INT4893

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Context Info
Confidence 0.78
First Reported 1980
Last Reported 2010
Negated 8
Speculated 7
Reported most in Abstract
Documents 366
Total Number 375
Disease Relevance 129.67
Pain Relevance 213.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
neurons 68
spinal cord 33
lamina 24
spinal 23
dorsal horn 17
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 4914 100.00 Very High Very High Very High
dorsal root ganglion 2822 100.00 Very High Very High Very High
Inflammation 1419 100.00 Very High Very High Very High
Pain 1136 100.00 Very High Very High Very High
Pyramidal cell 726 100.00 Very High Very High Very High
qutenza 675 100.00 Very High Very High Very High
spinothalamic 556 100.00 Very High Very High Very High
Kinase C 507 100.00 Very High Very High Very High
Neuropeptide 444 100.00 Very High Very High Very High
Nerve growth factor 399 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 3165 100.00 Very High Very High Very High
Nociception 1459 100.00 Very High Very High Very High
INFLAMMATION 1351 100.00 Very High Very High Very High
Depression 150 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 101 100.00 Very High Very High Very High
Respiratory Syncytial Virus 25 99.82 Very High Very High Very High
Death 20 99.70 Very High Very High Very High
Pain 1223 99.68 Very High Very High Very High
Inflammatory Pain 183 99.68 Very High Very High Very High
Stress 301 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a conjugate of substance P and the ribosome-inactivating protein saporin, neurons expressing the neurokinin-1 receptor in lamina I of the spinal cord were targeted to determine their role in the expression of a spontaneous pain behavior following intraspinal injections of quisqualic acid in the rat.
Gene_expression (expressing) of neurokinin-1 receptor in lamina associated with pain, spontaneous pain, spinal cord and substance p
1) Confidence 0.78 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135936 Disease Relevance 0.46 Pain Relevance 0.33
The results suggest that the substrate for at-level pain following spinal cord injury includes a population of spinal neurons expressing the neurokinin-1 receptor in the superficial laminae of the spinal cord.
Gene_expression (expressing) of neurokinin-1 receptor in spinal associated with pain and spinal cord
2) Confidence 0.78 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135936 Disease Relevance 0.68 Pain Relevance 0.51
The stimulation of NK-1R gene expression by activation of the NK-1R provides a homologous mechanism for altering the sensitivity of dorsal horn cells to substance P, potentially via the actions of second messengers, which presumably results in the maintenance of proper sensory information processing during long term nociception.
Gene_expression (expression) of NK-1R gene in dorsal horn associated with nociception, dorsal horn and substance p
3) Confidence 0.78 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.39 Pain Relevance 0.30
These results indicate that serotoninergic innervation of lamina I projection neurones in the rat spinal cord is related to expression of neurokinin 1 receptors, but not to morphology, and that (at least on heavily innervated neurones) most serotonin-containing boutons which are in contact form synapses.
Gene_expression (expression) of neurokinin 1 in synapses associated with serotonin and spinal cord
4) Confidence 0.78 Published 2002 Journal Neuroscience Section Abstract Doc Link 11927162 Disease Relevance 0 Pain Relevance 0.25
To test whether the strength of serotoninergic innervation of lamina I projection neurones was related to morphology or neurokinin 1 receptor expression, we used confocal microscopy to determine the density of serotoninergic contacts on 60 cells retrogradely labelled from the caudal ventrolateral medulla.
Gene_expression (expression) of neurokinin 1 in medulla associated with medulla
5) Confidence 0.78 Published 2002 Journal Neuroscience Section Abstract Doc Link 11927162 Disease Relevance 0.09 Pain Relevance 0.44
Destruction of neurons in the superficial dorsal horn that express substance P receptor (NK-1R) has been reported to block development of behavioral hypersensitivity following peripheral sensitization of nociceptors.
Gene_expression (express) of NK-1R in nociceptors associated with nociceptor, hypersensitivity, dorsal horn, peripheral sensitization and substance p
6) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 12763083 Disease Relevance 0.17 Pain Relevance 0.40
In the present study, we evaluated effects of intrathecal substance P-saporin (SP-sap), a toxin selective for cells expressing NK-1R, on operant escape responses of rats to thermal stimulation.
Gene_expression (expressing) of NK-1R associated with substance p and intrathecal
7) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 12763083 Disease Relevance 0.16 Pain Relevance 0.44
Spinal lamina I neurons that express neurokinin 1 receptors: morphological analysis.
Gene_expression (express) of neurokinin 1 in lamina
8) Confidence 0.78 Published 2000 Journal Neuroscience Section Title Doc Link 10799765 Disease Relevance 0 Pain Relevance 0.10
These observations are discussed in the light of other recent studies indicating a central role for lamina I neurons expressing neurokinin 1 in the perception of severe pain.
