INT49017

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2011
Negated 11
Speculated 2
Reported most in Abstract
Documents 169
Total Number 171
Disease Relevance 80.64
Pain Relevance 52.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
RAW 264 20
macrophages 19
liver 13
glial cells 10
colon 8
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1641 100.00 Very High Very High Very High
cytokine 656 100.00 Very High Very High Very High
Inflammatory response 152 100.00 Very High Very High Very High
Neuritis 8 100.00 Very High Very High Very High
Sciatic nerve 5 100.00 Very High Very High Very High
Paracetamol 313 99.98 Very High Very High Very High
agonist 174 99.98 Very High Very High Very High
dexamethasone 18 99.98 Very High Very High Very High
aspirin 67 99.84 Very High Very High Very High
COX2 40 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1977 100.00 Very High Very High Very High
Apoptosis 332 100.00 Very High Very High Very High
Periodontitis 149 100.00 Very High Very High Very High
Cancer 106 100.00 Very High Very High Very High
Periodontal Disease 69 100.00 Very High Very High Very High
Necrosis 66 100.00 Very High Very High Very High
Functional Bowel Disorder 20 100.00 Very High Very High Very High
Ulcers 17 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 8 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 51 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The initial study using rats shows that morphine-6beta-glucuronide administration (0, 1.0, 3.163, 10 mg/kg s.c.) results in a pronounced reduction in lipopolysaccharide (LPS)-induced expression of iNOS (inducible nitricoxide synthease) in spleen, lung, and liver tissue as measured by western blotting.
Negative_regulation (reduction) of Gene_expression (expression) of iNOS in liver associated with morphine
1) Confidence 0.59 Published 2001 Journal Inflammation Section Abstract Doc Link 11580103 Disease Relevance 0 Pain Relevance 0.89
Pre-treatment with ampicillin (200 mg kg(-1) day(-1), p.o.), metronidazole (200 mg kg(-1) day(-1), p.o.), or polymixin B (15 mg kg(-1) day(-1), s.c.), inhibited indomethacin-induced lesion formation, reduced microvascular leakage and prevented the expression of iNOS activity.
Negative_regulation (prevented) of Gene_expression (expression) of iNOS
2) Confidence 0.59 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11698048 Disease Relevance 0.36 Pain Relevance 0.21
Dexamethasone, salicylate and aspirin, but not indomethacin, dose dependently inhibited cytokine-stimulated NOx production and iNOS protein expression.
Negative_regulation (inhibited) of Gene_expression (expression) of iNOS protein associated with aspirin, dexamethasone and cytokine
3) Confidence 0.58 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.44 Pain Relevance 0.67
Dexamethasone decreased cytokine-induced NF-kappaB activation and iNOS mRNA expression, but neither salicylate nor aspirin affected NF-kappaB activation or iNOS mRNA expression.
Negative_regulation (decreased) of Gene_expression (expression) of iNOS mRNA associated with aspirin, dexamethasone and cytokine
4) Confidence 0.58 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.42 Pain Relevance 0.69
RESULTS: The results showed that exposure to the conditioned stimulus produced a pronounced reduction in the expression of iNOS mRNA and protein in spleen, lung, and liver tissue.
Negative_regulation (reduction) of Gene_expression (expression) of iNOS in spleen
5) Confidence 0.58 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 12457272 Disease Relevance 0 Pain Relevance 0
SR141161A also reversed the WIN 55,212-2-induced inhibition of iNOS expression.
Negative_regulation (inhibition) of Gene_expression (expression) of iNOS
6) Confidence 0.57 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11520904 Disease Relevance 0.14 Pain Relevance 0.40
In addition, GEE inhibited NO production and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) upon stimulation by lipopolysaccharide (LPS) in RAW264.7 macrophages.
Negative_regulation (inhibited) of Neg (NO) Gene_expression (production) of iNOS in macrophages
7) Confidence 0.56 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17129693 Disease Relevance 0.24 Pain Relevance 0.20
These results are not coincide with the previous studies that berberine could inhibit the expression of iNOS and IL-1?
Negative_regulation (inhibit) of Gene_expression (expression) of iNOS
8) Confidence 0.55 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1693919 Disease Relevance 0.09 Pain Relevance 0.03
As expected, ethanol fractions dose-dependently inhibited the messenger RNA expression of inducible NO synthase (iNOS).
Negative_regulation (inhibited) of Gene_expression (expression) of inducible NO synthase
9) Confidence 0.55 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688813 Disease Relevance 0.53 Pain Relevance 0.39
Furthermore, there seems a dose related correlation between the inhibition of NO production and the inhibitions of iNOS mRNA and iNOS protein expressions by WJL in RAW 264.7 cells.
