INT4895

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 2.46
Pain Relevance 11.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tac4)
Anatomy Link Frequency
striatum 10
ventromedial hypothalamic nucleus 2
thoracic 2
DRG 2
dorsal horn 2
Tac4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 39 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
Dorsal horn 2 100.00 Very High Very High Very High
agonist 60 99.98 Very High Very High Very High
Enkephalin 13 99.84 Very High Very High Very High
Serotonin 48 99.72 Very High Very High Very High
Dopamine 101 99.58 Very High Very High Very High
Spinal cord 8 99.44 Very High Very High Very High
qutenza 13 99.10 Very High Very High Very High
opiate 12 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 1 96.96 Very High Very High Very High
Pain 8 93.64 High High
Nociception 6 93.64 High High
Pancreatitis 5 91.00 High High
Stress 1 90.72 High High
Nervous System Injury 1 90.20 High High
Hyperalgesia 1 90.00 High High
Acute Necrotizing Pancreatitis 1 89.16 High High
Neuropathic Pain 2 88.84 High High
INFLAMMATION 4 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we report that transection of the infraorbital nerve, a major branch of the maxillary nerve, causes exaggerated face grooming to normally innocuous mechanical stimuli in the skin territory of the uninjured mandibular nerve, and increases the expression of preprotachykinin mRNA in the primary afferent neurons in the mandibular zone in the trigeminal ganglia.
Positive_regulation (increases) of Gene_expression (expression) of preprotachykinin mRNA in afferent neurons
1) Confidence 0.69 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12809988 Disease Relevance 0.18 Pain Relevance 0.33
This study has demonstrated long-term graft-induced functional recovery coincident with normalization of striatal proenkephalin and preprotachykinin mRNA expression.
Positive_regulation (normalization) of Gene_expression (expression) of preprotachykinin mRNA
2) Confidence 0.50 Published 1993 Journal Exp. Neurol. Section Abstract Doc Link 8432341 Disease Relevance 0 Pain Relevance 0.12
We have previously demonstrated that the combined administration of dopamine(D1) and serotonin(2) receptor agonists to dopamine-depleted adult rats induced preprotachykinin mRNA expression within the periventricular rostral striatum to levels which were significantly different than what could be elicited by either agonist alone.
Positive_regulation (induced) of Gene_expression (expression) of preprotachykinin in striatum associated with dopamine, agonist and serotonin
3) Confidence 0.47 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516832 Disease Relevance 0 Pain Relevance 0.66
Furthermore, co-stimulation of dopamine(D1) and serotonin(2) receptors produced a nearly four-fold induction of preprotachykinin message levels in the dorsomedial striatum that was significantly greater than either agonist alone.
Positive_regulation (induction) of Gene_expression (produced) of preprotachykinin in striatum associated with dopamine, agonist and serotonin
4) Confidence 0.47 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516832 Disease Relevance 0 Pain Relevance 0.86
Application of both agonists also elevated preprotachykinin mRNA expression within the dorsolateral striatum, but to a lesser extent.
Positive_regulation (elevated) of Gene_expression (expression) of preprotachykinin in striatum associated with agonist
5) Confidence 0.47 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516832 Disease Relevance 0 Pain Relevance 0.89
Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6-hydroxydopamine-lesioned rat striatum parallels functional recovery.
Spec (Partial) Positive_regulation (reversal) of Gene_expression (reversal) of preprotachykinin in striatum associated with dopamine and enkephalin
6) Confidence 0.43 Published 1996 Journal Mov. Disord. Section Title Doc Link 8771066 Disease Relevance 0 Pain Relevance 0.27
Dopamine depletion appears to promote a synergistic interaction between dopamine(D1) and serotonin(2) receptors that leads to enhanced expression of striatal preprotachykinin mRNA levels.
Positive_regulation (enhanced) of Gene_expression (expression) of preprotachykinin associated with dopamine and serotonin
7) Confidence 0.38 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516832 Disease Relevance 0 Pain Relevance 0.76
Dopamine depletion appears to promote a synergistic interaction between dopamine(D1) and serotonin(2) receptors that leads to enhanced expression of striatal preprotachykinin mRNA levels.
Positive_regulation (leads) of Gene_expression (expression) of preprotachykinin associated with dopamine and serotonin
8) Confidence 0.38 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516832 Disease Relevance 0 Pain Relevance 0.76
However, the combined application of both agonists increased (+44%) preprotachykinin message levels, but these changes were restricted to the dorsomedial striatum.