Gene_expression (expressing) of neurokinin 1 in neurons associated with pain
9) Confidence 0.78 Published 2000 Journal Neuroscience Section Abstract Doc Link 10799765 Disease Relevance 0.10 Pain Relevance 0.10
The morphology of neurons in lamina I of the dorsal horn of the lumbar spinal cord which express neurokinin 1 receptors in the rat has been investigated.
Gene_expression (express) of neurokinin 1 in lamina associated with dorsal horn and spinal cord
10) Confidence 0.78 Published 2000 Journal Neuroscience Section Abstract Doc Link 10799765 Disease Relevance 0 Pain Relevance 0.10
Although zymosan-induced colorectal inflammation alone did not induce SPR internalization in lamina I neurons, there was an increased number of SPR-expressing lamina I neurons showing SPR internalization in segments T12 through S2 of the spinal cord after colorectal distention.
Gene_expression (expressing) of SPR in spinal cord associated with inflammation and spinal cord
11) Confidence 0.78 Published 2002 Journal J Pain Section Abstract Doc Link 14622848 Disease Relevance 0.62 Pain Relevance 0.50
Spinal lamina I neurons expressing the substance P receptor (SPR) have been shown to play a role in the transmission of somatic inflammatory and neuropathic pain.
Gene_expression (expressing) of substance P receptor in Spinal associated with inflammation, neuropathic pain and substance p
12) Confidence 0.78 Published 2002 Journal J Pain Section Abstract Doc Link 14622848 Disease Relevance 0.50 Pain Relevance 0.42
Spinal lamina I neurons expressing the substance P receptor (SPR) have been shown to play a role in the transmission of somatic inflammatory and neuropathic pain.
Gene_expression (expressing) of SPR in Spinal associated with inflammation, neuropathic pain and substance p
13) Confidence 0.78 Published 2002 Journal J Pain Section Abstract Doc Link 14622848 Disease Relevance 0.50 Pain Relevance 0.42
NK-1R protein expression was examined by Western blotting.
Spec (examined) Gene_expression (expression) of NK-1R protein
14) Confidence 0.78 Published 2010 Journal Neurogastroenterol. Motil. Section Body Doc Link 20059697 Disease Relevance 0.08 Pain Relevance 0
NK-1R and tachykinin-1 mRNA were detected by real-time RT-PCR.
Gene_expression (detected) of NK-1R
15) Confidence 0.78 Published 2010 Journal Neurogastroenterol. Motil. Section Body Doc Link 20059697 Disease Relevance 0.08 Pain Relevance 0
Alterations in the excitability of these neurons influence chronic pain development, and expression of the neurokinin 1 receptor (NK-1r) is thought to play a major role in such changes.
Gene_expression (expression) of neurokinin 1 receptor in neurons associated with lasting pain
16) Confidence 0.78 Published 2009 Journal J. Comp. Neurol. Section Abstract Doc Link 19296480 Disease Relevance 0.27 Pain Relevance 0.36
Novel expression of NK-1r may underlie hyperexcitability in new populations of LI neurons.
Gene_expression (expression) of NK-1r in neurons associated with hyperexcitability
17) Confidence 0.78 Published 2009 Journal J. Comp. Neurol. Section Abstract Doc Link 19296480 Disease Relevance 0.31 Pain Relevance 0.36
De novo expression of the neurokinin 1 receptor in spinal lamina I pyramidal neurons in polyarthritis.
Gene_expression (expression) of neurokinin 1 receptor in spinal associated with pyramidal cell and arthritis
18) Confidence 0.78 Published 2009 Journal J. Comp. Neurol. Section Title Doc Link 19296480 Disease Relevance 0.34 Pain Relevance 0.41
In agreement with this, we have shown that spinoparabrachial pyramidal neurons seldom express NK-1r, in contrast with the other two cell types.
Gene_expression (express) of NK-1r in pyramidal neurons associated with pyramidal cell
19) Confidence 0.78 Published 2009 Journal J. Comp. Neurol. Section Abstract Doc Link 19296480 Disease Relevance 0.31 Pain Relevance 0.43
Alterations in the excitability of these neurons influence chronic pain development, and expression of the neurokinin 1 receptor (NK-1r) is thought to play a major role in such changes.
Gene_expression (expression) of NK-1r in neurons associated with lasting pain
20) Confidence 0.78 Published 2009 Journal J. Comp. Neurol. Section Abstract Doc Link 19296480 Disease Relevance 0.27 Pain Relevance 0.36

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