INT4894

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 5.93
Pain Relevance 21.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Anatomy Link Frequency
striatum 7
NAc 4
neurons 4
DRG 4
brain 2
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 106 100.00 Very High Very High Very High
Dynorphin 25 99.92 Very High Very High Very High
antagonist 18 99.84 Very High Very High Very High
Calcitonin gene-related peptide 6 99.84 Very High Very High Very High
Nucleus accumbens 28 99.82 Very High Very High Very High
Dopamine 121 99.70 Very High Very High Very High
Dorsal horn 5 99.54 Very High Very High Very High
Enkephalin 69 99.40 Very High Very High Very High
Spinal cord 13 99.30 Very High Very High Very High
nMDA receptor 5 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 8 99.52 Very High Very High Very High
Urological Neuroanatomy 2 98.66 Very High Very High Very High
Nervous System Injury 1 98.46 Very High Very High Very High
Bronchitis 3 98.00 Very High Very High Very High
Ganglion Cysts 8 97.90 Very High Very High Very High
Arthritis 8 96.72 Very High Very High Very High
Pain 7 95.00 High High
INFLAMMATION 19 94.96 High High
Injury 2 93.12 High High
Nociception 8 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of these studies was to determine if substance P (SP) content in the trachea or lungs was elevated in this animal model of chronic bronchitis, and whether an increase in SP content was associated with an increase in preprotachykinin gene-I (PPT) mRNA expression.
Transcription (expression) of PPT in lungs associated with bronchitis and substance p
1) Confidence 0.67 Published 1996 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8600937 Disease Relevance 0.35 Pain Relevance 0.38
No differences between HR and LR in mRNA levels for PPT, DYN, PPE or GAD were observed in the shell of the NACC.
Transcription (levels) of PPT in NACC associated with nucleus accumbens, dynorphin and generalized anxiety disorder
2) Confidence 0.60 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874516 Disease Relevance 0.57 Pain Relevance 0.57
In the medial frontal cortex and the dorsal striatum, no differences between HR and LR in mRNA levels for PPT, DYN, PPE, GAD or NT were found.
Transcription (levels) of PPT in dorsal associated with dynorphin, generalized anxiety disorder and urological neuroanatomy
3) Confidence 0.60 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874516 Disease Relevance 0.51 Pain Relevance 0.57
The present investigation assessed the effect of chronic blockade of kainate/quisqualate binding sites with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on preproenkephalin (PPE) and preprotachykinin (PPT) mRNA abundance in the neostriatum of the rat brain.
Transcription (abundance) of PPT in brain
4) Confidence 0.60 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7659290 Disease Relevance 0 Pain Relevance 0.11
Similarly, PPT mRNA abundance was significantly decreased in dlCPu, dmCPu and aCPu but not in the accumbens.
Transcription (abundance) of PPT mRNA
5) Confidence 0.57 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7659290 Disease Relevance 0 Pain Relevance 0.13
The experiments described in the present study approached nerve injury from both a biochemical and anatomical perspective by monitoring changes in expression of preprotachykinin (PPT) mRNA encoding the prototypic tachykinin substance P and related peptide species in neurons of the rat dorsal root ganglia (DRG) following unilateral chronic constriction injury of the sciatic nerve.
Transcription (expression) of PPT in neurons associated with nervous system injury, eae, injury, sciatic nerve and substance p
6) Confidence 0.56 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.41 Pain Relevance 0.25
PPT-A mRNA expression was not significantly affected by caffeine treatment in the CPu or NAc.
Transcription (expression) of PPT in NAc associated with nucleus accumbens
7) Confidence 0.52 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9280160 Disease Relevance 0.07 Pain Relevance 0.39
The precise role of 5-HT(2) receptor on PPT-A mRNA biosynthesis after a neonatal lesion should be clarified by further experiments using 5-HT(2) agonists.
Transcription (biosynthesis) of PPT associated with agonist
8) Confidence 0.52 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754083 Disease Relevance 0 Pain Relevance 0.39
It is established that dopamine (DA) controls the expression of preprodynorphin (PPDYN), preprotachykinin A (PPT-A) and preproenkephalin (PPE) mRNAs in striatal structures.