Positive_regulation (increased) of Gene_expression (levels) of preprotachykinin in striatum associated with agonist
9) Confidence 0.38 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516832 Disease Relevance 0 Pain Relevance 0.91
It also potentiated the imbalance in preprotachykinin messenger RNA expression, mainly as a result of an increase of preprotachykinin messenger RNA levels in the intact neostriatum.
Positive_regulation (potentiated) of Gene_expression (expression) of preprotachykinin
10) Confidence 0.25 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637873 Disease Relevance 0 Pain Relevance 0.04
The universal opiate receptor antagonist naltrexone and the delta-opiate receptor antagonist naltrindole each potentiated the estrogen-induced increase and elevated cholecystokinin messenger RNA levels an additional 1.9- to 2.8-fold depending on the nucleus examined, but had no effect on the estrogen-induced expression of either preproenkephalin or preprotachykinin messenger RNA. beta-Funaltrexamine, a mu-opiate receptor antagonist, had no effect on the medial preoptic or medial amygdaloid cholecystokinin messenger RNA levels or on the estrogen-induced expression of preproenkephalin messenger RNA but did cause a decrease in estrogen-induced cholecystokinin messenger RNA levels in the bed nucleus of the stria terminalis and a decrease in the preprotachykinin messenger RNA levels in the ventromedial hypothalamic nucleus.
Positive_regulation (induced) of Gene_expression (expression) of preprotachykinin in ventromedial hypothalamic nucleus associated with antagonist, opiate and cholecystokinin
11) Confidence 0.09 Published 1997 Journal Neuroscience Section Abstract Doc Link 9284350 Disease Relevance 0.05 Pain Relevance 1.58
Using in situ hybridization we found marked increases in expression of beta-preprotachykinin (PPT; 81 +/- 24% rise) and alpha-CGRP (44 +/- 6% rise) mRNAs in innervating (ipsilateral L5) DRG neurones only.
Positive_regulation (increases) of Gene_expression (expression) of beta-preprotachykinin in DRG associated with calcitonin gene-related peptide
12) Confidence 0.08 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1281253 Disease Relevance 0.42 Pain Relevance 0.69
This referred mechanical sensitivity was associated with an 8-fold increase in levels of phosphorylated trkA in the pancreas and with significant up-regulation of both calcitonin gene-related peptide and preprotachykinin mRNA expression in thoracic dorsal root ganglia and with increased calcitonin gene-related peptide and substance P immunoreactivity in spinal cord segment T10.
Positive_regulation (up-regulation) of Gene_expression (expression) of preprotachykinin mRNA in thoracic associated with spinal cord, substance p and calcitonin gene-related peptide
13) Confidence 0.08 Published 2003 Journal J Pain Section Abstract Doc Link 14622690 Disease Relevance 0.85 Pain Relevance 0.61
We measured expression of preprotachykinin mRNA and NK-1 receptor mRNA following intrathecally administered substance P(1-7) (SP1-7), the major metabolite of SP in rat, and following capsaicin, a compound known to induce release of endogenous SP.
Positive_regulation (following) of Gene_expression (expression) of preprotachykinin mRNA associated with qutenza and substance p
14) Confidence 0.07 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12169105 Disease Relevance 0.36 Pain Relevance 1.41
Six hours after hindpaw treatment, the levels of substance P-encoding preprotachykinin messenger RNA in the lumbar dorsal root ganglia and neurokinin B, neurokinin-1 receptor and neurokinin-3 receptor messenger RNAs in the lumbar dorsal horn were increased by approximately two-fold as compared to sham-treated controls.
Positive_regulation (increased) of Gene_expression (levels) of preprotachykinin in dorsal horn associated with dorsal horn and substance p
15) Confidence 0.06 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536308 Disease Relevance 0.49 Pain Relevance 1.06
RNA interference prevents lipopolysaccharide-induced preprotachykinin gene expression.
Positive_regulation (induced) of Gene_expression (expression) of preprotachykinin gene associated with qutenza
16) Confidence 0.06 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 14613715 Disease Relevance 0.10 Pain Relevance 0.42
Lipopolysaccharide induces preprotachykinin gene expression.
Positive_regulation (induces) of Gene_expression (expression) of preprotachykinin gene
17) Confidence 0.05 Published 2003 Journal Am. J. Respir. Cell Mol. Biol. Section Title Doc Link 12738685 Disease Relevance 0 Pain Relevance 0.14

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