INT48927

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Context Info
Confidence 0.60
First Reported 1995
Last Reported 2010
Negated 4
Speculated 4
Reported most in Body
Documents 25
Total Number 29
Disease Relevance 14.06
Pain Relevance 12.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Anatomy Link Frequency
hippocampus 3
spinal cord 1
brain 1
amygdala 1
central nervous system 1
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 8 100.00 Very High Very High Very High
Endep 4 99.98 Very High Very High Very High
substance P 18 99.76 Very High Very High Very High
Central nervous system 70 99.74 Very High Very High Very High
nMDA receptor 150 99.68 Very High Very High Very High
Spinal cord 262 99.66 Very High Very High Very High
Dorsal horn 62 99.40 Very High Very High Very High
Glutamate 5 99.28 Very High Very High Very High
Hyperalgesia 61 99.22 Very High Very High Very High
Hippocampus 271 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 297 99.80 Very High Very High Very High
Urological Neuroanatomy 12 99.80 Very High Very High Very High
Nociception 120 99.76 Very High Very High Very High
Chronic Hepatitis 31 99.24 Very High Very High Very High
Hyperalgesia 69 99.22 Very High Very High Very High
Pain 532 99.06 Very High Very High Very High
Apoptosis 49 98.32 Very High Very High Very High
Glioma 10 98.00 Very High Very High Very High
Ganglion Cysts 20 97.80 Very High Very High Very High
Hepatitis C Virus Infection 7 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amitriptyline regulated ERK1/2 phosphorylation and activity in CHO/KOR and C6 glioma cells endogenously expressing kappa-opioid receptors, and this effect was attenuated by the kappa-opioid antagonist nor-binaltorphimine.
Regulation (regulated) of ERK1 in CHO associated with antagonist, kappa opioid receptor, opioid, endep and glioma
1) Confidence 0.60 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19828880 Disease Relevance 0.19 Pain Relevance 1.23
The second cascade is the extracellular regulated kinase cascade (MEK/ERK).
Regulation (regulated) of ERK
2) Confidence 0.44 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.22 Pain Relevance 0.05
These results indicate that shear stress-mediated ERK1/2 activation is regulated by extracellular sodium and demonstrate that ion transport via Na+ channels modulates EC responses to shear stress.
Regulation (regulated) of ERK1 associated with stress
3) Confidence 0.44 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.53 Pain Relevance 0.43
The current study was designed to examine the roles of the protein kinase C (PKC), Rho kinase, and p44/42 mitogen-activated protein kinase (p44/42 MAPK) signaling pathways in calcium (Ca2+)-sensitization mechanisms in ropivacaine-induced vascular contraction.
Spec (examine) Regulation (roles) of p44 associated with kinase c
4) Confidence 0.44 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16129980 Disease Relevance 0.10 Pain Relevance 0.15
The current study was designed to examine the roles of the protein kinase C (PKC), Rho kinase, and p44/42 mitogen-activated protein kinase (p44/42 MAPK) signaling pathways in calcium (Ca2+)-sensitization mechanisms in ropivacaine-induced vascular contraction.
Spec (examine) Regulation (roles) of p44 associated with kinase c
5) Confidence 0.44 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16129980 Disease Relevance 0.10 Pain Relevance 0.15
Thus, mechanical hyperalgesia triggered by ET-1 in the rat hind paw depends importantly on signaling pathways involving PLC, PKC, p38 MAPK, ERK1/2, and JNK, whereas the contribution of PLA2 is relatively minor.
Regulation (depends) of ERK1 in paw associated with hyperalgesia
6) Confidence 0.44 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16741065 Disease Relevance 0.52 Pain Relevance 0.51
Therefore, the aim of the present series of experiments is to assess the spatial- and temporal-related changes in phosphorylation (activation) and protein expression of ERKs, mainly ERK1 and ERK2, in the spinal cord dorsal horn, SI area and hippocampus under both physiological pain (transient pain) and pathological pain (persistent pain) states.
Regulation (changes) of ERK1 in spinal cord dorsal horn associated with pain, lasting pain, dorsal horn, painful pain, hippocampus and spinal cord
7) Confidence 0.40 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 1.64 Pain Relevance 1.61
Moreover, whereas Liu et al. [38] did not find any significant change in P-Erk levels, our studies indicated region-specific alterations in this kinase: increases in cortical areas (prefrontal and neocortical) and striatum, but not in the hippocampus or amygdala (Figs. 1 and 2).
