INT48933

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 2
Speculated 5
Reported most in Body
Documents 93
Total Number 98
Disease Relevance 44.39
Pain Relevance 37.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Anatomy Link Frequency
spinal cord 10
hippocampus 8
retina 2
brain 2
molar 2
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 2 100.00 Very High Very High Very High
Spinal cord 1144 99.96 Very High Very High Very High
analgesia 11 99.92 Very High Very High Very High
medulla 97 99.86 Very High Very High Very High
Snapping jaw 8 99.82 Very High Very High Very High
Ultiva 36 99.80 Very High Very High Very High
Hippocampus 842 99.78 Very High Very High Very High
transcutaneous nerve stimulation 7 99.72 Very High Very High Very High
Dorsal horn 336 99.60 Very High Very High Very High
spinal dorsal horn 54 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 8 99.82 Very High Very High Very High
Peripheral Arterial Disease 10 99.80 Very High Very High Very High
Myocardial Infarction 32 99.58 Very High Very High Very High
Hypersensitivity 165 99.54 Very High Very High Very High
Apoptosis 259 99.52 Very High Very High Very High
Urological Neuroanatomy 48 99.52 Very High Very High Very High
Pain 2392 99.34 Very High Very High Very High
Depression 57 99.32 Very High Very High Very High
Glioma 193 99.24 Very High Very High Very High
Inflammatory Pain 50 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remifentanil improved expression of ERK1/2 and anti-apoptotic protein Bcl2, and expression of sarcoplasmic reticulum genes which were significantly reduced in the I/R rats only.
Gene_expression (expression) of ERK1 in reticulum associated with ultiva and apoptosis
1) Confidence 0.75 Published 2010 Journal Physiol Res Section Abstract Doc Link 19681651 Disease Relevance 0.63 Pain Relevance 0.92
TRPA1 was coexpressed with ERK1/2 in gastric primary afferent neurons, and attenuation of TRPA1 activation using antisense peptides and a specific blocker led to suppression of both ERK1/2 activation and visceromotor responses.
Gene_expression (coexpressed) of ERK1 in afferent neurons
2) Confidence 0.75 Published 2010 Journal Digestion Section Abstract Doc Link 20588026 Disease Relevance 0.76 Pain Relevance 0.63
By contrast, in subfractions containing purified nuclei, levels of ERK1 and ERK2 were about one-third of those seen in homogenates and, in subfractions enriched in mitochondria, both ERK1 and ERK2 were barely detectable.
Gene_expression (detectable) of ERK1
3) Confidence 0.71 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0.16 Pain Relevance 0.32
By contrast, in subfractions containing purified nuclei, levels of ERK1 and ERK2 were about one-third of those seen in homogenates and, in subfractions enriched in mitochondria, both ERK1 and ERK2 were barely detectable.
Gene_expression (levels) of ERK1
4) Confidence 0.71 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0.17 Pain Relevance 0.24
In an attempt to unmask the state-dependent changes in the phosphorylation and total expression of ERK1 and ERK2 and hence illustrate the potential influences of pain-related behavioral consequence on ERK-mediated intracellular signaling pathways, we tested the temporal alterations in both pERK1/2 and tERK1/2 after s.c. saline or bee venom injection.
Gene_expression (expression) of ERK1 associated with pain
5) Confidence 0.69 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.35 Pain Relevance 0.40
Therefore, the aim of the present series of experiments is to assess the spatial- and temporal-related changes in phosphorylation (activation) and protein expression of ERKs, mainly ERK1 and ERK2, in the spinal cord dorsal horn, SI area and hippocampus under both physiological pain (transient pain) and pathological pain (persistent pain) states.
Gene_expression (expression) of ERK1 in spinal cord dorsal horn associated with pain, lasting pain, dorsal horn, painful pain, hippocampus and spinal cord
6) Confidence 0.69 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 1.61 Pain Relevance 1.54
Distinct PKC-activated MAPK pathways, including p38MAPK, ERK1/2 and JNK, were investigated in chronic oxaliplatin rat.
Gene_expression (/) of ERK1
7) Confidence 0.65 Published 2009 Journal Pain Section Abstract Doc Link 19683395 Disease Relevance 0.86 Pain Relevance 0.63
Other molecules are known to influence p38 MAPK function in an arthritic state, including map kinase family members (such as ERK1/2) and NF?
Gene_expression (/) of ERK1 associated with arthritis
8) Confidence 0.65 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 0.94 Pain Relevance 0.53
Western blot analysis on STAT3, PKB/Akt, ERK1/2, and p38MAPK in canine liver homogenates
Gene_expression (/) of ERK1 in liver
9) Confidence 0.65 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.44 Pain Relevance 0.03
(1:500), ERK1/2 and phospho-ERK1/2 (1:1000), MEK1/2 and phospho-MEK1/2 (1:1000), p38 MAPK and phospho-p38 MAPK (1:1000) (all from Cell Signalling Technology, Inc.
Gene_expression (/) of ERK1
10) Confidence 0.65 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2923122 Disease Relevance 0.07 Pain Relevance 0
(1:500), ERK1/2 and phospho-ERK1/2 (1:1000), MEK1/2 and phospho-MEK1/2 (1:1000), p38 MAPK and phospho-p38 MAPK (1:1000) (all from Cell Signalling Technology, Inc.
Gene_expression (/) of ERK1
11) Confidence 0.65 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2923122 Disease Relevance 0.07 Pain Relevance 0
Activation of protein kinases, including p38 MAPK, MEK1/2, and ERK1/2, has been implicated in neuronal death and survival following cerebral reperfusion [30] and has been associated with cPLA2?
Gene_expression (/) of ERK1 in neuronal associated with death
12) Confidence 0.65 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2923122 Disease Relevance 0.64 Pain Relevance 0.13
ERK1 and ERK2 levels were increased selectively in locus coeruleus and caudate/putamen after chronic morphine treatment, whereas ERK kinase immunoreactivity remained unchanged in all of the brain regions analyzed.
Gene_expression (levels) of ERK1 in putamen associated with locus ceruleus and morphine
13) Confidence 0.61 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0 Pain Relevance 0.53
In subcellular fractions prepared from sucrose homogenates of frontal cortex and pons/medulla, both ERK1 and ERK2 were enriched in the synaptosomal and cytosolic fractions, whereas ERK2 was also enriched in the microsomal fraction.
Gene_expression (enriched) of ERK1 in medulla associated with medulla and urological neuroanatomy
14) Confidence 0.61 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0.19 Pain Relevance 0.24
The aggregate ERK concentrations (ERK1 and ERK2) were relatively high in each of the brain regions studied, ranging from approximately 0.35 ng/microgram protein in cerebellum to approximately 1.2 ng/microgram protein in nucleus accumbens.
Gene_expression (high) of ERK1 in cerebellum associated with nucleus accumbens
15) Confidence 0.61 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0.06 Pain Relevance 0.15
By contrast, in subfractions containing purified nuclei, levels of ERK1 and ERK2 were about one-third of those seen in homogenates and, in subfractions enriched in mitochondria, both ERK1 and ERK2 were barely detectable.
Gene_expression (levels) of ERK1
16) Confidence 0.61 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0.17 Pain Relevance 0.24
Our immunoblotting results revealed that pERK1 was induced to express at a highly detectable level in contralateral SI area following both injection, when compared to the naïve control state (Fig. 2A, Table 1).
Gene_expression (express) of pERK1
17) Confidence 0.60 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.29 Pain Relevance 0.32
In clear contrast, pain-induced elevation of pERK2 level was not so much evident as pERK1 when compared to its corresponding normal state, perhaps due to its high basal expression level in naïve rats (Fig. 2A, Table 2).
Gene_expression (expression) of pERK1 associated with pain
18) Confidence 0.60 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.25 Pain Relevance 0.28
Similarly, pERK2, but not pERK1, was normally detectable in the hippocampus from naive rats.
Gene_expression (detectable) of pERK1 in hippocampus associated with hippocampus
19) Confidence 0.60 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.19 Pain Relevance 0.27
In order to examine the spatial and temporal patterns of ERK1/2 phosphorylation and expression, all three groups of rats were anesthetized with intraperitoneal injection of sodium pentobarbital (50 mg/kg, i.p.) and decapitated at various time points (5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, 24 h, 48 h) after the injection.
Gene_expression (expression) of ERK1
20) Confidence 0.60 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.30 Pain Relevance 0.37

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