INT48960

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Context Info
Confidence 0.68
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 4.41
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SCG2) extracellular region (SCG2) intracellular (SCG2)
Anatomy Link Frequency
synovium 3
Nasal 2
cerebrospinal fluid 1
fibroblasts 1
brain stem 1
SCG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 46 100.00 Very High Very High Very High
c fibre 1 99.16 Very High Very High Very High
substantia gelatinosa 2 98.76 Very High Very High Very High
rheumatoid arthritis 8 98.60 Very High Very High Very High
qutenza 10 98.48 Very High Very High Very High
Fibrositis 2 98.44 Very High Very High Very High
substance P 20 98.36 Very High Very High Very High
Pain 9 97.78 Very High Very High Very High
Osteoarthritis 8 97.60 Very High Very High Very High
Inflammation 6 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Carcinoma 3 99.88 Very High Very High Very High
Rhinitis 3 99.12 Very High Very High Very High
Neuroendocrine Cancer 2 98.80 Very High Very High Very High
Rheumatoid Arthritis 12 98.60 Very High Very High Very High
Sleep Disorders 1 98.44 Very High Very High Very High
Pain 8 97.78 Very High Very High Very High
Osteoarthritis 8 97.60 Very High Very High Very High
INFLAMMATION 6 96.48 Very High Very High Very High
Cancer 10 93.20 High High
Ganglion Cysts 4 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: The neuropeptide secretoneurin, with potential relevance to leukocyte trafficking, is present in nerves of the nasal mucosa in allergic rhinitis and may be released in response to allergen and histamine exposure.
Gene_expression (present) of secretoneurin in leukocyte associated with rhinitis and neuropeptide
1) Confidence 0.68 Published 2005 Journal Allergy Section Abstract Doc Link 15727576 Disease Relevance 0.10 Pain Relevance 0.12
This study demonstrated that secretoneurin is distinctly distributed in the human brain stem.
Gene_expression (distributed) of secretoneurin in brain stem
2) Confidence 0.68 Published 1994 Journal J. Chem. Neuroanat. Section Abstract Doc Link 7532949 Disease Relevance 0 Pain Relevance 0.41
Significantly, peptide profiling provided novel insight into newly identified peptide products derived from proenkephalin, pro-NPY, proSAAS, CgA, CgB, and SCG2 prohormones.
Gene_expression (prohormones) of SCG2
3) Confidence 0.65 Published 2010 Journal J. Proteome Res. Section Abstract Doc Link 20704348 Disease Relevance 0.22 Pain Relevance 0.10
Nasal capsaicin challenge produced local pain (P <0.05) and increased the levels of fucose (P <0.05), but failed to affect the levels of secretoneurin.
Gene_expression (levels) of secretoneurin in Nasal
4) Confidence 0.60 Published 2005 Journal Allergy Section Body Doc Link 15727576 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: We conclude that secretoneurin is present in healthy human airways and that histamine evokes its release in both nasal and bronchial mucosae.
Gene_expression (present) of secretoneurin in nasal
5) Confidence 0.60 Published 2005 Journal Allergy Section Body Doc Link 15727576 Disease Relevance 0 Pain Relevance 0
Secretoneurin is a 33-amino acid neuropeptide produced by endoproteolytic processing from secretogranin II, which is a member of the chromogranin/ secretogranin family.
Gene_expression (produced) of Secretoneurin associated with neuropeptide
6) Confidence 0.60 Published 1997 Journal Synapse Section Abstract Doc Link 9131771 Disease Relevance 0 Pain Relevance 0.23
Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers.
Gene_expression (found) of secretogranin II associated with c fibre
7) Confidence 0.60 Published 1993 Journal FEBS Lett. Section Abstract Doc Link 8224224 Disease Relevance 0 Pain Relevance 0.30
This study indicates that secretoneurin is present in the uterus in C-afferent nerve fibers whose cell bodies are located in sensory ganglia.
Gene_expression (present) of secretoneurin in ganglia
8) Confidence 0.58 Published 2000 Journal Neuroscience Section Abstract Doc Link 10619482 Disease Relevance 0.16 Pain Relevance 0.39
Secretoneurin is a novel 33-amino-acid neuropeptide produced by endoproteolytic processing from secretogranin II, which is a member of the chromogranin/secretogranin family.