Regulation (change) of P-Erk in amygdala associated with hippocampus and amygdala
8) Confidence 0.29 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.29 Pain Relevance 0.13
However, P-Erk and P-p38MAPK levels were unchanged in both restrained and swim stressed mice.
Neg (unchanged) Regulation (unchanged) of P-Erk
9) Confidence 0.29 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.70 Pain Relevance 0.08
Taken together, these results suggest that the thyroid status could modulate the integrity of neuronal cytoskeleton acting on the endogenous NF-associated phosphorylating system and that such effect could be related to glutamate-induced excitotoxicity, as well as ERK1/2 and JNK modulation.
Regulation (modulation) of ERK1 in thyroid associated with glutamate
10) Confidence 0.26 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.15 Pain Relevance 0.28
We investigated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinase cascade, in dorsal root ganglion (DRG) and nodose ganglion (NG) neurons by noxious gastric distention (GD) and its involvement in acute visceral pain in rats.
Regulation (regulated) of ERK1 in ganglion associated with ganglion cysts, dorsal root ganglion and visceral pain
11) Confidence 0.26 Published 2008 Journal Gastroenterology Section Abstract Doc Link 18395090 Disease Relevance 0.29 Pain Relevance 0.36
PP2A is one of the most important protein phosphatases in the central nervous system, and it can regulate the activities of many kinases both in vivo and in vitro, such as ERK/MAPKs, PKA, PKC, IKB kinase, and Ca/calmodulin-dependent kinase [35-37].
Regulation (regulate) of ERK in central nervous system associated with central nervous system
12) Confidence 0.26 Published 2006 Journal Mol Pain Section Body Doc Link PMC1456949 Disease Relevance 0.09 Pain Relevance 0.66
Precisely how NMDA receptors differentially regulate the activity of CREB or signaling molecules such as the extracellular signal-regulated kinases 1 and 2 (ERK1/2) is unknown, but differences in the NMDA receptor subunit composition and/or differences in signaling complexes associated with synaptic versus extrasynaptic NMDA receptors may be important [5,10-13].
Regulation (regulate) of ERK1 associated with nmda receptor
13) Confidence 0.26 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2267199 Disease Relevance 0.17 Pain Relevance 0.48
In the canine samples, an up regulation of the levels of phosphorylated ERK1/2 was observed in CH and LDH.
Regulation (regulation) of ERK1 associated with chronic hepatitis
14) Confidence 0.26 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.68 Pain Relevance 0.06
Quantitative blot immunolabeling techniques were used to determine the concentrations of ERK1 (M(r) 44 kDa) and ERK2 (M(r) 42 kDa), the two major extracellular signal-regulated protein kinases, in different regions of rat brain.
Regulation (concentrations) of ERK1 in brain
15) Confidence 0.25 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0 Pain Relevance 0.11
Combined differential participation of the spinal cord, SI area, and hippocampus in the multidimensional aspects of pain experience with region- and isoform-dependent responses of pERK1 and pERK2 to peripheral noxious stimulation observed in the present study, we propose a hypothesis that this differential activation of ERK1 and ERK2 across distinct regions under pain state might suggest the possibility for a different function of specific ERK members in the nociceptive processing and further provide a molecular basis for the differential involvement of individual components of nociceptive system in the diverse features of pain.
Spec (might) Regulation (responses) of pERK1 in hippocampus associated with nociception, pain, hippocampus and spinal cord
16) Confidence 0.24 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 1.00 Pain Relevance 1.01
We suggest, to some extent, that it maybe due to the differential activation and regulation of upstream activators for ERK1 and ERK2 (MEK1 or MEK2, for example) in different areas under the pain states.
Regulation (regulation) of ERK1 associated with pain
17) Confidence 0.24 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.47 Pain Relevance 0.75
There were no significant changes in total expression levels of ERK1 or ERK2 in ipsilateral hippocampus at any time point examined (data not shown).
Neg (no) Spec (examined) Regulation (changes) of ERK1 in hippocampus associated with hippocampus
18) Confidence 0.24 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.29 Pain Relevance 0.47
Interestingly, the relative differences between ERK1 and ERK2 immunoreactivity were quite the same as that previous study (see the present results).
Regulation (immunoreactivity) of ERK1
19) Confidence 0.24 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.09 Pain Relevance 0.36
Indeed, Erk1/2 activity is believed to be exclusively regulated by MEK1/2 [15].
Regulation (regulated) of Erk1
20) Confidence 0.22 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.17 Pain Relevance 0.12

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