INT48953

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2011
Negated 14
Speculated 30
Reported most in Abstract
Documents 486
Total Number 517
Disease Relevance 239.85
Pain Relevance 131.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
neuronal 15
macrophages 14
liver 10
medulla 10
microglia 10
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2263 100.00 Very High Very High Very High
cytokine 860 100.00 Very High Very High Very High
Inflammatory mediators 178 100.00 Very High Very High Very High
Snapping jaw 126 100.00 Very High Very High Very High
COX2 125 100.00 Very High Very High Very High
Analgesic 98 100.00 Very High Very High Very High
Opioid 53 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 22 100.00 Very High Very High Very High
Dorsal horn 362 99.98 Very High Very High Very High
metalloproteinase 52 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2659 100.00 Very High Very High Very High
Cancer 146 100.00 Very High Very High Very High
Necrosis 140 100.00 Very High Very High Very High
Ulcers 137 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 125 100.00 Very High Very High Very High
Urological Neuroanatomy 71 100.00 Very High Very High Very High
Functional Bowel Disorder 51 100.00 Very High Very High Very High
Diabetes Mellitus 1687 99.98 Very High Very High Very High
Disease 837 99.92 Very High Very High Very High
Adenocarcinoma 29 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, iNOS mRNA levels were not elevated significantly in all tissues examined at 24 h.
Neg (not) Positive_regulation (elevated) of iNOS mRNA
1) Confidence 0.70 Published 2006 Journal Life Sci. Section Abstract Doc Link 16181643 Disease Relevance 0.32 Pain Relevance 0.17
The data showed that a significant increase in iNOS mRNA levels was found in the spleen, lung, liver, with slight elevation in the heart and kidney at 3 h after LPS administration.
Positive_regulation (increase) of iNOS mRNA in liver
2) Confidence 0.70 Published 2006 Journal Life Sci. Section Abstract Doc Link 16181643 Disease Relevance 0.35 Pain Relevance 0.17
We evaluated the contribution of peroxynitrite to the fatal cardiovascular depression induced by overproduction of nitric oxide (NO) after activation of inducible NO synthase (iNOS) in the rostral ventrolateral medulla (RVLM), the origin of sympathetic vasomotor tone.
Positive_regulation (activation) of iNOS in sympathetic associated with rostral ventrolateral medulla, depression and cardiovascular disorder under development
3) Confidence 0.70 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384174 Disease Relevance 0.33 Pain Relevance 0.42
We evaluated the contribution of peroxynitrite to the fatal cardiovascular depression induced by overproduction of nitric oxide (NO) after activation of inducible NO synthase (iNOS) in the rostral ventrolateral medulla (RVLM), the origin of sympathetic vasomotor tone.
Positive_regulation (activation) of inducible NO synthase in sympathetic associated with rostral ventrolateral medulla, depression and cardiovascular disorder under development
4) Confidence 0.70 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384174 Disease Relevance 0.33 Pain Relevance 0.41
Increased nitrite production was accompanied by increased NOS2 catalytic activity, steady state mRNA levels, and promoter activation.
Positive_regulation (increased) of NOS2
5) Confidence 0.70 Published 2001 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 11294465 Disease Relevance 0.17 Pain Relevance 0.41
Elevated NO synthesis occurred in parallel with increased inducible NO synthase (iNOS) enzyme activity and mass, steady-state levels of iNOS mRNA, increased transcription of the iNOS gene, and increased iNOS promoter activity.
Neg (NO) Positive_regulation (increased) of iNOS
6) Confidence 0.69 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262377 Disease Relevance 0.56 Pain Relevance 0.23
This study shows by Northern blot analysis that during experimental allergic neuritis (EAN), at the beginning of clinical signs, there is a transient extensive iNOS mRNA induction in nerve roots, in which morphology is mainly characterized by severe demyelination, but not in sciatic nerve, where scattered axonal degeneration is evident.
Positive_regulation (induction) of iNOS in sciatic nerve associated with demyelination, experimental autoimmune neuritis, sciatic nerve and neuritis
7) Confidence 0.69 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15144861 Disease Relevance 0.86 Pain Relevance 0.58
The induction in vitro of inducible nitric oxide synthase (iNOS) in intact gastric circular (CM) and longitudinal (LM) smooth muscle preparations was evaluated 1) pharmacologically, by the appearance of 1 mM L-arginine (L-Arg)-induced relaxation in a precontracted tissue; 2) biochemically, according to the appearance of iNOS mRNA using a reverse transcriptase-polymerase chain reaction; and 3) immunohistochemically, using an iNOS-specific antibody.
