INT49001

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Context Info
Confidence 0.56
First Reported 1993
Last Reported 2010
Negated 14
Speculated 8
Reported most in Abstract
Documents 51
Total Number 59
Disease Relevance 18.28
Pain Relevance 31.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
dorsal horn 9
amygdala 2
hippocampus 2
spinal 2
dorsal 2
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 409 100.00 Very High Very High Very High
Inflammation 299 100.00 Very High Very High Very High
Glutamate receptor 247 100.00 Very High Very High Very High
Spinal cord 228 100.00 Very High Very High Very High
agonist 72 100.00 Very High Very High Very High
Nucleus accumbens 15 100.00 Very High Very High Very High
gABA 11 100.00 Very High Very High Very High
Migraine 6 100.00 Very High Very High Very High
GABA receptor 3 100.00 Very High Very High Very High
opioid receptor 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 422 100.00 Very High Very High Very High
INFLAMMATION 293 100.00 Very High Very High Very High
Migraine Disorders 6 100.00 Very High Very High Very High
Aging 458 99.84 Very High Very High Very High
Nociception 112 99.14 Very High Very High Very High
Stress 107 98.64 Very High Very High Very High
Nervous System Injury 2 98.56 Very High Very High Very High
Hypoxia 10 98.44 Very High Very High Very High
Pain 77 98.40 Very High Very High Very High
Sprains And Strains 28 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, GluR1 and NMDAR1 levels were not regulated in other regions of the mesolimbic or nigrostriatal DA pathways, including the substantia nigra.
Neg (not) Regulation (regulated) of GluR1 in substantia nigra associated with dopamine and substantia nigra
1) Confidence 0.56 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.30 Pain Relevance 1.04
Unlike cocaine, morphine, and stress, repeated treatment with other psychotropic drugs (haloperidol, raclopride, sertraline, and desipramine) that lack reinforcing or sensitizing properties did not regulate GluR1 or NMDAR1 subunit levels in the VTA.
Neg (not) Regulation (regulate) of GluR1 associated with stress, ventral tegmentum, desipramine, morphine and cocaine
2) Confidence 0.56 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.40 Pain Relevance 1.04
In addition to affecting GluA1 subunits, we observed that acute stress modulates the phosphorylation state of the GluA2 subunit in amygdala, mPFC and VH.
Regulation (affecting) of GluA1 in amygdala associated with stress, hippocampus and amygdala
3) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.52 Pain Relevance 0.59
These data suggest that GluR1 and GluR2 in the NAc shell play opposing roles in the regulation of motivated behavior.
Regulation (regulation) of GluR1 in NAc associated with nucleus accumbens
4) Confidence 0.45 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17093088 Disease Relevance 0.06 Pain Relevance 0.36
These results indicate that striatal projection neurons selectively target GluR1 subunits to their spines and dendritic shafts.
Regulation (target) of GluR1 in projection neurons associated with projection neuron
5) Confidence 0.45 Published 1998 Journal Neuroscience Section Abstract Doc Link 9483559 Disease Relevance 0 Pain Relevance 0.57
To analyze the effect of mTOR and BDNF inhibition on GluR1 expression levels, IA-trained rats received bilateral intra-CA1 infusions of rapamycin (4.3 pg/side), anti-BDNF (0.5 ug/side) or saline 15 min before training and were killed by decapitation 15 min thereafter.
Spec (analyze) Regulation (effect) of GluR1 associated with decapitation
6) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.15 Pain Relevance 0.08
When compared to the localization of tyrosine hydroxylase immunoreactivity, immunoreactivity for GluR1, GluR2/3 and NMDARI was mainly localized in the perikarya and proximal dendrites of the compacta neurons and only in a few reticulata neurons.
Regulation (immunoreactivity) of GluR1 in neurons
7) Confidence 0.40 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840222 Disease Relevance 0.22 Pain Relevance 0.54
The present study aims to investigate changes of spinal cord AMPA receptor GluR1 and its phosphorylation in inflammatory and neuropathic pain.
Spec (investigate) Regulation (changes) of GluR1 in spinal cord associated with inflammation, neuropathic pain and spinal cord
8) Confidence 0.39 Published 2008 Journal Brain Res. Section Abstract Doc Link 18289517 Disease Relevance 0.75 Pain Relevance 0.67