Transcription (expression) of PPT associated with dopamine
9) Confidence 0.52 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9526067 Disease Relevance 0 Pain Relevance 0.43
Following injection of adjuvant into the bilateral hind paws, the levels of PPT-A mRNA were significantly increased in the dorsal root ganglia at L4-L6 levels and the lumbar spinal cord, but not in the striatum, midbrain and medulla oblongata.
Transcription (levels) of PPT in striatum associated with medulla, midbrain and spinal cord
10) Confidence 0.52 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2469044 Disease Relevance 0.32 Pain Relevance 0.68
Finally, the absence of any effect of 5-HT(2) antagonist on the expression of PPT-A mRNA in intact animals is discussed.
Transcription (expression) of PPT associated with antagonist
11) Confidence 0.52 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754083 Disease Relevance 0 Pain Relevance 0.42
The cortical contribution to the maintenance of preproenkephalin (PPE) and preprotachykinin (PPT) mRNA levels in the rat striatum was investigated using quantitative in situ hybridization histochemistry.
Transcription (levels) of PPT in striatum
12) Confidence 0.51 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.18
The levels of Met5-enkephalin (ME) and substance P (SP) were determined by radioimmunoassay and preproenkephalin (PPE) and preprotachykinin (PPT) mRNA abundance in the striatum were assessed by hybridization analysis.
Transcription (abundance) of PPT in striatum associated with enkephalin and substance p
13) Confidence 0.49 Published 1990 Journal Brain Res. Section Abstract Doc Link 1707718 Disease Relevance 0 Pain Relevance 1.03
Striatal mRNA expression for preproenkephalin (PPE) and preprotachykinin (PPT) was studied in unilateral 6-OHDA lesioned rats treated subchronically with a range of selective and non-selective D-1 or D-2 dopamine (DA) agonists.
Transcription (expression) of PPT associated with dopamine and agonist
14) Confidence 0.48 Published 1996 Journal J Neural Transm Section Abstract Doc Link 8739837 Disease Relevance 0 Pain Relevance 0.32
IL-1beta increases SP synthesis by enhancing the expression of preprotachykinin (PPT) mRNA encoding for SP and other tachykinins in the DRG.
Transcription (expression) of PPT in DRG associated with substance p
15) Confidence 0.48 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0.10 Pain Relevance 0.41
The levels of ME and SP were determined by radioimmunoassay, and the abundance of preproenkephalin (PPE) and preprotachykinin (PPT) mRNA in the striatum was assessed by Northern blot hybridization analysis.
Transcription (abundance) of PPT in striatum associated with enkephalin and substance p
16) Confidence 0.48 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1707436 Disease Relevance 0 Pain Relevance 0.98
Following injection of either formalin or complete Freund's adjuvant (CFA) into one hindpaw, the levels of expression of NK-1 and NK-3 mRNAs in the spinal cord dorsal horn and preprotachykinin (PPT) mRNA expression in the lumbar dorsal root ganglia (DRG) were quantitated using solution hybridization-nuclease protection assays.
Transcription (expression) of PPT in dorsal root ganglia associated with dorsal horn and spinal cord
17) Confidence 0.47 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8301359 Disease Relevance 0.32 Pain Relevance 0.70
For determination of peptide encoding mRNAs distributed in DRG neurons, in situ hybridization histochemistry utilizing S-end-labeled oligonucleotides complimentary to sequences of preprosomatostatin (PPSOM), preprocalcitonin gene related peptide (PPCGRP), preprotachykinin (PPT), or preproneuropeptide Y (PPNPY) mRNA was performed.
Transcription (sequences) of PPT in neurons associated with dorsal root ganglion
18) Confidence 0.46 Published 1996 Journal Peptides Section Abstract Doc Link 8899822 Disease Relevance 1.29 Pain Relevance 0.64
The data demonstrate that non-NMDA receptor activity modulates basal levels of expression of PPE and PPT mRNAs in the neostriatum of the rat brain.
Transcription (expression) of PPT in brain associated with nmda receptor
19) Confidence 0.44 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7659290 Disease Relevance 0 Pain Relevance 0.13
Striatal preprotachykinin (PPT) mRNA levels were significantly increased 8 days following injection.
Transcription (levels) of PPT
20) Confidence 0.43 Published 1997 Journal Dev. Neurosci. Section Abstract Doc Link 9097028 Disease Relevance 0 Pain Relevance 0.40

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