INT48952

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2011
Negated 3
Speculated 5
Reported most in Abstract
Documents 204
Total Number 209
Disease Relevance 101.73
Pain Relevance 53.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
colon 7
neutrophil 5
neuronal 5
RAW 264 5
liver 4
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1152 100.00 Very High Very High Very High
cytokine 289 100.00 Very High Very High Very High
Pain 76 100.00 Very High Very High Very High
COX2 52 100.00 Very High Very High Very High
Analgesic 50 100.00 Very High Very High Very High
nociceptor 15 100.00 Very High Very High Very High
dexamethasone 17 99.98 Very High Very High Very High
aspirin 58 99.92 Very High Very High Very High
Inflammatory mediators 90 99.86 Very High Very High Very High
diclofenac 20 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1398 100.00 Very High Very High Very High
Peptic Ulcer 4 100.00 Very High Very High Very High
Injury 553 99.92 Very High Very High Very High
Bardet-biedl Syndrome 6 99.92 Very High Very High Very High
Sepsis 206 99.84 Very High Very High Very High
Arthritis 58 99.84 Very High Very High Very High
Inflammatory Pain 9 99.82 Very High Very High Very High
Frailty 514 99.80 Very High Very High Very High
Cv General 4 Under Development 21 99.78 Very High Very High Very High
Increased Venous Pressure Under Development 53 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain.
Negative_regulation (inhibitor) of iNOS associated with inflammation, analgesic and neuropathic pain
1) Confidence 0.59 Published 2006 Journal Pain Section Title Doc Link 16360270 Disease Relevance 1.15 Pain Relevance 0.93
Arginine uptake and metabolism studies revealed that the inhibitory effects of aminoguanidine were due predominantly to inhibition of iNOS enzyme activity.
Negative_regulation (inhibition) of iNOS
2) Confidence 0.58 Published 1998 Journal Hepatology Section Abstract Doc Link 9500703 Disease Relevance 0.45 Pain Relevance 0.76
Aspirin dose dependently inhibited iNOS enzymatic activity, whereas salicylate and dexamethasone had limited effect.
Negative_regulation (inhibited) of iNOS associated with aspirin and dexamethasone
3) Confidence 0.58 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.12 Pain Relevance 0.69
The present study demonstrates that 1) inhibitory effect of dexamethasone on cytokine-induced iNOS expression and NO production in rat VSMCs, although potentially acting at multiple levels, is partly mediated by inhibition of NF-kappaB activation resulting from decreased phosphorylation and degradation of IkappaB-alpha, 2) both salicylate and aspirin inhibit cytokine-stimulated NO production at translational and/or posttranslational levels without affecting NF-kappaB- mediated iNOS gene expression, and 3) aspirin directly inhibits iNOS enzyme activity.
Negative_regulation (inhibits) of iNOS associated with aspirin, dexamethasone and cytokine
4) Confidence 0.58 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0 Pain Relevance 0.62
The iNOS mRNA, but not the eNOS, was reduced.
Negative_regulation (reduced) of iNOS
5) Confidence 0.58 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15821434 Disease Relevance 0.67 Pain Relevance 0.08
Ibuprofen concentration-dependently decreased iNOS mRNA levels, with an IC50 > 2 mM.
Negative_regulation (decreased) of iNOS
6) Confidence 0.58 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406924 Disease Relevance 0.17 Pain Relevance 0.29
In addition to inhibiting cyclooxygenase (COX), the NSAIDs have recently been shown to decrease inducible nitric oxide synthase (iNOS) activity.
Negative_regulation (decrease) of iNOS associated with cinod
7) Confidence 0.58 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406924 Disease Relevance 0.18 Pain Relevance 0.38
Analysis of proximal and distal colon tissue from 8- and 28-week rat/azoxymethane studies showed that GT-094 treatment reduced colon crypt proliferation by 30% to 69%, reduced inducible NO synthase (iNOS) levels by 33% to 67%, reduced poly(ADP-ribose)polymerase-1 expression and cleavage 2- to 4-fold, and elevated levels of p27 in the distal colon 3-fold.
Negative_regulation (reduced) of inducible NO synthase in colon
8) Confidence 0.58 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17699720 Disease Relevance 1.06 Pain Relevance 0.57
Analysis of proximal and distal colon tissue from 8- and 28-week rat/azoxymethane studies showed that GT-094 treatment reduced colon crypt proliferation by 30% to 69%, reduced inducible NO synthase (iNOS) levels by 33% to 67%, reduced poly(ADP-ribose)polymerase-1 expression and cleavage 2- to 4-fold, and elevated levels of p27 in the distal colon 3-fold.
Negative_regulation (reduced) of iNOS in colon
9) Confidence 0.58 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17699720 Disease Relevance 1.06 Pain Relevance 0.58
Pretreatment with aminoguanidine or dexamethasone, inhibitors of inducible NO synthase (iNOS), prevented the increase in UNOXV and UcGMPV but had no impact on mean arterial pressure (BP), renal vascular resistance (RVR) or GFR.
Negative_regulation (inhibitors) of iNOS associated with dexamethasone
10) Confidence 0.58 Published 1997 Journal Kidney Int. Section Abstract Doc Link 9186887 Disease Relevance 0.06 Pain Relevance 0.05
OBJECTIVES: The objective of this study was to examine the effects of rofecoxib, meloxicam, both cyclooxygenase-2 (COX-2) inhibitors and aminoguanidine hydrochloride, an inducible nitric oxide synthase (iNOS) inhibitor and their combinations in neuropathic pain in rats.
Negative_regulation (inhibitor) of iNOS associated with neuropathic pain
11) Confidence 0.57 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16920373 Disease Relevance 0.17 Pain Relevance 0.17
The present study was undertaken to evaluate the effect of ONO-1714, a potent and specific inhibitor of inducible NO synthase (iNOS), on acetaminophen-induced hepatotoxicity in the rats.
Negative_regulation (inhibitor) of iNOS associated with paracetamol and hepatotoxicity
12) Confidence 0.56 Published 2003 Journal Life Sci. Section Abstract Doc Link 14654171 Disease Relevance 0.46 Pain Relevance 0.36
Moreover, the protective effects of ketamine are mediated, at least in part, through a reduction in COX-2 and iNOS protein that could be regulated via changes in NF-kappaB-binding activity.


