INT49021

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Context Info
Confidence 0.68
First Reported 1994
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYR) cell proliferation (TYR) lysosome (TYR)
cytoplasm (TYR)
Anatomy Link Frequency
neural 1
TYR (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 9 94.96 High High
agonist 1 94.96 High High
antagonist 4 90.32 High High
Clonidine 1 74.00 Quite High
Disease Link Frequency Relevance Heat
Microphthalmia 2 97.56 Very High Very High Very High
Skin Cancer 4 95.72 Very High Very High Very High
Amelanotic Melanoma 1 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No change was observed in expression of gp75, neural specific octamer binding proteins, or in mRNA levels of tyrosinase, Pmel-17 and gp75 (TRP-1).
Transcription (levels) of tyrosinase in neural
1) Confidence 0.68 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.41 Pain Relevance 0.28
The microphthalmia-associated transcription factor (MITF), which belongs to the family of bHLH-LZ type transcription factors, regulates the transcription of melanogenesis-related enzyme genes such as the tyrosinase and TRP-1 genes.
Transcription (transcription) of tyrosinase associated with microphthalmia
2) Confidence 0.28 Published 2002 Journal Life Sci. Section Abstract Doc Link 12204775 Disease Relevance 0.17 Pain Relevance 0.71

General Comments

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