INT48955

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2011
Negated 34
Speculated 23
Reported most in Abstract
Documents 753
Total Number 776
Disease Relevance 403.87
Pain Relevance 208.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 36
spinal cord 26
RAW 264 21
brain 18
glial cells 17
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 6012 100.00 Very High Very High Very High
cytokine 2574 100.00 Very High Very High Very High
Inflammatory response 490 100.00 Very High Very High Very High
Pain 454 100.00 Very High Very High Very High
Snapping jaw 181 100.00 Very High Very High Very High
COX2 172 100.00 Very High Very High Very High
Inflammatory marker 68 100.00 Very High Very High Very High
nociceptor 35 100.00 Very High Very High Very High
Dorsal horn 521 99.98 Very High Very High Very High
local anesthetic 21 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7166 100.00 Very High Very High Very High
Pain 562 100.00 Very High Very High Very High
Cancer 352 100.00 Very High Very High Very High
Necrosis 253 100.00 Very High Very High Very High
Nociception 192 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 175 100.00 Very High Very High Very High
Gastrointestinal Neoplasms 28 99.98 Very High Very High Very High
Drug Induced Neurotoxicity 247 99.96 Very High Very High Very High
Urological Neuroanatomy 105 99.92 Very High Very High Very High
Disease 2882 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study tests the hypothesis that expression of inducible nitric oxide synthase (iNOS) is modulated by the administration of the morphine metabolite, morphine-6beta-glucuronide.
Gene_expression (expression) of iNOS associated with morphine
1) Confidence 0.78 Published 2001 Journal Inflammation Section Abstract Doc Link 11580103 Disease Relevance 0 Pain Relevance 0.67
The initial study using rats shows that morphine-6beta-glucuronide administration (0, 1.0, 3.163, 10 mg/kg s.c.) results in a pronounced reduction in lipopolysaccharide (LPS)-induced expression of iNOS (inducible nitricoxide synthease) in spleen, lung, and liver tissue as measured by western blotting.
Gene_expression (expression) of iNOS in liver associated with morphine
2) Confidence 0.78 Published 2001 Journal Inflammation Section Abstract Doc Link 11580103 Disease Relevance 0 Pain Relevance 0.88
The present study tests the hypothesis that expression of inducible nitric oxide synthase (iNOS) is modulated by the administration of heroin.
Gene_expression (expression) of iNOS
3) Confidence 0.78 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10741899 Disease Relevance 0.19 Pain Relevance 0.06
Pre-treatment with ampicillin (200 mg kg(-1) day(-1), p.o.), metronidazole (200 mg kg(-1) day(-1), p.o.), or polymixin B (15 mg kg(-1) day(-1), s.c.), inhibited indomethacin-induced lesion formation, reduced microvascular leakage and prevented the expression of iNOS activity.
Gene_expression (expression) of iNOS
4) Confidence 0.78 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11698048 Disease Relevance 0.36 Pain Relevance 0.21
The high-output, inducible isoform of nitric oxide (NO) synthase (iNOS) is expressed in rat brain after immobilisation stress and its inhibition protects against cell damage in this condition.
Gene_expression (expressed) of iNOS in brain associated with stress
5) Confidence 0.78 Published 2002 Journal Neuroreport Section Abstract Doc Link 11893913 Disease Relevance 0.35 Pain Relevance 0.27
The results suggest that local NO production by activation of iNOS mRNA expression and cytokine release may contribute to LPS-induced organ dysfunction at various time points.
Gene_expression (expression) of iNOS mRNA associated with cytokine
6) Confidence 0.78 Published 2006 Journal Life Sci. Section Abstract Doc Link 16181643 Disease Relevance 0.28 Pain Relevance 0.17
There was also a discernible elevation of iNOS expression in the ventrolateral medulla, followed by a massive production of nitrotyrosine, an experimental index for peroxynitrite.
Gene_expression (expression) of iNOS in medulla associated with medulla
7) Confidence 0.78 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384174 Disease Relevance 0.35 Pain Relevance 0.43
The purpose of this study was to investigate the peripheral influences of US and phonophoresis on the modulation of spinal inducible nitric oxide synthase (iNOS) expression elicited by hind paw stimulation with an ankle injection of complete Freund adjuvant (CFA).