Negative_regulation (reduction) of iNOS protein
13) Confidence 0.55 Published 2005 Journal Surgery Section Body Doc Link 16153419 Disease Relevance 0 Pain Relevance 0
Furthermore, there seems a dose related correlation between the inhibition of NO production and the inhibitions of iNOS mRNA and iNOS protein expressions by WJL in RAW 264.7 cells.
Negative_regulation (inhibitions) of iNOS in RAW 264
14) Confidence 0.54 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0.19 Pain Relevance 0
These studies implicate cardiac fibroblasts as a source of NO in inflammatory cardiac diseases and suggest a possible therapeutic role for salicylate and aspirin in diminishing the steady state levels of iNOS mRNA.
Negative_regulation (diminishing) of iNOS in fibroblasts associated with aspirin, inflammation and heart disease
15) Confidence 0.52 Published 1996 Journal Circ. Res. Section Abstract Doc Link 8620595 Disease Relevance 0.20 Pain Relevance 0.35
Administration of the highly selective iNOS inhibitor, GW273629 ((R)-2-amino-4,4-dioxo-6(1-iminioethylamino)-4-thiahexanoic acid; 5 mg kg(-1), s.c.), 18 h after indomethacin, likewise prevented the intestinal lesions and attenuated the microvascular leakage.
Negative_regulation (inhibitor) of iNOS
16) Confidence 0.51 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11698048 Disease Relevance 0.36 Pain Relevance 0.22
Effects of ultrasound and diclofenac phonophoresis on inflammatory pain relief: suppression of inducible nitric oxide synthase in arthritic rats.
Negative_regulation (suppression) of inducible nitric oxide synthase associated with ipn, diclofenac and arthritis
17) Confidence 0.51 Published 2006 Journal Phys Ther Section Title Doc Link 16386061 Disease Relevance 0.39 Pain Relevance 0.38
Naltrexone induced a pronounced dose-dependent reduction in iNOS mRNA and protein expression by splenocytes.
Negative_regulation (reduction) of iNOS mRNA
18) Confidence 0.51 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918551 Disease Relevance 0 Pain Relevance 0.48
After LPS application, iNOS mRNA was first detected after 3 hrs, peaked at 6 hrs, and decreased thereafter. iNOS-positive cells were macrophages and neutrophils.
Negative_regulation (decreased) of iNOS in neutrophils
19) Confidence 0.51 Published 2005 Journal J. Dent. Res. Section Abstract Doc Link 16040737 Disease Relevance 0.60 Pain Relevance 0.61
Production of nitric oxide by cells from both control and acetaminophen-treated rats was blocked by aminoguanidine, a relatively specific inhibitor of iNOS.
Negative_regulation (inhibitor) of iNOS associated with paracetamol
20) Confidence 0.51 Published 1998 Journal Hepatology Section Abstract Doc Link 9500703 Disease Relevance 0.45 Pain Relevance 0.77

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