Compared to the transcript levels in the retina of age-matched control rats, there were no significant changes in GluR1 (Figure 2A), GluR2 (Figure 2B), GluR3 (Figure 2C), and GluR4 (Figure 2D) subunits expression, except for GluR4 at the four weeks time point, which decreased to 68±9% of the control.
Neg (no) Regulation (changes) of GluR1 in retina
9) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.64 Pain Relevance 0
The effect of diabetes on the rat retinal protein levels of GluR1, GluR2, GluR2/3, and GluR4 receptor subunits was examined by western blot analysis.
Spec (examined) Regulation (effect) of GluR1 associated with diabetes mellitus
10) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.81 Pain Relevance 0.05
In contrast, ethanol did not alter the levels of glutamate receptor subunit (GLUR) 1 or GLUR2 protein, subunits that make up the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid glutamate receptor, in the hippocampus.
Neg (not) Regulation (alter) of glutamate receptor subunit in hippocampus associated with glutamate receptor and hippocampus
11) Confidence 0.34 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133290 Disease Relevance 0 Pain Relevance 0.59
CFA-induced inflammation did not change total expression or distribution of AMPAR subunits GluR1 and GluR2 in dorsal horn but did alter their subcellular distribution.
Neg (not) Regulation (change) of GluR1 in dorsal horn associated with inflammation and dorsal horn
12) Confidence 0.34 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2628655 Disease Relevance 0.55 Pain Relevance 0.52
Thus, substance P release from non-myelinated primary afferents, and possibly nociception, may be under the functional antagonistic control of some metabotropic and ionotropic glutamate receptor subtypes.
Regulation (control) of glutamate receptor associated with nociception, glutamate receptor and substance p
13) Confidence 0.28 Published 1999 Journal Neurochem. Int. Section Abstract Doc Link 10524715 Disease Relevance 0.22 Pain Relevance 1.30
The effects of glutamate receptor agonists on neurotensin release using in vivo microdialysis.
Regulation (effects) of glutamate receptor associated with glutamate receptor and agonist
14) Confidence 0.27 Published 2001 Journal Eur. J. Pharmacol. Section Title Doc Link 11137867 Disease Relevance 0 Pain Relevance 0.42
In both amygdala regions, GluR1 and the micro-opioid receptor, the major cellular target of morphine, were only infrequently colocalized.
Regulation (target) of GluR1 in amygdala associated with opioid receptor, amygdala and morphine
15) Confidence 0.26 Published 2005 Journal Synapse Section Abstract Doc Link 16037950 Disease Relevance 0.05 Pain Relevance 0.98
The observation suggests that morphine affects this type of glutamate receptor already in the acute phase of its administration.
Regulation (affects) of glutamate receptor associated with glutamate receptor and morphine
16) Confidence 0.25 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543234 Disease Relevance 0 Pain Relevance 0.63
An unexpected observation in the current study was that CFA injection did not produce a marked change in the levels of GluR1 and GluR2 in subcellular fractions from dorsal horn at 2 h post-CFA injection.
Regulation (change) of GluR1 in dorsal horn associated with dorsal horn
17) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.25 Pain Relevance 0.41
Neither intraplantar saline nor CFA produced significant changes in the distribution or optical density of GluR1 and GluR2 immunoreactivities in L4–5 spinal dorsal horn on the ipsilateral or contralateral side at 2 h (p > 0.05) or 24 h (p > 0.05) post-saline (n = 6, 3/time point) or post-CFA (n = 6, 3/time point) injection (Fig. 3D–F).


Regulation (immunoreactivities) of GluR1 in dorsal horn associated with spinal dorsal horn
18) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.34 Pain Relevance 0.49
We next examined whether peripheral inflammatory insult affected the distribution of total GluR1 and GluR2 immunoreactivities in the spinal dorsal horn at 2 and 24 h after CFA injection.
Spec (whether) Regulation (immunoreactivities) of GluR1 in dorsal horn associated with inflammation and spinal dorsal horn
19) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.33 Pain Relevance 0.53
Consistent with previous studies [12,23,24], GluR1 immunoreactivity was distributed mainly in laminae I and II, whereas GluR2 immunoreactivity was concentrated in inner lamina II and lamina III in naïve rats (n = 3).
Regulation (immunoreactivity) of GluR1 in lamina
20) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.31 Pain Relevance 0.48

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