Negative_regulation (inhibitions) of Gene_expression (expressions) of iNOS protein in RAW 264
10) Confidence 0.54 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0.19 Pain Relevance 0
The results suggest that WJL reduces LPS-induced NO production through the inhibition of iNOS mRNA expression, which leads to a decreased iNOS protein expression.
Negative_regulation (decreased) of Gene_expression (expression) of iNOS protein
11) Confidence 0.54 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0.44 Pain Relevance 0.04
The results showed that APW dose-dependently suppressed LPS-induced NO production in RAW 264.7 macrophages without a notable cytotoxic effect and also decreased inducible NO synthase (iNOS) protein expression.
Neg (NO) Negative_regulation (decreased) of Neg (NO) Gene_expression (expression) of iNOS in RAW 264
12) Confidence 0.52 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723341 Disease Relevance 0.48 Pain Relevance 0.23
In a subsequent study, administration of the opioid receptor antagonist, naltrexone (0.1 mg/kg) prior to the injection of morphine-6beta-glucuronide (10 mg/kg) blocks the morphine-6beta-glucuronide induced reduction of iNOS expression and plasma nitrite/nitrite levels indicating that the effect is mediated via the opioid-receptor.
Negative_regulation (reduction) of Gene_expression (expression) of iNOS in plasma associated with antagonist, opioid receptor, opioid and morphine
13) Confidence 0.51 Published 2001 Journal Inflammation Section Abstract Doc Link 11580103 Disease Relevance 0 Pain Relevance 0.99
In a subsequent study, administration of the opioid receptor antagonist, naltrexone (0.1 mg/kg) prior to the injection of heroin (1.0 mg/kg) blocked the heroin-induced reduction of iNOS expression and plasma nitrite/nitrate levels indicating that the effect is mediated via the opioid-receptor.
Negative_regulation (blocked) of Gene_expression (expression) of iNOS in plasma associated with antagonist, opioid receptor and opioid
14) Confidence 0.51 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10741899 Disease Relevance 0.14 Pain Relevance 0.20
The modulation of iNOS expression occurs via central opioid receptors as intracerebroventricular administration but not peripheral administration of N-methylnaltrexone, the quaternary form of naltrexone that does not readily cross the blood-brain barrier, reduced the expression of iNOS.
Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of iNOS in brain associated with opioid receptor and intracerebroventricular
15) Confidence 0.51 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918551 Disease Relevance 0 Pain Relevance 0.45
Naltrexone induced a pronounced dose-dependent reduction in iNOS mRNA and protein expression by splenocytes.
Negative_regulation (reduction) of Gene_expression (expression) of iNOS mRNA
16) Confidence 0.51 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918551 Disease Relevance 0 Pain Relevance 0.48
SC-560, but not rofecoxib, caused a decrease in PGE2 production, intestinal hypermotility, bacterial invasion, and iNOS expression, yet this agent neither increased iNOS activity nor provoked intestinal damage because of the recovery of PGE2 production owing to COX-2 expression.
Negative_regulation (decrease) of Gene_expression (expression) of iNOS in PGE2 associated with functional bowel disorder
17) Confidence 0.51 Published 2006 Journal Dig. Dis. Sci. Section Abstract Doc Link 16944022 Disease Relevance 0.40 Pain Relevance 0.60
Interestingly, this model also predicts another threshold shown as mth2 in Figure 7, above which (and below mth1) cytokine-induced NOS2 synthesis is suppressed.
Negative_regulation (suppressed) of Gene_expression (synthesis) of NOS2 associated with cytokine
18) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667254 Disease Relevance 0.59 Pain Relevance 0.18
The predicted mth2 is the point where expression of pro-inflammatory gene (NOS2) is completely suppressed in the presence of inflammatory cytokine (Fig. 7A).
Negative_regulation (suppressed) of Gene_expression (expression) of NOS2 associated with inflammation and cytokine
19) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667254 Disease Relevance 0.33 Pain Relevance 0.15
Selective cannabinoid CB1 receptor-mediated inhibition of inducible nitric oxide synthase protein expression in C6 rat glioma cells.
Negative_regulation (inhibition) of Gene_expression (expression) of inducible nitric oxide synthase associated with analgesic, cannabinoid and glioma
20) Confidence 0.50 Published 2001 Journal J. Neurochem. Section Title Doc Link 11520904 Disease Relevance 0.19 Pain Relevance 0.41

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