INT48980

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.07
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
neuronal 2
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 19 99.88 Very High Very High Very High
Morphine 11 99.00 Very High Very High Very High
tetrodotoxin 3 97.92 Very High Very High Very High
Neuropeptide 10 93.52 High High
cytokine 64 93.40 High High
Dynorphin 4 93.12 High High
Inflammation 144 93.00 High High
Enkephalin 9 92.40 High High
gABA 3 85.48 High High
Hippocampus 16 84.92 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 14 100.00 Very High Very High Very High
Carcinoma 1 99.02 Very High Very High Very High
Apoptosis 167 93.76 High High
INFLAMMATION 171 93.00 High High
Convulsion 2 86.36 High High
Injury 138 84.44 Quite High
Renal Disease 6 83.40 Quite High
Liver Disease 129 82.84 Quite High
Keloid Scars 5 82.16 Quite High
Fibrosis 111 72.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 15 min following PTZ injection, only transcription for c-fos was increased.
Positive_regulation (increased) of Transcription (transcription) of c-fos
1) Confidence 0.67 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170346 Disease Relevance 0.16 Pain Relevance 0.51
DREAM (calsenilin/KChIP3) is an EF-hand calcium-binding protein that binds to specific DNA sequences and regulates Ca2+-induced transcription of prodynorphin and c-fos genes.
Positive_regulation (-) of Transcription (transcription) of c-fos
2) Confidence 0.67 Published 2008 Journal Biochemistry Section Abstract Doc Link 18201103 Disease Relevance 0 Pain Relevance 0
days after cortical ablation, the number of c-Fos immunoreactive neuronal nuclei in the IC tends to increase relative to shorter post-lesion times (1 and 15?
Positive_regulation (increase) of Transcription (nuclei) of c-Fos in neuronal
3) Confidence 0.49 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0.08
Morphine at concentrations of 10(-12) M to 10(-10) M also modulated mRNA expression of early growth related genes (c-fos, c-jun and c-myc).
Positive_regulation (modulated) of Transcription (expression) of c-fos associated with morphine
4) Confidence 0.49 Published 1998 Journal Kidney Int. Section Abstract Doc Link 9461094 Disease Relevance 0.49 Pain Relevance 0.76
Lindane (gamma-hexachlorocyclohexane), Bay K 8644, pentylenetetrazole, and picrotoxinin produced a significant increase in c-fos immunoreactivity and in c-fos mRNA expression.
Positive_regulation (increase) of Transcription (expression) of c-fos
5) Confidence 0.45 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7534335 Disease Relevance 0 Pain Relevance 0.19
This motivational state was associated with increased transcription of the activity-regulated genes homer1a, arc, zif268, ngfi-b and c-fos in corticolimbic, thalamic and hypothalamic areas and of proenkephalin within striatal regions.
Positive_regulation (increased) of Transcription (transcription) of c-fos associated with aids-related complex
6) Confidence 0.45 Published 2007 Journal BMC Biol Section Abstract Doc Link PMC1868707 Disease Relevance 0.10 Pain Relevance 0.06
The response showed a similar, restricted repertoire in A498 carcinoma cells after three hours (Figure 3C). r-Ceramide upregulated TRAM, Fos and Jun transcription (10.2-, 2.2- and 2.4-fold, respectively).
Positive_regulation (upregulated) of Transcription (transcription) of Fos associated with carcinoma
7) Confidence 0.09 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.10 Pain Relevance 0
Indeed, as for TNF or other chemokines such as IL-8 and RANTES, MCP-1 depends on the activation of the redox sensitive transcription factors AP-1 and NF-?
Positive_regulation (factors) of Transcription (transcription) of AP-1 associated with chemokine
8) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.73 Pain Relevance 0.24
Indeed, as for TNF or other chemokines such as IL-8 and RANTES, MCP-1 depends on the activation of the redox sensitive transcription factors AP-1 and NF-?
Positive_regulation (as) of Transcription (transcription) of AP-1 associated with chemokine
9) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.75 Pain Relevance 0.25
Indeed, as for TNF or other chemokines such as IL-8 and RANTES, MCP-1 depends on the activation of the redox sensitive transcription factors AP-1 and NF-?
Positive_regulation (activation) of Transcription (transcription) of AP-1 associated with chemokine
10) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.74 Pain Relevance 0.25

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