INT48929

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1995
Last Reported 2010
Negated 11
Speculated 13
Reported most in Abstract
Documents 71
Total Number 84
Disease Relevance 24.42
Pain Relevance 42.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 6
brain 3
spinal cord 3
dorsal horn 3
nucleus accumbens 3
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 134 100.00 Very High Very High Very High
Dorsal horn 134 100.00 Very High Very High Very High
Dorsal horn neuron 66 100.00 Very High Very High Very High
Kinase C 57 100.00 Very High Very High Very High
addiction 29 100.00 Very High Very High Very High
c fibre 26 100.00 Very High Very High Very High
nociceptor 18 100.00 Very High Very High Very High
fluoxetine 12 100.00 Very High Very High Very High
antidepressant 3 100.00 Very High Very High Very High
withdrawal 117 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 5 99.98 Very High Very High Very High
Pain 717 99.84 Very High Very High Very High
Pressure Volume 2 Under Development 8 99.80 Very High Very High Very High
Hyperalgesia 163 99.68 Very High Very High Very High
Hypoxia 4 99.64 Very High Very High Very High
Injury 123 99.52 Very High Very High Very High
Adult Respiratory Distress Syndrome 31 99.36 Very High Very High Very High
Stress 163 99.04 Very High Very High Very High
Depression 59 98.88 Very High Very High Very High
Cv Unclassified Under Development 25 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses.
Regulation (regulated) of ERK
1) Confidence 0.62 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.39 Pain Relevance 0.32
Regulation of ERK (extracellular signal regulated kinase), part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine.
Regulation (Regulation) of ERK associated with dopamine, cocaine and morphine
2) Confidence 0.60 Published 1996 Journal J. Neurosci. Section Title Doc Link 8764658 Disease Relevance 0 Pain Relevance 0.80
Chronic infusions of BDNF into the VTA reduced total ERK immunoreactivity with no change in ERK activity, and also blocked the morphine-induced increase in ERK activity.
Neg (no) Regulation (change) of ERK associated with ventral tegmentum and morphine
3) Confidence 0.60 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8764658 Disease Relevance 0.06 Pain Relevance 0.97
Activation of Erk in the anterior cingulate cortex during the induction and expression of chronic pain

The extracellular signal-regulated kinase (Erk) activity contributes to synaptic plasticity, a key mechanism for learning, memory and chronic pain.

Regulation (regulated) of Erk in cingulate cortex associated with lasting pain and anterior cingulate cortex
4) Confidence 0.60 Published 2008 Journal Mol Pain Section Title Doc Link PMC2503974 Disease Relevance 0.90 Pain Relevance 0.86
Therefore, we investigated the effects of chronic fluoxetine administration on extracellular signal-regulated kinase (ERK) 1 and 2, a group of MAPKs that mediate signal transduction from the cell surface downstream to the nucleus.
Spec (investigated) Regulation (regulated) of ERK in nucleus associated with fluoxetine
5) Confidence 0.57 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15935071 Disease Relevance 0.12 Pain Relevance 0.37
It is possible that the regulation of ERK activity in the amygdala by the vlPAG is achieved via this vlPAG-central nucleus connection.
Spec (possible) Regulation (regulation) of ERK in nucleus associated with amygdala
6) Confidence 0.54 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.23 Pain Relevance 0.39
ERK1 and ERK2 levels were increased selectively in locus coeruleus and caudate/putamen after chronic morphine treatment, whereas ERK kinase immunoreactivity remained unchanged in all of the brain regions analyzed.
Regulation (immunoreactivity) of ERK in putamen associated with locus ceruleus and morphine
7) Confidence 0.50 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0 Pain Relevance 0.52
Potential regulation of ERK and ERK kinase levels was also investigated in rats subjected to chronic morphine treatment.
Regulation (regulation) of ERK associated with morphine
8) Confidence 0.50 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0.05 Pain Relevance 0.55
Intra-VTA infusion of ERK1 antisense oligonucleotides mimicked the effects of chronic BDNF infusions on ERK immunoreactivity, ERK activity, and TH immunoreactivity in the VTA under both control and morphine-treated conditions.
Regulation (effects) of ERK associated with ventral tegmentum and morphine
9) Confidence 0.44 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8764658 Disease Relevance 0.10 Pain Relevance 1.29
Intra-VTA infusion of ERK1 antisense oligonucleotides mimicked the effects of chronic BDNF infusions on ERK immunoreactivity, ERK activity, and TH immunoreactivity in the VTA under both control and morphine-treated conditions.
Regulation (effects) of ERK associated with ventral tegmentum and morphine
10) Confidence 0.44 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8764658 Disease Relevance 0.10 Pain Relevance 1.30
Thus, the Erk activation in ACC neurons may play a role in Erk-dependent neuronal plasticity in the ACC during the induction or development of inflammatory pain.
Regulation (role) of Erk-dependent in neuronal associated with ipn and anterior cingulate cortex
11) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.86 Pain Relevance 0.75
Although tetracaine, lidocaine, and bupivacaine similarly suppressed carbachol-induced tyrosine phosphorylation and ERK activation, neither tetrodotoxin, veratridine, nor ouabain affected the carbachol-induced ERKs activation.
Neg (neither) Regulation (affected) of ERK
12) Confidence 0.44 Published 1999 Journal Anesthesiology Section Body Doc Link 10519505 Disease Relevance 0 Pain Relevance 0
We have shown that the signaling molecule ERK (extracellular signal-regulated kinase) is activated by C-fiber stimulation in dorsal horn neurons and contributes to pain sensitization.
Regulation (contributes) of ERK in neurons associated with pain, c fibre and dorsal horn neuron
13) Confidence 0.44 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16221738 Disease Relevance 0.51 Pain Relevance 1.93
The present study examined the regulation of ERK and Akt activation in the nucleus accumbens and caudate putamen following acute and chronic morphine administration in the rat.
Spec (examined) Regulation (regulation) of ERK in caudate putamen associated with nucleus accumbens and morphine
14) Confidence 0.43 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.52
This may suggest the down-regulation of ERK-P in Schwann cells in the proximal segment after injury.
Regulation (regulation) of ERK in proximal associated with injury
15) Confidence 0.42 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.29 Pain Relevance 0.13
Twenty-four and forty-eight hours after axotomy, the phosphorylation level of ERK 1/2 in the operation side of dorsal spinal cord was much higher than that in the contralateral side, while the total ERK 1/2 level seemed unchanged.
Neg (unchanged) Spec (seemed) Regulation (unchanged) of ERK in spinal cord associated with spinal cord
16) Confidence 0.38 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809691 Disease Relevance 0.29 Pain Relevance 0.52
In this study, we examined the involvement of spinal ERK and p38 MAPK in each phase of i.t.
Spec (examined) Regulation (involvement) of ERK in spinal
17) Confidence 0.38 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18520049 Disease Relevance 0.49 Pain Relevance 0.57
In the present study we provide more direct evidence supporting the hypothesis of a role of EphB receptors in physiological synaptic plasticity in vivo, via modulation of NMDA receptor activity, and in particular via Src-mediated phosphorylation of the NR2B subunit.
Regulation (role) of EphB associated with nmda receptor
18) Confidence 0.38 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.66 Pain Relevance 0.98
The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats.
Regulation (effect) of ERK associated with antidepressant, depression and fluoxetine
19) Confidence 0.37 Published 2008 Journal Neurobiol. Dis. Section Abstract Doc Link 18586506 Disease Relevance 0.59 Pain Relevance 0.55
Kevil et. al. showed ERK regulation of H2O2 induced occludin redistribution and permeability increases in endothelial cells [56].
Regulation (regulation) of ERK in endothelial cells
20) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox