INT48928

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1995
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 9.38
Pain Relevance 6.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
tail 4
spinal cord 2
IB4 2
dorsal horn 2
thoracic aorta 2
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 341 100.00 Very High Very High Very High
Ventral tegmentum 14 100.00 Very High Very High Very High
medulla 60 99.72 Very High Very High Very High
Spinal cord 105 99.64 Very High Very High Very High
Locus ceruleus 1 99.36 Very High Very High Very High
Dorsal horn 24 99.16 Very High Very High Very High
Morphine 3 99.16 Very High Very High Very High
spinal dorsal horn 2 98.56 Very High Very High Very High
Eae 2 98.20 Very High Very High Very High
Hippocampus 105 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 25 99.24 Very High Very High Very High
Diabetes Mellitus 264 99.04 Very High Very High Very High
Hypersensitivity 12 98.26 Very High Very High Very High
Herpes Simplex Virus 2 98.04 Very High Very High Very High
Nociception 110 97.96 Very High Very High Very High
Erythema 1 97.90 Very High Very High Very High
Pressure And Volume Under Development 1 97.70 Very High Very High Very High
Cv Unclassified Under Development 1 97.28 Very High Very High Very High
Epilepsy 1 96.76 Very High Very High Very High
Pain 289 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using herpes simplex virus-mediated gene transfer to assess the functional significance of this ERK induction, we show that overexpressing ERK2 within the VTA increases susceptibility to stress as measured in the forced swim test, responses to unconditioned nociceptive stimuli, and elevated plus maze in Sprague Dawley male rats, and in the tail suspension test and chronic social defeat stress procedure in C57BL/6 male mice.
Positive_regulation (increases) of Gene_expression (overexpressing) of ERK2 in tail associated with nociception, stress, ventral tegmentum, herpes simplex virus and eae
1) Confidence 0.48 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519540 Disease Relevance 0.85 Pain Relevance 0.32
Using herpes simplex virus-mediated gene transfer to assess the functional significance of this ERK induction, we show that overexpressing ERK2 within the VTA increases susceptibility to stress as measured in the forced swim test, responses to unconditioned nociceptive stimuli, and elevated plus maze in Sprague Dawley male rats, and in the tail suspension test and chronic social defeat stress procedure in C57BL/6 male mice.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ERK2 in tail associated with nociception, stress, ventral tegmentum, herpes simplex virus and eae
2) Confidence 0.48 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519540 Disease Relevance 0.84 Pain Relevance 0.32
Extracellular signal-regulated kinases such as ERK1 [p44 mitogen-activated protein kinase (MAPK)] and ERK2 (p42 MAPK) are activated in the CNS under physiological and pathological conditions such as ischemia and epilepsy.
Positive_regulation (activated) of Gene_expression (such) of ERK2 associated with epilepsy and ischemia
3) Confidence 0.48 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15086522 Disease Relevance 0.19 Pain Relevance 0.05
protein levels as well as on the total ERK1/2 expression and activation.
Positive_regulation (activation) of Gene_expression (expression) of ERK1/2
4) Confidence 0.48 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
Therefore, the aim of the present series of experiments is to assess the spatial- and temporal-related changes in phosphorylation (activation) and protein expression of ERKs, mainly ERK1 and ERK2, in the spinal cord dorsal horn, SI area and hippocampus under both physiological pain (transient pain) and pathological pain (persistent pain) states.
Positive_regulation (activation) of Gene_expression (expression) of ERK2 in spinal cord dorsal horn associated with pain, lasting pain, dorsal horn, painful pain, hippocampus and spinal cord
5) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 1.63 Pain Relevance 1.60
As shown in Fig. 2A, dramatic differences were observed in the immunoreactivity of tERK1 and tERK2 in contralateral S1 area from naïve rats, with ERK2 expressed more prominently than ERK1.
Positive_regulation (prominently) of Gene_expression (expressed) of ERK2
6) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.31 Pain Relevance 0.48
ERK1 and ERK2 levels were increased selectively in locus coeruleus and caudate/putamen after chronic morphine treatment, whereas ERK kinase immunoreactivity remained unchanged in all of the brain regions analyzed.
