AMP.
Gene_expression (activation) of ERK1/2 in hepatocytes
11) Confidence 0.64 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.14 Pain Relevance 0
It also seemed that pERK2 level in the normal hippocampus was a bit higher than that in normal SI area of cortex (Fig. 2A and Fig. 3A).
Gene_expression (level) of pERK2 in hippocampus associated with hippocampus
12) Confidence 0.64 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.18 Pain Relevance 0.27
As shown in Fig. 2A, dramatic differences were observed in the immunoreactivity of tERK1 and tERK2 in contralateral S1 area from naïve rats, with ERK2 expressed more prominently than ERK1.
Gene_expression (expressed) of ERK2
13) Confidence 0.64 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.26 Pain Relevance 0.43
In clear contrast, pain-induced elevation of pERK2 level was not so much evident as pERK1 when compared to its corresponding normal state, perhaps due to its high basal expression level in naïve rats (Fig. 2A, Table 2).
Gene_expression (expression) of pERK2 associated with pain
14) Confidence 0.64 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.30 Pain Relevance 0.33
Similarly, pERK2, but not pERK1, was normally detectable in the hippocampus from naive rats.
Gene_expression (detectable) of pERK2 in hippocampus associated with hippocampus
15) Confidence 0.64 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.19 Pain Relevance 0.27
We can see, from this histogram, that ERK1 was phosphorylated at almost every time point examined except for 6 h, 12 h, and 48 h, whereas ERK2 was activated at much less time points.
Gene_expression (activated) of ERK2
16) Confidence 0.64 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.24 Pain Relevance 0.24
In subcellular fractions prepared from sucrose homogenates of frontal cortex and pons/medulla, both ERK1 and ERK2 were enriched in the synaptosomal and cytosolic fractions, whereas ERK2 was also enriched in the microsomal fraction.
Gene_expression (enriched) of ERK2 in medulla associated with medulla and urological neuroanatomy
17) Confidence 0.63 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0.18 Pain Relevance 0.24
By contrast, in subfractions containing purified nuclei, levels of ERK1 and ERK2 were about one-third of those seen in homogenates and, in subfractions enriched in mitochondria, both ERK1 and ERK2 were barely detectable.
Gene_expression (detectable) of ERK2
18) Confidence 0.63 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0.17 Pain Relevance 0.33
The aggregate ERK concentrations (ERK1 and ERK2) were relatively high in each of the brain regions studied, ranging from approximately 0.35 ng/microgram protein in cerebellum to approximately 1.2 ng/microgram protein in nucleus accumbens.
Gene_expression (high) of ERK2 in cerebellum associated with nucleus accumbens
19) Confidence 0.63 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0.06 Pain Relevance 0.15
ERK1 and ERK2 levels were increased selectively in locus coeruleus and caudate/putamen after chronic morphine treatment, whereas ERK kinase immunoreactivity remained unchanged in all of the brain regions analyzed.
Gene_expression (levels) of ERK2 in putamen associated with locus ceruleus and morphine
20) Confidence 0.63 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0 Pain Relevance 0.53

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