INT49011

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2003
Negated 4
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.55
Pain Relevance 6.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
striatum 8
neurons 4
output neurons 2
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 28 100.00 Very High Very High Very High
Dopamine 25 100.00 Very High Very High Very High
substance P 13 100.00 Very High Very High Very High
Glutamate 9 100.00 Very High Very High Very High
Cholecystokinin 4 100.00 Very High Very High Very High
Somatostatin 3 100.00 Very High Very High Very High
Deafferentation 1 100.00 Very High Very High Very High
GABAergic 9 99.98 Very High Very High Very High
GABA receptor 4 99.76 Very High Very High Very High
gABA 27 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 6 100.00 Very High Very High Very High
Dyskinesias 2 86.40 High High
Syndrome 1 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following subchronic treatment with the GABA-A agonist muscimol, the GABA-B agonist baclofen or the GABA transaminase inhibitor gamma-vinyl GABA there were no significant changes in striatal peptide and GAD67 gene expression.
Neg (no) Regulation (changes) of Gene_expression (expression) of GAD67 gene associated with gaba and agonist
1) Confidence 0.62 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7535410 Disease Relevance 0 Pain Relevance 1.05
GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum.
Regulation (modulation) of Gene_expression (expression) of glutamic acid decarboxylase in striatum associated with dopamine receptor, gabaergic, enkephalin and substance p
2) Confidence 0.62 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7535410 Disease Relevance 0 Pain Relevance 0.81
GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum.
Regulation (modulation) of Gene_expression (expression) of GAD67 in striatum associated with dopamine receptor, gabaergic, enkephalin and substance p
3) Confidence 0.45 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7535410 Disease Relevance 0 Pain Relevance 0.81
It seems that pharmacological stimulation of GABA receptors has little effect on enkephalin, substance P or GAD67 mRNA expression in striatal output neurons.
Neg (little) Regulation (effect) of Gene_expression (expression) of GAD67 mRNA in output neurons associated with gaba receptor, enkephalin and substance p
4) Confidence 0.45 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7535410 Disease Relevance 0 Pain Relevance 1.02
The effects of neonatal 6-hydroxydopamine injections on the levels and cellular distribution of glutamate decarboxylase (GAD67), preproenkephalin and dopamine D2 receptor messenger RNAs were studied in the striatum of adult rats.
Regulation (effects) of Gene_expression (levels) of GAD67 in striatum associated with dopamine and glutamate
5) Confidence 0.45 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.28
The present results provide further evidence that GAD67 and GAD65 gene expression is differentially regulated in the two subpopulations of efferent striatal neurons.
Regulation (regulated) of Gene_expression (expression) of GAD67 in neurons
6) Confidence 0.43 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.37
Gene expression of the GAD67 and GAD65 isoforms of glutamate decarboxylase is differentially altered in subpopulations of striatal neurons in adult rats lesioned with 6-OHDA as neonates.
Regulation (altered) of Gene_expression (expression) of GAD67 in neurons associated with glutamate and enkephalin
7) Confidence 0.43 Published 1999 Journal Synapse Section Title Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.40
The purpose of the present study was to determine the role of D1-receptors in mediating some of these neurochemical events, including changes in D1- and D2-receptor binding, and the expression of preproenkephalin and glutamic acid decarboxylase mRNAs.
Regulation (changes) of Gene_expression (expression) of glutamic acid decarboxylase
8) Confidence 0.29 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9387879 Disease Relevance 0 Pain Relevance 0.13
Repeated injections of dizocilpine maleate (MK-801) do not suppress the effects of nigrostriatal dopamine deafferentation on glutamate decarboxylase (GAD67) mRNA expression in the adult rat striatum.
Neg (not) Regulation (effects) of Gene_expression (expression) of GAD67 in striatum associated with glutamate, dopamine and deafferentation
9) Confidence 0.27 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9037536 Disease Relevance 0 Pain Relevance 0.38
No change in cortical cholecystokinin (CCK), ENK, glutamic acid decarboxylase (GAD) and somatostatin (SRIF) expression, in striatal GAD, SRIF, nitric oxide synthase (NOS) and guanylate cyclase expression, and in thalamic CCK, GAD and thyrotropin-releasing hormone expression was found.
Neg (No) Regulation (change) of Gene_expression (expression) of glutamic acid decarboxylase associated with generalized anxiety disorder, somatostatin, enkephalin and cholecystokinin
10) Confidence 0.14 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12865138 Disease Relevance 0.55 Pain Relevance 0.84

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