Positive_regulation (increased) of Gene_expression (levels) of ERK2 in putamen associated with locus ceruleus and morphine
7) Confidence 0.47 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0 Pain Relevance 0.53
We found that CFA injection caused an area of localized swelling, erythema, hypersensitivity to thermal stimuli, the decreased response time of hind paw licking (HPL), as well as upregulation of c-Fos protein expression and ERK2 phosphorylation in the ipsilateral spinal dorsal horn and the contralateral primary somatosensory area of cortex and the amygdala of rats.
Positive_regulation (upregulation) of Gene_expression (expression) of ERK2 in dorsal horn associated with pressure and volume under development, erythema, spinal dorsal horn, hypersensitivity and amygdala
8) Confidence 0.47 Published 2010 Journal Anat Rec (Hoboken) Section Abstract Doc Link 20583264 Disease Relevance 0.77 Pain Relevance 1.25
However, s.c. administration of bee venom into the plantar surface of one hindpaw, which could produce a prolonged tonic, monophasic nociceptive response characterized by continuously flinching or lifting the injected paw for 1–2 h [37,38], significantly elevated the phosphorylation level of both ERK1 and ERK2 in the ipsilateral spinal cord (Fig. 1A, Tables 1 and 2).
Positive_regulation (elevated) of Gene_expression (level) of ERK2 in spinal cord associated with nociception and spinal cord
9) Confidence 0.44 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.41 Pain Relevance 0.59
Activation of MEK1/2 or ERK1/2 underlies the augmentation of NOS I or PKG in RVLM during the pro-life phase
Positive_regulation (Activation) of Gene_expression (/) of ERK1/2 associated with rostral ventrolateral medulla
10) Confidence 0.40 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.46 Pain Relevance 0.22
Carbachol-induced tyrosine-phosphorylated proteins of 44 and 42 kd were determined by Western blot analysis and identified as activated ERK1 and ERK2 using anti-ERK antibody.
Positive_regulation (activated) of Gene_expression (using) of ERK2
11) Confidence 0.36 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
Dopamine and NMDA stimulation converge on ERK2 but not p38 nor JNK
Neg (nor) Positive_regulation (on) of Gene_expression (Dopamine) of ERK2 associated with dopamine
12) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.28
Application of 100 µM dopamine resulted in a faster and more sustained activation of ERK2, which approached its peak within 5 min (1.25±0.02, p<0.05, n?
Positive_regulation (activation) of Gene_expression (approached) of ERK2 associated with dopamine
13) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.16
Dopamine and NMDA stimulation converge on ERK2 but not p38 nor JNK
Neg (not) Positive_regulation (not) of Gene_expression (Dopamine) of ERK2 associated with dopamine
14) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.28
Expression of phosphorylated p38-MAPK was significantly increased in kidney cortex obtained from 28-days diabetes group as compared to 14-days diabetes and control groups.
Positive_regulation (increased) of Gene_expression (Expression) of p38-MAPK in kidney cortex associated with diabetes mellitus
15) Confidence 0.25 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.21 Pain Relevance 0.16
Total p38-MAPK and phosphorylated p38-MAPK protein expressions in thoracic aorta were significantly elevated in 14-days and 28-days diabetes groups as compared to control group (Fig 6A1–A3).
Positive_regulation (elevated) of Gene_expression (expressions) of p38-MAPK in thoracic aorta associated with diabetes mellitus
16) Confidence 0.17 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.26 Pain Relevance 0.16
The presence of 5 mM GLA caused a significant decrease in both ERK1 (27 ± 7.7%) and ERK2 (31 ± 8.7%) protein expression (Figure 2C, 2E) and mRNA expression (data not shown).
Positive_regulation (caused) of Gene_expression (expression) of ERK2
17) Confidence 0.12 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.48 Pain Relevance 0
The presence of 5 mM GLA caused a significant decrease in both ERK1 (27 ± 7.7%) and ERK2 (31 ± 8.7%) protein expression (Figure 2C, 2E) and mRNA expression (data not shown).
Positive_regulation (caused) of Gene_expression (expression) of ERK2
18) Confidence 0.12 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.47 Pain Relevance 0
But in contrast to NGF/GDNF, there is no EGF induced activation of Erk1/2 detectable in the heterogeneous system of DRG-neurons.
Neg (no) Positive_regulation (activation) of Gene_expression (detectable) of Erk1/2 in neurons
19) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.25 Pain Relevance 0
Interestingly, the increase in phosphorylated Erk1/2 is matched by an increase in total Erk1/2 expression.
Positive_regulation (increase) of Gene_expression (expression) of Erk1/2
20) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.05 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox