INT49

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2011
Negated 3
Speculated 1
Reported most in Abstract
Documents 129
Total Number 130
Disease Relevance 37.48
Pain Relevance 35.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
plasma 65
blood 10
kidney 3
heart 3
face 3
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 178 100.00 Very High Very High Very High
Catecholamine 24 100.00 Very High Very High Very High
Serotonin 17 100.00 Very High Very High Very High
analgesia 4 99.98 Very High Very High Very High
noradrenaline 10 99.90 Very High Very High Very High
fluoxetine 7 99.84 Very High Very High Very High
anesthesia 68 99.82 Very High Very High Very High
agonist 29 99.78 Very High Very High Very High
epidural 4 99.78 Very High Very High Very High
aspirin 28 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 67 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 49 100.00 Very High Very High Very High
Heart Rate Under Development 22 100.00 Very High Very High Very High
Cv Unclassified Under Development 11 100.00 Very High Very High Very High
Bartter Syndrome 2 99.96 Very High Very High Very High
Injury 3 99.92 Very High Very High Very High
Hypoaldosteronism 1 99.92 Very High Very High Very High
Hypotension 72 99.84 Very High Very High Very High
Hypertension 213 99.80 Very High Very High Very High
Natriuresis 40 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the ninth week plasma renin activity decreased and, at week 45, became significantly lower in hypertensive than in normotensive rats. 4.
Negative_regulation (decreased) of plasma renin in plasma associated with hypertension
1) Confidence 0.59 Published 1976 Journal Clin Sci Mol Med Section Abstract Doc Link 1253523 Disease Relevance 0.92 Pain Relevance 0.09
Instead, suppression of plasma renin activity was demonstrable after re-establishment of control blood pressure.
Negative_regulation (suppression) of plasma renin in plasma
2) Confidence 0.59 Published 1979 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 572749 Disease Relevance 0.18 Pain Relevance 0.13
During 3% anaesthesia, plasma renin activity was markedly increased in the methyldopa group and decreased in the propranolol group.
Negative_regulation (decreased) of renin in plasma
3) Confidence 0.59 Published 1978 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 636807 Disease Relevance 0.56 Pain Relevance 0.51
Previous studies have shown that increased sodium chloride in drinking water failed to suppress serum renin activity (SRA) in the etheranesthetized rat.
Neg (failed) Negative_regulation (suppress) of serum renin
4) Confidence 0.59 Published 1975 Journal Endocrinology Section Abstract Doc Link 1204570 Disease Relevance 0 Pain Relevance 0.23
Both agents caused a marked, dose-related suppression of plasma renin activity.
Negative_regulation (suppression) of renin in plasma
5) Confidence 0.59 Published 1978 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 565192 Disease Relevance 0.27 Pain Relevance 0.56
It is suggested that this may contribute to the suppression of plasma renin levels observed in vivo following administration of this drug.
Negative_regulation (suppression) of plasma renin in plasma
6) Confidence 0.59 Published 1975 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1236608 Disease Relevance 0 Pain Relevance 0.51
Pretreatment with the blocker of the uptake of norepinephrine, desipramine did not prevent the initial (30 min) effect but completely prevented the delayed (4 hr) effect of fenfluramine on plasma renin activity.
Negative_regulation (prevented) of renin in plasma associated with desipramine
7) Confidence 0.59 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 3160963 Disease Relevance 0 Pain Relevance 0.28
These results suggest that the initial effect of fenfluramine is mediated via a serotonergic mechanism while the delayed, but long-lasting suppression of plasma renin activity, is mediated via a noradrenergic mechanism.
Negative_regulation (suppression) of renin in plasma
8) Confidence 0.59 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 3160963 Disease Relevance 0 Pain Relevance 0.25
Administration of DL-fenfluramine to male rats caused an initial rise, followed by a sustained decrease in plasma renin activity.
Negative_regulation (decrease) of renin in plasma
9) Confidence 0.59 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 3160963 Disease Relevance 0 Pain Relevance 0.19
Phentolamine blocked the decrease in renin caused by clonidine in ganglion-blocked rats.
Negative_regulation (decrease) of renin in ganglion associated with ganglion cysts and clonidine
10) Confidence 0.59 Published 1976 Journal Circ. Res. Section Abstract Doc Link 5201 Disease Relevance 0.17 Pain Relevance 0.75
Renal cortical renin was elevated above control in the previously clipped left kidneys and suppressed below control in the right kidneys; on the average, there was a 30-fold difference in renins of the two kidneys.
Negative_regulation (suppressed) of renin
11) Confidence 0.59 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6379148 Disease Relevance 0 Pain Relevance 0.12
It is suggested that the renin-angiotensin system is suppressed in SHR as a compensatory reaction against blood pressure elevation.
Negative_regulation (suppressed) of renin-angiotensin in blood
12) Confidence 0.58 Published 1976 Journal Am. J. Physiol. Section Abstract Doc Link 984214 Disease Relevance 0.23 Pain Relevance 0.09
The effects of renin inhibition were also tested under conditions where the renin-angiotensin system was stimulated.
Negative_regulation (inhibition) of renin
13) Confidence 0.58 Published 1989 Journal Hypertension Section Abstract Doc Link 2661429 Disease Relevance 0.32 Pain Relevance 0
Plasma renin activity was decreased below detectable limits, but plasma angiotensin II concentrations were not reduced.
Negative_regulation (decreased) of Plasma renin in Plasma
14) Confidence 0.58 Published 1989 Journal Hypertension Section Abstract Doc Link 2661429 Disease Relevance 0.33 Pain Relevance 0
In sodium-replete rats the infusion of the renin inhibitor CP71362 (100 micrograms/kg/min) decreased blood pressure by 13 +/- 1 mm Hg (p less than 0.0001), reduced plasma renin activity to undetectable levels, but did not lower plasma angiotensin II.
Negative_regulation (reduced) of plasma renin in plasma associated with pressure volume 2 under development
15) Confidence 0.58 Published 1989 Journal Hypertension Section Abstract Doc Link 2661429 Disease Relevance 0.25 Pain Relevance 0
In rats treated chronically with enalapril (30 mg/kg/day), CP71362 decreased blood pressure by an additional 5 +/- 2 mm Hg (p less than 0.025) and reduced plasma renin activity and angiotensin II concentrations to undetectable levels.
Negative_regulation (reduced) of plasma renin in plasma associated with pressure volume 2 under development
16) Confidence 0.58 Published 1989 Journal Hypertension Section Abstract Doc Link 2661429 Disease Relevance 0.27 Pain Relevance 0
Conscious, adult, water-deprived Brattleboro rats treated neonatally with capsaicin or vehicle showed similar hypotensive responses to sequential inhibition of the renin-angiotensin system (with captopril) and antagonism of ganglionic transmission (with pentolinium).
Negative_regulation (inhibition) of renin-angiotensin associated with qutenza and hypotension
17) Confidence 0.58 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3513052 Disease Relevance 0.24 Pain Relevance 0.38
The levels of active, inactive, and total renin (trypsin treatment) were measured in rat plasma before and after in vivo stimulation or suppression of active plasma renin.
Negative_regulation (suppression) of renin in plasma
18) Confidence 0.58 Published 1982 Journal Hypertension Section Abstract Doc Link 7040241 Disease Relevance 0.09 Pain Relevance 0.30
Both clonidine and guanfacine decreased plasma renin activity.
Negative_regulation (decreased) of renin in plasma associated with clonidine
19) Confidence 0.58 Published 1984 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 6386275 Disease Relevance 0.36 Pain Relevance 0.77
Intravenous injection of acebutolol into anesthetized dogs almost doubled the plasma adrenaline and noradrenaline concentrations within 5 to 15 minutes, while renin activity was reduced to approximately two-thirds of the pre-administration level.
Negative_regulation (reduced) of renin in plasma associated with noradrenaline
20) Confidence 0.58 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6368210 Disease Relevance 0.09 Pain Relevance 0.35

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