INT48934

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 5
Speculated 12
Reported most in Body
Documents 157
Total Number 202
Disease Relevance 60.61
Pain Relevance 61.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
neurons 14
spinal cord 9
hepatocytes 7
brain stem 7
spinal 5
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 1488 100.00 Very High Very High Very High
Rostral ventrolateral medulla 715 100.00 Very High Very High Very High
nMDA receptor 715 100.00 Very High Very High Very High
addiction 44 100.00 Very High Very High Very High
Dopamine 4192 99.98 Very High Very High Very High
agonist 588 99.92 Very High Very High Very High
Spinal cord 1026 99.84 Very High Very High Very High
dopamine receptor 265 99.84 Very High Very High Very High
fluoxetine 16 99.78 Very High Very High Very High
Inflammation 611 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 448 99.98 Very High Very High Very High
Hypersensitivity 562 99.92 Very High Very High Very High
Premature Birth 1 99.86 Very High Very High Very High
Diabetes Mellitus 1452 99.84 Very High Very High Very High
Aging 3 99.76 Very High Very High Very High
INFLAMMATION 633 99.72 Very High Very High Very High
Morphine Dependence 2 99.68 Very High Very High Very High
Hyperalgesia 1297 99.56 Very High Very High Very High
Bordatella Infection 161 99.54 Very High Very High Very High
Dysmenorrhea 9 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, TENS application suppressed the CFA-induced ERK2 activation and c-Fos protein expression.
Positive_regulation (activation) of ERK2 associated with transcutaneous nerve stimulation
1) Confidence 0.70 Published 2010 Journal Anat Rec (Hoboken) Section Abstract Doc Link 20583264 Disease Relevance 0.64 Pain Relevance 1.21
Previous evidences suggest that the activation of the p38 MAPK signaling pathway in hyperactive microglia in the dorsal horn of spinal cord involves in nerve injury-induced neuropathic pain.
Positive_regulation (activation) of p38 MAPK in dorsal horn associated with nervous system injury, neuropathic pain, dorsal horn and spinal cord
2) Confidence 0.69 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18191894 Disease Relevance 0.68 Pain Relevance 1.23
Extracellular signal-regulated kinases such as ERK1 [p44 mitogen-activated protein kinase (MAPK)] and ERK2 (p42 MAPK) are activated in the CNS under physiological and pathological conditions such as ischemia and epilepsy.
Positive_regulation (activated) of ERK2 associated with epilepsy and ischemia
3) Confidence 0.66 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15086522 Disease Relevance 0.19 Pain Relevance 0.05
The data obtained with the ribozyme suggest that Gi2 is an important factor in ERK1/2 activation.
Positive_regulation (activation) of ERK1/2
4) Confidence 0.66 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
This suggests that the PTX effects that have been observed, at least on ERK1/2 activation in response to PGF2?
Positive_regulation (activation) of ERK1/2
5) Confidence 0.66 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.08 Pain Relevance 0
Gi proteins are believed to be involved in regulation of cell growth [20], and a role in activation of ERK1/2 is reported in different cells [21,22,23].
Positive_regulation (activation) of ERK1/2
6) Confidence 0.66 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
expression and ERK1/2 activation by ribozyme treatment
Positive_regulation (activation) of ERK1/2
7) Confidence 0.66 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
Furthermore, as shown in the present study ribozyme treatment of the hepatocytes did not decrease the basal ERK1/2 activation thus suggesting no significant alteration of cyclic AMP level under these experimental conditions.
Positive_regulation (activation) of ERK1/2 in hepatocytes
8) Confidence 0.66 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.09 Pain Relevance 0
However, the present data do not rule out a possible contribution of Gi3 in ERK1/2 activation.
Spec (possible) Positive_regulation (activation) of ERK1/2
9) Confidence 0.66 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.07 Pain Relevance 0
-induced ERK1/2 activation in hepatocytes.
Positive_regulation (activation) of ERK1/2 in hepatocytes
10) Confidence 0.66 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
In hepatocytes it has been observed that PTX inhibited activation of ERK1/2 both by agents acting on G protein coupled receptors including vasopressin, angiotensin II, norepinephrine and PGF2?
Positive_regulation (activation) of ERK1/2 in hepatocytes
11) Confidence 0.66 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.06 Pain Relevance 0
The present data show a close correlation between the inhibitory effect on ERK1/2 activation produced by the Gi2?
Positive_regulation (activation) of ERK1/2
12) Confidence 0.66 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.08 Pain Relevance 0
Combined differential participation of the spinal cord, SI area, and hippocampus in the multidimensional aspects of pain experience with region- and isoform-dependent responses of pERK1 and pERK2 to peripheral noxious stimulation observed in the present study, we propose a hypothesis that this differential activation of ERK1 and ERK2 across distinct regions under pain state might suggest the possibility for a different function of specific ERK members in the nociceptive processing and further provide a molecular basis for the differential involvement of individual components of nociceptive system in the diverse features of pain.
Positive_regulation (activation) of ERK2 in hippocampus associated with nociception, pain, hippocampus and spinal cord
13) Confidence 0.66 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 1.10 Pain Relevance 1.06
Additionally, s.c. injection of either saline or bee venom significantly augmented the activation of ERK1 and ERK2 (Fig. 3A, Tables 1 and 2).
Positive_regulation (activation) of ERK2
14) Confidence 0.66 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.28 Pain Relevance 0.39
Activation of MEK1/2 or ERK1/2 underlies the augmentation of NOS I or PKG in RVLM during the pro-life phase
Positive_regulation (Activation) of ERK1/2 associated with rostral ventrolateral medulla
15) Confidence 0.55 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.46 Pain Relevance 0.22
Activation of MEK1/2, ERK1/2 or MNK1/2 in RVLM sustains central cardiovascular regulation associated with experimental brain stem death
Positive_regulation (Activation) of ERK1/2 in brain stem associated with rostral ventrolateral medulla and death
16) Confidence 0.55 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.63 Pain Relevance 0.37
Based on the stipulation that the magnitude and duration of the LF component of SAP signals during experimental brain stem death reflect the prevalence of the life-and-death signal [4], we next employed pharmacological blockade to evaluate whether a causal relationship exists between activation of ERK1/2 in RVLM and central cardiovascular regulation during brain stem death.
Spec (whether) Positive_regulation (activation) of ERK1/2 in brain stem associated with rostral ventrolateral medulla and death
17) Confidence 0.55 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.66 Pain Relevance 0.37
We first evaluated the fundamental premise that ERK1/2 in RVLM is activated during experimental brain stem death.
Positive_regulation (activated) of ERK1/2 in brain stem associated with rostral ventrolateral medulla and death
18) Confidence 0.55 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.59 Pain Relevance 0.32
With particular relevance to this study, ERK1/2 activation leads to NOS I induction in rat PC12 cells [18] and in rat aortic smooth muscle cells [19].
Positive_regulation (activation) of ERK1/2 in smooth muscle cells
19) Confidence 0.55 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.66 Pain Relevance 0.13
Pharmacological blockade was again used to ascertain that these temporally correlated biochemical changes are causally linked to MEK1/2 or ERK1/2 activation in RVLM during experimental brain stem death.
Positive_regulation (activation) of ERK1/2 in brain stem associated with rostral ventrolateral medulla and death
20) Confidence 0.55 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.60 Pain Relevance 0.32

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