Gene_expression (expression) of iNOS in ankle associated with freund adjuvant
8) Confidence 0.78 Published 2006 Journal Phys Ther Section Abstract Doc Link 16386061 Disease Relevance 0.33 Pain Relevance 0.33
The authors tested the effects of four local anesthetics on the expression of NOS2 in immunostimulated rat C6 glioma cells.
Gene_expression (expression) of NOS2 associated with glioma and local anesthetic
9) Confidence 0.78 Published 2001 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 11294465 Disease Relevance 0.29 Pain Relevance 0.43
These results demonstrate that submillimolar doses of two commonly used local anesthetics can increase glial NOS2 expression.
Gene_expression (expression) of NOS2 associated with local anesthetic
10) Confidence 0.78 Published 2001 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 11294465 Disease Relevance 0.05 Pain Relevance 0.35
Expression of the calcium-independent nitric oxide synthase (NOS2) contributes to damage in neurologic disease and trauma.
Gene_expression (Expression) of NOS2 associated with injury and disease
11) Confidence 0.78 Published 2001 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 11294465 Disease Relevance 0.28 Pain Relevance 0.38
In this paper we examined the effects of KE on nitric oxide (NO) production, expression of inducible nitric oxide synthase (iNOS), osteoblast and osteoclast activity.
Gene_expression (expression) of iNOS in osteoclast associated with osteoporosis
12) Confidence 0.78 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18520054 Disease Relevance 0.89 Pain Relevance 0.16
In this study we investigated the local expression of the inducible isoform of nitric oxide synthase (iNOS) following a chronic constriction injury (CCI) to the sciatic nerve, a rat model of neuropathic pain.
Spec (investigated) Gene_expression (expression) of iNOS in sciatic nerve associated with eae, injury, neuropathic pain and sciatic nerve
13) Confidence 0.78 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10076904 Disease Relevance 0.92 Pain Relevance 0.58
In the present study, we tested the hypothesis that lipopolysaccharide (LPS)-induced expression of nitric oxide synthase (iNOS) by splenocytes is modulated through the activation of endogenous opioids in the central nervous system.
Gene_expression (expression) of iNOS in central nervous system associated with endogenous opioid and central nervous system
14) Confidence 0.78 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918551 Disease Relevance 0 Pain Relevance 0.22
Both iNOS mRNA and protein expression was detectable at the 2-h time point, with peak expression occurring at 8 h.
Gene_expression (expression) of iNOS mRNA
15) Confidence 0.78 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918551 Disease Relevance 0 Pain Relevance 0.44
Therefore, it may be useful in clarifying the biological role of iNOS expression on Barrett's esophagus-associated adenocarcinoma to study the effect of iNOS inhibitor on animal esophageal adenocarcinoma model.
Gene_expression (expression) of iNOS in esophagus associated with adenocarcinoma
16) Confidence 0.78 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808576 Disease Relevance 0.89 Pain Relevance 0.03
Aberrant iNOS expression may be one of the phenotypical changes in gene expression associated with carcinogenesis of esophageal adenocarcinoma.
Gene_expression (expression) of iNOS associated with adenocarcinoma
17) Confidence 0.78 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808576 Disease Relevance 0.32 Pain Relevance 0
Expression of nitric oxide synthase type II in the spinal cord under conditions producing thermal hyperalgesia.
Gene_expression (Expression) of nitric oxide synthase type II in spinal cord associated with nociceptor, thermal hyperalgesia and spinal cord
18) Confidence 0.77 Published 1996 Journal J. Chem. Neuroanat. Section Title Doc Link 8811427 Disease Relevance 0.28 Pain Relevance 0.73
These results provide evidence for induction of NOS II expression under conditions producing thermal hyperalgesia and suggest a possible role in this behavior for the production of NO by a variety of cell types in the CNS.
Gene_expression (expression) of NOS II associated with thermal hyperalgesia
19) Confidence 0.77 Published 1996 Journal J. Chem. Neuroanat. Section Abstract Doc Link 8811427 Disease Relevance 0.30 Pain Relevance 0.63
Whether the expression of inducible nitric oxide synthase (iNOS) is affected by exercise is unknown.
Gene_expression (expression) of iNOS
20) Confidence 0.77 Published 2002 Journal J. Biomed. Sci. Section Abstract Doc Link 11914582 Disease Relevance 0 Pain Relevance 0.07

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