INT49025

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 7.15
Pain Relevance 5.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYR) cell proliferation (TYR) lysosome (TYR)
cytoplasm (TYR)
Anatomy Link Frequency
melanocytes 3
iris 1
TYR (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 4 100.00 Very High Very High Very High
antagonist 18 99.98 Very High Very High Very High
Opioid 13 99.42 Very High Very High Very High
Analgesic 6 99.02 Very High Very High Very High
Morphine 12 94.88 High High
agonist 10 94.80 High High
narcan 5 94.72 High High
melanocortin 1 receptor 15 88.68 High High
Inflammation 11 88.56 High High
opioid receptor 1 87.28 High High
Disease Link Frequency Relevance Heat
Genetic Predisposition To Disease 2 100.00 Very High Very High Very High
Microphthalmia 1 100.00 Very High Very High Very High
Chronic Hepatitis 31 99.84 Very High Very High Very High
Amelanotic Melanoma 3 99.84 Very High Very High Very High
Skin Cancer 22 99.20 Very High Very High Very High
Apoptosis 14 98.76 Very High Very High Very High
Tics 8 98.70 Very High Very High Very High
Wrinkles 1 98.64 Very High Very High Very High
Cirrhosis 57 98.00 Very High Very High Very High
Pigment Disorder 1 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nontoxic doses of the histamine H2 antagonists ranitidine, cimetidine, lamtidine and mifentidine rapidly and reversibly increased tyrosinase activity in an amelanotic human melanoma cell line (MM96L) with low constitutive activity.
Positive_regulation (increased) of tyrosinase associated with antagonist and skin cancer
1) Confidence 0.69 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.24 Pain Relevance 0.18
Overall, this work showed that certain H2 antagonists activate an unstable form of tyrosinase in amelanotic melanoma cells by a post-transcriptional mechanism dependent on protein synthesis.
Positive_regulation (activate) of tyrosinase associated with antagonist and amelanotic melanoma
2) Confidence 0.60 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.40 Pain Relevance 0.27
It is reported that there are no genetic susceptibilities for the tyrosinase gene family and interferon-?
Neg (no) Positive_regulation (susceptibilities) of tyrosinase associated with genetic predisposition to disease
3) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645903 Disease Relevance 1.04 Pain Relevance 0
In addition, as an inhibitor of tyrosinase activation, it inhibits melanin production and is useful in treatment of disorders of hyperpigmentation.
Positive_regulation (activation) of tyrosinase associated with pigment disorder
4) Confidence 0.47 Published 2006 Journal J Cosmet Dermatol Section Abstract Doc Link 17716251 Disease Relevance 0.69 Pain Relevance 0.26
Human melanocytes and pigmented human melanoma cell lines exhibited minimal levels of tyrosinase induction, which was dependent on protein synthesis but not on RNA or DNA synthesis.
Positive_regulation (induction) of tyrosinase in melanocytes associated with skin cancer
5) Confidence 0.46 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.40 Pain Relevance 0.26
The surprising change of selectivity induced by the change of chirality in peptides containing the tetrahydro-3-isoquinoline carboxylic acid (Tic) in second position, interpreted as a conformational preference induced on the Tyr-Xaa-Phe domain, can instead be attributed to the Tyr-Tic message domain.
Positive_regulation (induced) of Tyr associated with tics
6) Confidence 0.45 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8117299 Disease Relevance 0.63 Pain Relevance 0.41
The latter two analogs were more potent than the former, or alpha-MSH, in stimulating the activity of tyrosinase, thus melanogenesis, reducing apoptosis and release of hydrogen peroxide and enhancing repair of DNA photoproducts in melanocytes exposed to UV radiation (UVR).
Positive_regulation (stimulating) of tyrosinase in melanocytes associated with apoptosis
7) Confidence 0.25 Published 2006 Journal FASEB J. Section Abstract Doc Link 16723376 Disease Relevance 0.78 Pain Relevance 0.53
Those cultures failed to respond to alpha-MSH with increase in cAMP levels, tyrosinase activity, or proliferation and had an exaggerated response to the cytotoxic effect of ultraviolet (UV) radiation.
Positive_regulation (increase) of tyrosinase
8) Confidence 0.22 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12851336 Disease Relevance 0.15 Pain Relevance 0.64
A time-dependent increase in the activated (Thr and Tyr dually phosphorylated) state of ERK1 and ERK2 was also observed.
Positive_regulation (increase) of Tyr
9) Confidence 0.20 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.82
Importantly, increased melanogenesis after stimulation of the beta-MSH/cAMP/microphthalmia-associated transcription factor/tyrosinase cascade proved the functionality of this signal in melanocytes, which was attenuated in the presence of the specific MC4-R antagonist HS014.
Positive_regulation (stimulation) of tyrosinase in melanocytes associated with antagonist and microphthalmia
10) Confidence 0.20 Published 2009 Journal Endocrinology Section Abstract Doc Link 18974267 Disease Relevance 0.10 Pain Relevance 0.11
The phosphorylated form threonine/tyrosine (Thr/Tyr)-phosphorylated ERK1/2 was strongly increased in CH and LDH.
Positive_regulation (increased) of Tyr associated with chronic hepatitis
11) Confidence 0.11 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 2.14 Pain Relevance 0.04
These results demonstrate that L-TYR dose dependently potentiates the analgesic activity of opioids and are consistent with the requirement of the central conversion of L-TYR to catecholamines via TYR hydroxylase for this response.
Positive_regulation (requirement) of TYR hydroxylase associated with catecholamine, analgesic and opioid
12) Confidence 0.08 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8014863 Disease Relevance 0 Pain Relevance 1.09
These results demonstrate that L-TYR dose dependently potentiates the analgesic activity of opioids and are consistent with the requirement of the central conversion of L-TYR to catecholamines via TYR hydroxylase for this response.
Positive_regulation (requirement) of L-TYR associated with catecholamine, analgesic and opioid
13) Confidence 0.07 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8014863 Disease Relevance 0 Pain Relevance 1.09
The pathogenesis of this is not completely understood, although a
               study showed that in vitro latanoprost induces tyrosinase activity, rather than
               increasing the mitotic index in any of the human melanoma lines studied. 
Positive_regulation (induces) of tyrosinase associated with skin cancer
14) Confidence 0.07 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699817 Disease Relevance 0.29 Pain Relevance 0.06
This
               suggests that the in vivo iris pigmentation side effect of latanoprost may not
               result from increased cell division, but from elevated tyrosinase activity (Dutkiewicz et al 2000).
Positive_regulation (elevated) of tyrosinase in iris
15) Confidence 0.05 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699817 Disease Relevance 0.30 Pain Relevance 0.08

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