INT48979

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1993
Last Reported 2010
Negated 9
Speculated 7
Reported most in Abstract
Documents 52
Total Number 59
Disease Relevance 14.40
Pain Relevance 25.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
spinal 24
neurons 10
spinal cord 6
nucleus 6
brain 4
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 135 100.00 Very High Very High Very High
Pain 104 100.00 Very High Very High Very High
antagonist 70 100.00 Very High Very High Very High
Inflammation 62 100.00 Very High Very High Very High
Morphine 28 100.00 Very High Very High Very High
Enkephalin 28 100.00 Very High Very High Very High
Hyperalgesia 19 100.00 Very High Very High Very High
Pain threshold 19 100.00 Very High Very High Very High
Cholecystokinin 18 100.00 Very High Very High Very High
opioid receptor 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 107 100.00 Very High Very High Very High
INFLAMMATION 68 100.00 Very High Very High Very High
Hyperalgesia 19 100.00 Very High Very High Very High
Adhesions 1 100.00 Very High Very High Very High
Neuropathic Pain 31 99.74 Very High Very High Very High
Infection 50 99.66 Very High Very High Very High
Arthritis 3 99.54 Very High Very High Very High
Stress 25 99.36 Very High Very High Very High
Urological Neuroanatomy 150 99.12 Very High Very High Very High
Necrosis 1 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of inflammation on Fos expression in the ferret trigeminal nucleus.
Regulation (effect) of Gene_expression (expression) of Fos in nucleus associated with inflammation
1) Confidence 0.61 Published 2007 Journal Eur. J. Oral Sci. Section Title Doc Link 17305715 Disease Relevance 0.32 Pain Relevance 0.24
Overall, increased expression of c-fos, Egr1 and Camk1g in the present study are most likely regulated by pyrethroid-induced changes in the neuronal firing patterns of cortical neurons.
Regulation (regulated) of Gene_expression (expression) of c-fos in neurons
2) Confidence 0.60 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.13 Pain Relevance 0.16
Although positive modulators for the GABA(A) receptor (20 mg/kg 3alpha-hydroxy-5alpha-pregnan-20-one and 10-30 mg/kg chlordiazepoxide) and opioid receptor (10 mg/kg morphine) produced significant elevations, agonists for alpha(2)-adrenoceptors (clonidine) and dopamine receptors (apomorphine) had no effect on Edinger-Westphal c-Fos expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of c-Fos associated with gaba, dopamine receptor, agonist, opioid receptor, clonidine and morphine
3) Confidence 0.60 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130710 Disease Relevance 0.08 Pain Relevance 1.11
The modulation of CD-induced c-fos expression exclusively in the NTS by granisetron points to a role of 5-HT(3) receptor antagonists in the modulation of vago-vagal sensomotoric reflexes rather than an influence on forebrain nuclei involved in nociception.
Regulation (modulation) of Gene_expression (expression) of c-fos in forebrain associated with nociception and antagonist
4) Confidence 0.60 Published 2003 Journal Brain Res. Section Abstract Doc Link 12618348 Disease Relevance 0.26 Pain Relevance 0.47
Pretreatment with granisetron significantly reduced the number of c-FLI-positive cells/section in the NTS by 40%, but had no significant effect on the CD-induced c-fos expression in other brain areas.
Neg (no) Regulation (effect) of Gene_expression (expression) of c-fos in brain
5) Confidence 0.60 Published 2003 Journal Brain Res. Section Abstract Doc Link 12618348 Disease Relevance 0.27 Pain Relevance 0.75
We suggest that alterations in c-fos expression patterns in striatofugal circuits following morphine administration may be involved in drug-experience-dependent plasticity.
Regulation (alterations) of Gene_expression (expression) of c-fos associated with morphine
6) Confidence 0.60 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15138436 Disease Relevance 0 Pain Relevance 0.64
Although acute antidepressant administration altered c-fos expression in a number of brain regions, Egr-1 expression was only significantly altered in the central amygdala, suggesting that Egr-1 may not be as useful a marker to investigate acute antidepressant treatment.
Regulation (altered) of Gene_expression (expression) of c-fos in amygdala associated with antidepressant and amygdala
7) Confidence 0.60 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15812568 Disease Relevance 0 Pain Relevance 0.55
Comparison of alterations in c-fos and Egr-1 (zif268) expression throughout the rat brain following acute administration of different classes of antidepressant compounds.
Regulation (alterations) of Gene_expression (expression) of c-fos in brain associated with antidepressant
8) Confidence 0.60 Published 2005 Journal Neuropsychopharmacology Section Title Doc Link 15812568 Disease Relevance 0 Pain Relevance 0.40
In the present study, we examined the influence of c-Fos expression in the amygdala in acquisition of conditioned place aversion (CPA) induced by naloxone-precipitated withdrawal from a single morphine exposure 24 h earlier.
Spec (examined) Regulation (influence) of Gene_expression (expression) of c-Fos in CPA associated with narcan, withdrawal, amygdala and morphine
9) Confidence 0.60 Published 2008 Journal Yakugaku Zasshi Section Abstract Doc Link 18311059 Disease Relevance 0.17 Pain Relevance 1.12
Corticotropin-releasing hormone (CRH) has a critical role in most cases, but the changes in c-fos and CRH gene expression in the PVN also reveal differences among drugs.
Regulation (changes) of Gene_expression (expression) of c-fos in PVN
10) Confidence 0.60 Published 2010 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 20537734 Disease Relevance 0 Pain Relevance 0.34
However, this explanation seems unsatisfactory as the study by Totenkopf et al. (2002a) also tested c-fos expression after 2 weeks of abstinence and found no sensitization of c-fos expression in the nucleus accumbens core.
Neg (no) Regulation (sensitization) of Gene_expression (expression) of c-fos in nucleus accumbens associated with nucleus accumbens
11) Confidence 0.60 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.28
The effects of RB101, a mixed inhibitor of enkephalin-catabolizing enzymes, on carrageenin-induced spinal c-Fos expression are completely blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist.
Regulation (effects) of Gene_expression (expression) of c-Fos in spinal associated with antagonist, opioid receptor and enkephalin
12) Confidence 0.60 Published 1999 Journal Brain Res. Section Title Doc Link 10407116 Disease Relevance 0 Pain Relevance 0.48
Regulation of c-fos expression by convulsants and hexachlorocyclohexane isomers in primary cultures of cortical neurons.
Regulation (Regulation) of Gene_expression (expression) of c-fos in neurons
13) Confidence 0.60 Published 1995 Journal J. Neurochem. Section Title Doc Link 7534335 Disease Relevance 0 Pain Relevance 0.16
In conclusion, these results clearly demonstrate that the effects of morphine on noxiously-evoked spinal c-Fos expression are essentially mediated via mu-opioid receptors.
Regulation (effects) of Gene_expression (expression) of c-Fos in spinal associated with mu opioid receptor and morphine
14) Confidence 0.60 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891291 Disease Relevance 0 Pain Relevance 0.48
It is probably safe to say that the regulation of c-fos expression by drug treatment and other stimulus paradigms has biological specificity and mechanistic significance.
Regulation (regulation) of Gene_expression (expression) of c-fos
15) Confidence 0.60 Published 1993 Journal NIDA Res. Monogr. Section Abstract Doc Link 8341366 Disease Relevance 0 Pain Relevance 0
The effects of morphine on carrageenin-induced spinal c-Fos expression are completely blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist.
Regulation (effects) of Gene_expression (expression) of c-Fos in spinal associated with antagonist, opioid receptor and morphine
16) Confidence 0.60 Published 1996 Journal Brain Res. Section Title Doc Link 8891291 Disease Relevance 0 Pain Relevance 0.49
METHODS: The effects of morphine, (+)-HA966 and coadministration of morphine and (+)-HA966 on spinal c-Fos expression in segments L4-L5 of the spinal cord and peripheral edema, induced at 1.5 h and 3 h after intraplantar carrageenin (6 mg/150 microliters) were studied.
Regulation (effects) of Gene_expression (expression) of c-Fos in spinal
17) Confidence 0.60 Published 1996 Journal Anesthesiology Section Body Doc Link 8694361 Disease Relevance 0 Pain Relevance 0
It is important to note that coadministered RB101 and devazepide did not influence spinal c-Fos expression.
Regulation (influence) of Gene_expression (expression) of c-Fos in spinal
18) Confidence 0.60 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9103499 Disease Relevance 0.09 Pain Relevance 0.79
[Effect of morphine on pain threshold and C-fos expression induced by substance P].
Regulation (Effect) of Gene_expression (expression) of C-fos associated with pain threshold, substance p and morphine
19) Confidence 0.60 Published 1996 Journal Zhen Ci Yan Jiu Section Title Doc Link 9387360 Disease Relevance 0.55 Pain Relevance 0.91
Primary cortical cultures were used to study the effects of four convulsants on c-fos expression.
Regulation (effects) of Gene_expression (expression) of c-fos
20) Confidence 0.60 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7534335 Disease Relevance 0 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox