INT48978

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 41
Total Number 41
Disease Relevance 11.94
Pain Relevance 9.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
neurons 2
lung 2
spinal cord 1
spinal cord neurons 1
brainstem 1
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 7 100.00 Very High Very High Very High
antagonist 25 99.80 Very High Very High Very High
Spinal cord 38 99.52 Very High Very High Very High
agonist 10 99.52 Very High Very High Very High
amygdala 3 99.42 Very High Very High Very High
cINOD 8 99.40 Very High Very High Very High
tetrodotoxin 24 99.04 Very High Very High Very High
Acupuncture 10 98.64 Very High Very High Very High
antidepressant 8 98.52 Very High Very High Very High
Glutamate 11 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 268 100.00 Very High Very High Very High
Necrosis 7 100.00 Very High Very High Very High
Repression 1 100.00 Very High Very High Very High
Disease 102 99.72 Very High Very High Very High
Adenocarcinoma 145 99.64 Very High Very High Very High
Squamous Cell Carcinoma 122 99.36 Very High Very High Very High
INFLAMMATION 53 98.68 Very High Very High Very High
Glioma 5 98.58 Very High Very High Very High
Hypoxia 7 98.42 Very High Very High Very High
Stress 26 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Pretreatment and early post-treatment groups showed suppression of c-Fos activity compared to the vehicle (P <0.01).
Negative_regulation (suppression) of c-Fos
1) Confidence 0.57 Published 2001 Journal Can J Anaesth Section Body Doc Link 11698319 Disease Relevance 0 Pain Relevance 0
The addition of tetrodotoxin, nifedipine, or delta-hexachlorocyclohexane produced a significant decrease in c-fos basal values.
Negative_regulation (decrease) of c-fos associated with tetrodotoxin
2) Confidence 0.57 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7534335 Disease Relevance 0 Pain Relevance 0.18
All antidepressants increased c-fos mRNA in the central amygdala, as previously shown, while c-fos was also increased in the anterior insular cortex and significantly decreased within the septum.
Negative_regulation (decreased) of c-fos in amygdala associated with antidepressant and amygdala
3) Confidence 0.57 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15812568 Disease Relevance 0 Pain Relevance 0.56
Overexpression of ICER in cultured spinal cord neurons results in the repression of the c-fos and c-jun promoters induced by forskolin and glutamate.
Negative_regulation (repression) of c-fos in spinal cord neurons associated with glutamate, repression and spinal cord
4) Confidence 0.57 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9517483 Disease Relevance 0.25 Pain Relevance 0.47
Some studies demonstrated that gefitinib blocks selectively EGFR tyrosine-kinase (if compared with tyrosine-kinases of different receptors) and that it does not inhibit serine-threonine-kinases.19 Its activity determines an upregulation of a cell cycle inhibitor (p27) and a downregulation of a transcription factor (c-fos), resulting in arresting the cell cycle in G1 phase.20 EGFR works through two different downstream signaling pathways: MAP kinase cascade, that activates different genes linked to cell proliferation and survival, and PI3K-AKT cascade, in which phosphorylated AKT (p-AKT) inactivates proapoptotic proteins.
Negative_regulation (downregulation) of c-fos
5) Confidence 0.42 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880339 Disease Relevance 0.39 Pain Relevance 0
A similar line of reasoning can be followed for other options, for instance a leftward shift in the case of reduced levels of c-fos protein (not illustrated)
Negative_regulation (reduced) of c-fos
6) Confidence 0.42 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.04
In addition, pretreatment injection showed a greater suppression of c-Fos activity in the deep (14.6% of control) compared to the superficial laminae (32.7% of control; P <0.01), whereas the early post-treatment group showed a universal decrease in c-Fos activity (49.2% of control in laminae I and II, 50.4% of control in laminae III and IV and 51.8% of control in laminae V and VI).
Negative_regulation (decrease) of c-Fos
7) Confidence 0.42 Published 2001 Journal Can J Anaesth Section Body Doc Link 11698319 Disease Relevance 0 Pain Relevance 0