Gene_expression (produced) of Secretoneurin associated with neuropeptide
9) Confidence 0.56 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7745136 Disease Relevance 0.07 Pain Relevance 0.29
OBJECTIVE: Because former investigations have reported abnormal changes in the expression of serotonin (5-hydroxytryptamine [5-HT]) and substance P (SP) in serum and cerebrospinal fluid, this study sought to determine whether 5-HT and pain-modulating neuropeptides (SP, galanin [GA], pituitary adenylyl cyclase-activating polypeptide, and secretoneurin) were expressed abnormally in the muscle tissue of patients with fibromyalgia (FM).
Gene_expression (expressed) of secretoneurin in cerebrospinal fluid associated with pain, neuropeptide, fibrositis, serotonin and substance p
10) Confidence 0.46 Published 1998 Journal Arthritis Rheum. Section Abstract Doc Link 9751103 Disease Relevance 0.20 Pain Relevance 0.46
In this study we examined the possible participation of a novel peptide, secretoneurin (a cleavage product of secretogranin II), in regulation of sympathetic outflow to head and neck by using a retrograde labelling-technique combined with immunohistochemistry.
Gene_expression (product) of secretoneurin in head
11) Confidence 0.46 Published 1995 Journal J. Chem. Neuroanat. Section Abstract Doc Link 8527038 Disease Relevance 0.09 Pain Relevance 0.37
Expression of the precursor of secretoneurin, secretogranin II, in the synovium of patients with rheumatoid arthritis and osteoarthritis.
Gene_expression (Expression) of secretogranin II in synovium associated with neuropeptide, rheumatoid arthritis and osteoarthritis
12) Confidence 0.40 Published 2000 Journal J. Rheumatol. Section Title Doc Link 11036828 Disease Relevance 0.38 Pain Relevance 0.46
As secretogranin II (SGII) is the precursor of SN, we investigated expression of SGII mRNA and SN protein in the synovium of patients with rheumatoid arthritis (RA) and osteoarthritis (OA).
Spec (investigated) Gene_expression (expression) of SGII mRNA in synovium associated with rheumatoid arthritis and osteoarthritis
13) Confidence 0.40 Published 2000 Journal J. Rheumatol. Section Abstract Doc Link 11036828 Disease Relevance 0.63 Pain Relevance 0.36
CONCLUSION: The expression of SGII mRNA in RA and OA synovial fibroblasts clearly supports the hypothesis that SN is involved in the synovial tissue inflammation in both diseases.
Gene_expression (expression) of SGII mRNA in fibroblasts
14) Confidence 0.40 Published 2000 Journal J. Rheumatol. Section Body Doc Link 11036828 Disease Relevance 0.17 Pain Relevance 0
Expression of the precursor of secretoneurin, secretogranin II, in the synovium of patients with rheumatoid arthritis and osteoarthritis.
Gene_expression (Expression) of secretoneurin in synovium associated with neuropeptide, rheumatoid arthritis and osteoarthritis
15) Confidence 0.40 Published 2000 Journal J. Rheumatol. Section Title Doc Link 11036828 Disease Relevance 0.37 Pain Relevance 0.46
In this study we examined the possible participation of a novel peptide, secretoneurin (a cleavage product of secretogranin II), in regulation of sympathetic outflow to head and neck by using a retrograde labelling-technique combined with immunohistochemistry.
Gene_expression (product) of secretoneurin in neck
16) Confidence 0.16 Published 1995 Journal J. Chem. Neuroanat. Section Abstract Doc Link 8527038 Disease Relevance 0.09 Pain Relevance 0.37
Merkel cell carcinomas also label for neuron specific enolase (virtually all), chromogranin B (100%), chromogranin A (72%), secretoneurin (22%), and synaptophysin (39%) [5,9].
Gene_expression (label) of secretoneurin in neuron associated with carcinoma
17) Confidence 0.06 Published 2004 Journal Cytojournal Section Body Doc Link PMC535548 Disease Relevance 1.93 Pain Relevance 0

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