INT49013

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.19
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Por) oxidoreductase activity (Por) endoplasmic reticulum (Por)
enzyme binding (Por)
Anatomy Link Frequency
output neurons 1
liver 1
chest 1
Por (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 3 100.00 Very High Very High Very High
Enkephalin 5 99.76 Very High Very High Very High
GABA receptor 1 99.12 Very High Very High Very High
gABA 6 94.08 High High
antagonist 3 91.52 High High
anesthesia 2 90.92 High High
GABAergic 2 75.00 Quite High
Dopamine 1 75.00 Quite High
agonist 2 74.88 Quite High
dopamine receptor 1 69.80 Quite High
Disease Link Frequency Relevance Heat
Aging 22 96.32 Very High Very High Very High
Arrhythmias 2 Under Development 88 96.04 Very High Very High Very High
Shock 32 94.80 High High
Hypoxia 2 92.24 High High
Injury 11 90.24 High High
Cancer 3 89.92 High High
Necrosis 3 89.44 High High
Emergencies 8 84.96 Quite High
Cv General 3 Under Development 1 55.88 Quite High
Hepatocellular Cancer 1 53.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It seems that pharmacological stimulation of GABA receptors has little effect on enkephalin, substance P or GAD67 mRNA expression in striatal output neurons.
Gene_expression (expression) of P or in output neurons associated with gaba receptor, enkephalin and substance p
1) Confidence 0.75 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7535410 Disease Relevance 0 Pain Relevance 1.01
It is clear, however, that such judgments and time determinants are all guesswork and that many factors, particularly the rapid provision of well performed early basic CPR, may be confounding variables.
Gene_expression (provision) of CPR
2) Confidence 0.44 Published 2004 Journal Crit Care Section Body Doc Link PMC420055 Disease Relevance 0.31 Pain Relevance 0
More recently, preliminary clinical studies have supported this evolving concept in terms of providing basic CPR procedures (i.e. chest compressions) for a short period before defibrillation in unmonitored out-of-hospital VF [8,9].
Gene_expression (procedures) of CPR in chest associated with arrhythmias 2 under development
3) Confidence 0.44 Published 2004 Journal Crit Care Section Body Doc Link PMC420055 Disease Relevance 0.60 Pain Relevance 0
The gene expression of NADPH-P450 reductase was unchanged by FFx.
Gene_expression (expression) of NADPH-P450 reductase
4) Confidence 0.37 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.42 Pain Relevance 0.07
At 72 h of FFx, liver tissues were isolated to determine the mRNA and protein expression of CYP isozymes and NADPH-P450 reductase by reverse transcription-polymerase chain reaction and Western immunoblotting, respectively.
Spec (determine) Gene_expression (expression) of NADPH-P450 reductase in liver
5) Confidence 0.37 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.51 Pain Relevance 0.09
Por's microarray expression patterns were further verified by Taqman quantitative real time PCR (qRTPCR) (Figure 6).
Gene_expression (expression) of Por
6) Confidence 0.36 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.30 Pain Relevance 0
To determine whether overexpression of NADPH cytochrome P450 reductase might act in concert with MGST1 to generate activators of sGC, we assessed GTN-induced cGMP accumulation in MGST1-overexpressing cells that had been transiently transfected with CPR.
Gene_expression (overexpression) of NADPH cytochrome P450 reductase
7) Confidence 0.05 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19428324 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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