INT49020

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.97
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYR) cell proliferation (TYR) lysosome (TYR)
cytoplasm (TYR)
Anatomy Link Frequency
melanocytes 3
TYR (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 5 99.60 Very High Very High Very High
agonist 2 99.56 Very High Very High Very High
Tetrahydrobiopterin 2 99.30 Very High Very High Very High
antagonist 8 97.24 Very High Very High Very High
melanocortin 1 receptor 14 96.96 Very High Very High Very High
opioid receptor 13 95.92 Very High Very High Very High
opiate 1 91.20 High High
Inflammation 2 87.68 High High
Opioid 1 83.12 Quite High
Osteoarthritis 2 74.16 Quite High
Disease Link Frequency Relevance Heat
Microphthalmia 1 100.00 Very High Very High Very High
Wrinkles 1 99.16 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 98.72 Very High Very High Very High
Wound Healing 1 97.28 Very High Very High Very High
Skin Cancer 14 96.80 Very High Very High Very High
Pigment Disorder 2 96.52 Very High Very High Very High
INFLAMMATION 1 87.68 High High
Amelanotic Melanoma 2 84.72 Quite High
Osteoarthritis 2 74.16 Quite High
Inflammatory Bowel Disease 1 56.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tyrosinase was inhibited by the H3 agonist imetit but not by alpha-methylhistamine or the H3 antagonist thioperamide.
Negative_regulation (inhibited) of Tyrosinase associated with antagonist and agonist
1) Confidence 0.58 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.40 Pain Relevance 0.28
The H2 antagonists, famotidine and MGTI, and the imidazol(in)e receptor ligand clonidine had no effect either alone or in competition with ranitidine, whilst metiamide decreased tyrosinase activity.
Negative_regulation (decreased) of tyrosinase associated with antagonist and clonidine
2) Confidence 0.58 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.32 Pain Relevance 0.19
In contrast, treatment of White melanocytes with EIPA, cimetidine, or clonidine resulted in little inhibition of tyrosinase activity.
Negative_regulation (inhibition) of tyrosinase in melanocytes associated with clonidine
3) Confidence 0.54 Published 2004 Journal Exp. Cell Res. Section Abstract Doc Link 15265699 Disease Relevance 0 Pain Relevance 0.10
Treatment of Black melanocytes with ethyl-isopropyl amiloride (EIPA) caused a rapid dose-dependent inhibition of tyrosinase activity.
Negative_regulation (inhibition) of tyrosinase in melanocytes
4) Confidence 0.54 Published 2004 Journal Exp. Cell Res. Section Abstract Doc Link 15265699 Disease Relevance 0 Pain Relevance 0.09
In addition, as an inhibitor of tyrosinase activation, it inhibits melanin production and is useful in treatment of disorders of hyperpigmentation.
Negative_regulation (inhibitor) of tyrosinase associated with pigment disorder
5) Confidence 0.43 Published 2006 Journal J Cosmet Dermatol Section Abstract Doc Link 17716251 Disease Relevance 0.69 Pain Relevance 0.25
In this context it was reported that (6R)-l-erythro-5,6,7,8-tetrahydrobiopterin (6BH(4)) can act as an allosteric inhibitor of tyrosinase, the key enzyme in melanogenesis, and this inhibition is reversible by both alpha- and beta-MSH.
Negative_regulation (inhibitor) of tyrosinase associated with tetrahydrobiopterin
6) Confidence 0.42 Published 2005 Journal J. Endocrinol. Section Abstract Doc Link 16293777 Disease Relevance 0 Pain Relevance 0.18
Data obtained with inhibitors of EGFR Tyr kinase and membrane metalloproteases support an intermediate role of EGFR activation, involving release of endogenous membrane-bound epidermal growth factor.
Negative_regulation (inhibitors) of Tyr
7) Confidence 0.42 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11457825 Disease Relevance 0 Pain Relevance 0.52
This inhibition was not due to either direct enzyme inhibition or to a decrease in tyrosinase abundance.
Negative_regulation (decrease) of tyrosinase
8) Confidence 0.35 Published 2004 Journal Exp. Cell Res. Section Abstract Doc Link 15265699 Disease Relevance 0 Pain Relevance 0.09
Levels of mRNA and protein were measured in genes known to be up or down-regulated by agouti in the mouse, namely microphthalmia (Mitf), tyrosinase (Tyr), tyrosinase-related protein 1 (Tyrp1), dopachrome tautomerase (Dct), Mc1r, silver, initiation transcription factor 2 (Itf2) and mini chromosome maintenance protein 6 (Mcm6).
Negative_regulation (down-regulated) of tyrosinase associated with melanocortin 1 receptor and microphthalmia
9) Confidence 0.31 Published 2003 Journal Pigment Cell Res. Section Abstract Doc Link 12519127 Disease Relevance 0.46 Pain Relevance 0.34
The HIV-1 protease, SPG-40, HLA-B*2705 and Con A proteins have Trp and Tyr residues on their own inhibitory peptides; and proteinase K protein binding surface contains Trp, Phe and His residues on its binding surface.
Negative_regulation (residues) of Tyr associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0.10 Pain Relevance 0
Human epidermal melanocytes respond to purified recombinant mouse or human ASP, with a reduction in basal tyrosinase activity, and complete abrogation of the mitogenic and melanogenic effects of alpha-MSH.
Negative_regulation (reduction) of tyrosinase in melanocytes
11) Confidence 0.09 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10816645 Disease Relevance 0 Pain Relevance 0.63

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