In addition, pretreatment injection showed a greater suppression of c-Fos activity in the deep (14.6% of control) compared to the superficial laminae (32.7% of control; P <0.01), whereas the early post-treatment group showed a universal decrease in c-Fos activity (49.2% of control in laminae I and II, 50.4% of control in laminae III and IV and 51.8% of control in laminae V and VI).
Negative_regulation (suppression) of c-Fos
8) Confidence 0.42 Published 2001 Journal Can J Anaesth Section Body Doc Link 11698319 Disease Relevance 0 Pain Relevance 0
Therefore, both excitation and inhibition are likely to become affected in the IC by lesions to the descending projection, leading to, at least, a partial activity block (Clarkson et al., 2010a) which is seen at this time post-lesion in continuing c-Fos down-regulation.
Negative_regulation (down-regulation) of c-Fos
9) Confidence 0.42 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0.09
Naloxone reversed the action of fentanyl on c-Fos activity.
Negative_regulation (reversed) of c-Fos
10) Confidence 0.42 Published 2001 Journal Can J Anaesth Section Body Doc Link 11698319 Disease Relevance 0 Pain Relevance 0
In separate experiments using antagonists that distinguish among members of the D(2) class of receptors, amphetamine-stimulated Fos and motor behavior were attenuated dose-dependently by the selective D(2) antagonist L-741,626, but not by the selective D(3) antagonist U99194A or the D(4)-selective antagonist L-745,870.
Negative_regulation (attenuated) of Fos associated with antagonist
11) Confidence 0.42 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10964971 Disease Relevance 0 Pain Relevance 1.04
4, Table 1) the average number of c-Fos Ir nuclei was 155326?
Negative_regulation (number) of c-Fos
12) Confidence 0.41 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0
DADLE acted against this effect of METH at least in part by attenuating the mRNA expressions of a tumor necrosis factor p53 and an immediate early gene c-fos.
Negative_regulation (attenuating) of c-fos associated with necrosis and cancer
13) Confidence 0.41 Published 2000 Journal J. Biomed. Sci. Section Abstract Doc Link 10810237 Disease Relevance 0.47 Pain Relevance 0.56
The present study was to trace the neuronal pathway in the spinal cord and brainstem following noxious stimulation and acupuncture plus noxious stimulation by using immunohistochemical technique to detect the expression of c-fos like protein.
Negative_regulation (detect) of c-fos in spinal cord associated with medulla, acupuncture and spinal cord
14) Confidence 0.41 Published 1995 Journal Acupunct Electrother Res Section Abstract Doc Link 8686569 Disease Relevance 0.06 Pain Relevance 0.51
The nitric oxide synthase (NOS) inhibitor L-NAME (5 and 50 mg/kg) reduced capsaicin-induced c-fos LI dose dependently (reduction by 13% and 59%).
Negative_regulation (reduced) of c-fos associated with qutenza
15) Confidence 0.41 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15689199 Disease Relevance 0.17 Pain Relevance 0.86
Fifteen days after cortical lesion, there is a further significant decrease of c-Fos immunoreactivity in both ICs after sound stimulation (Figures 4A and 6A).
Negative_regulation (decrease) of c-Fos
16) Confidence 0.41 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0
day after the AC lesion there was a slight decrease in c-Fos Ir particle number and density in all IC subdivisions (Figure 3C).
Negative_regulation (decrease) of c-Fos
17) Confidence 0.41 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0
Treatment of cells with tetrodotoxin before administration of the convulsant agents lowered c-fos staining below basal levels.
Negative_regulation (lowered) of c-fos associated with tetrodotoxin
18) Confidence 0.41 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7534335 Disease Relevance 0 Pain Relevance 0.21
FOS and ACEi inhibitors are widely used for the treatment of IgAN and are usually well tolerated.
Negative_regulation (inhibitors) of FOS
19) Confidence 0.32 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC415550 Disease Relevance 0.28 Pain Relevance 0.08
The proto-oncogenes FOS and JUNB, which are both overexpressed in primary tumors, are consistently downregulated in all metastatic samples.


Negative_regulation (downregulated) of FOS associated with cancer
20) Confidence 0.31 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.48 Pain Relevance 0

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