INT49002

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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.52
Pain Relevance 6.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Qrfp) cellular_component (Qrfp)
Anatomy Link Frequency
spinal cord 4
neurons 2
nerve 2
gracile nucleus 2
Qrfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 59 100.00 Very High Very High Very High
Calcitonin gene-related peptide 4 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Analgesic 7 99.92 Very High Very High Very High
anesthesia 1 99.92 Very High Very High Very High
qutenza 2 99.76 Very High Very High Very High
Spinal cord 7 99.44 Very High Very High Very High
Nerve growth factor 2 99.18 Very High Very High Very High
analgesia 12 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 3 98.66 Very High Very High Very High
Ganglion Cysts 4 97.88 Very High Very High Very High
Nociception 9 97.08 Very High Very High Very High
Neuropathic Pain 2 93.16 High High
Injury 3 75.44 Quite High
Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, NMDA dose dependently stimulated neuropeptide FF release, even in the presence of the Na+ channel blocker, tetrodotoxin (1 microM), suggesting that NMDA receptors involved in the release of neuropeptide FF are mainly located on nerve terminals.
Positive_regulation (stimulated) of Localization (release) of neuropeptide FF in nerve associated with tetrodotoxin, nmda receptor and neuropeptide
1) Confidence 0.61 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7535231 Disease Relevance 0 Pain Relevance 0.79
These results show that partial nerve injury to the sciatic nerve induces increases in the content of galanin, neuropeptide Y and calcitonin gene-related peptide immunoreactivities in synaptic terminals within the gracile nucleus, which suggests that there may be increased release of these neuropeptides following sensory or spontaneous stimulation of large-diameter primary afferents following partial nerve injury, perhaps one mechanism involved in neuropathic pain.
Spec (may) Positive_regulation (increased) of Localization (release) of neuropeptide in gracile nucleus associated with nervous system injury, neuropathic pain, neuropeptide, sciatic nerve and calcitonin gene-related peptide
2) Confidence 0.17 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430497 Disease Relevance 0.64 Pain Relevance 0.94
Furthermore, immunoneutralization of neuropeptide FF increases endogenous and exogenous opioid-induced analgesia.
Positive_regulation (increases) of Localization (immunoneutralization) of neuropeptide associated with neuropeptide, opioid and analgesia
3) Confidence 0.15 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9593588 Disease Relevance 0.42 Pain Relevance 2.09
Depolarization induces a Ca2+-dependent release of neuropeptide FF immunoreactivity from the spinal cord.
Positive_regulation (induces) of Localization (release) of neuropeptide in spinal cord associated with neuropeptide and spinal cord
4) Confidence 0.14 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9593588 Disease Relevance 0.29 Pain Relevance 1.31
The neuropeptide FF analogue, 1DME, enhances in vivo met-enkephalin release from the rat spinal cord.
Positive_regulation (enhances) of Localization (release) of neuropeptide FF in spinal cord associated with analgesic, neuropeptide, enkephalin and spinal cord
5) Confidence 0.10 Published 1999 Journal Neuropharmacology Section Title Doc Link 10471085 Disease Relevance 0 Pain Relevance 1.05
OBJECTIVE: To investigate the regulatory effects of nerve growth factor (NGF) on basal and capsaicin-induced release of neuropeptide substance P (SP) in primary cultured embryonic rat dorsal root ganglion (DRG) neurons.
Positive_regulation (induced) of Localization (release) of neuropeptide in neurons associated with ganglion cysts, dorsal root ganglion, qutenza, nerve growth factor, neuropeptide and substance p
6) Confidence 0.08 Published 2007 Journal Neuroscience bulletin Section Abstract Doc Link 17687396 Disease Relevance 0.17 Pain Relevance 0.41

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