Positive_regulation (induction) of iNOS in smooth muscle
8) Confidence 0.69 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9374708 Disease Relevance 0 Pain Relevance 0
OBJECTIVES: The present study tests whether environmental stimuli paired with the administration of heroin alter the expression of inducible nitric oxide synthase (iNOS), one of the isoforms of the enzyme responsible for nitric oxide production.
Spec (whether) Positive_regulation (inducible) of iNOS
9) Confidence 0.69 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 12457272 Disease Relevance 0 Pain Relevance 0
This expression continued to increase in the perineurium of 5-month proximal and compressed nerve segments with distal nerve demonstrating only a slight up-regulation of iNOS mRNA.
Positive_regulation (up-regulation) of iNOS mRNA in proximal
10) Confidence 0.69 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12908928 Disease Relevance 0.07 Pain Relevance 0.07
As recent evidence has shown that an alteration in reactive oxidative species (ROS) is related to neural degradation and regeneration, we evaluated whether inducible nitric oxide synthase (iNOS) plays a role in a rat model for CNC.
Spec (whether) Positive_regulation (inducible) of iNOS in neural
11) Confidence 0.69 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12908928 Disease Relevance 0.07 Pain Relevance 0.07
The oxidative stress proteins inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) are upregulated in the liver during sepsis but have opposite roles.
Positive_regulation (upregulated) of iNOS in liver associated with stress and sepsis
12) Confidence 0.69 Published 2005 Journal J Trauma Section Abstract Doc Link 15824646 Disease Relevance 0.73 Pain Relevance 0.34
Because nitric oxide (NO) can contribute to oxidative stress and because the inducible isoform of NO synthase (iNOS) is often upregulated in association with tissue injury, we hypothesized that iNOS-derived NO participates in the pulmonary vascular wall injury at the onset of hypoxic pulmonary hypertension.
Positive_regulation (upregulated) of iNOS associated with stress, hypoxia, hypertension and injury
13) Confidence 0.69 Published 2006 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 16113050 Disease Relevance 0.97 Pain Relevance 0.10
The present study was performed to investigate whether increases in nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) were involved in impairment of learning behavior and hippocampal long-term potentiation (LTP) following transient ischemia.
Spec (whether) Positive_regulation (increases) of iNOS associated with ischemia and long-term potentiation
14) Confidence 0.69 Published 2001 Journal Behav. Brain Res. Section Abstract Doc Link 11182164 Disease Relevance 0.17 Pain Relevance 0.33
Expression of inducible NO synthase (iNOS) in synovia was detected by immunostaining.
Positive_regulation (inducible) of iNOS
15) Confidence 0.68 Published 2006 Journal Osteoarthr. Cartil. Section Body Doc Link 16580848 Disease Relevance 0.32 Pain Relevance 0
The activation of iNOS is evidently important in inflammatory arthritis (Farrell 1992; Pelletier et al., 1999). iNOS has been detected in the synovial tissue of a TMJ with internal derangement (Takahashi et al., 1996; Homma 2001).
Positive_regulation (activation) of iNOS in internal associated with snapping jaw, inflammation and arthritis
16) Confidence 0.68 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998788 Disease Relevance 1.03 Pain Relevance 0.91
It appears that the trigger effect is not dependent on the activity of iNOS or COX-2 but the late phase of cardioprotection is dependent on the upregulation of these enzymes.
Neg (not) Positive_regulation (dependent) of iNOS
17) Confidence 0.68 Published 2004 Journal Life Sci. Section Abstract Doc Link 15120566 Disease Relevance 0.14 Pain Relevance 0.75
Lipopolysaccharide (LPS)-induced hypotension and impaired aortic contraction to norepinephrine (NE) are thought to be consequent to induction of nitric oxide synthase (iNOS).
Positive_regulation (induction) of iNOS associated with pressure volume 2 under development
18) Confidence 0.68 Published 1996 Journal Shock Section Abstract Doc Link 8946653 Disease Relevance 0.42 Pain Relevance 0.26
Immunoblotting analysis revealed that lipopolysaccharide increased the protein level of inducible nitric oxide synthase (iNOS).
Positive_regulation (increased) of iNOS
19) Confidence 0.68 Published 2003 Journal Arch. Toxicol. Section Abstract Doc Link 12851743 Disease Relevance 0.09 Pain Relevance 0.07
RESULTS: The best induction of NOS II was achieved by the intravitreal administration of LPS.
Positive_regulation (induction) of NOS II
20) Confidence 0.67 Published 2004 Journal Inflamm. Res. Section Body Doc Link 15167974 Disease Relevance 0.08 Pain Relevance 0

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