INT49027

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 9.81
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYRP1)
Anatomy Link Frequency
neural 4
nociceptor 2
neurons 2
urinary bladder 1
muscle 1
TYRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 33 100.00 Very High Very High Very High
Intracerebroventricular 1 99.98 Very High Very High Very High
nociceptor 62 99.92 Very High Very High Very High
qutenza 36 99.80 Very High Very High Very High
Deep tissue 2 99.00 Very High Very High Very High
Pain 107 98.44 Very High Very High Very High
Inflammation 85 97.36 Very High Very High Very High
agonist 39 96.96 Very High Very High Very High
Peripheral nervous system 1 95.24 Very High Very High Very High
Stimulus evoked pain 2 94.96 High High
Disease Link Frequency Relevance Heat
Melanoma 7 100.00 Very High Very High Very High
Nociception 20 99.84 Very High Very High Very High
Disease 160 98.80 Very High Very High Very High
Skin Cancer 37 98.64 Very High Very High Very High
Pain 110 98.44 Very High Very High Very High
Arthritis 5 97.36 Very High Very High Very High
INFLAMMATION 87 96.48 Very High Very High Very High
Cancer 11 96.20 Very High Very High Very High
Necrosis 4 95.96 Very High Very High Very High
Death 8 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: To examine the expressions of transient receptor potential (TRP) channel A1 and TRPM8 in the human urogenital organs (urinary bladder and prostate) and how these expressions change in association with bladder outlet obstruction (BOO) or benign prostatic hyperplasia (BPH).
Spec (examine) Gene_expression (expressions) of TRP in urinary bladder associated with benign prostatic hypertrophy
1) Confidence 0.75 Published 2008 Journal Urology Section Abstract Doc Link 18384850 Disease Relevance 0.19 Pain Relevance 0.07
Other nociceptors co-expressed both TRP proteins and innervated deep tissue sites (gastrocnemius muscle, distal colon; type 5, type 8) and skin (type 8).
Gene_expression (expressed) of TRP in colon associated with nociceptor and deep tissue
2) Confidence 0.75 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17287441 Disease Relevance 0 Pain Relevance 0.50
We propose that the TRP channels are functionally expressed in human synoviocytes and may play a critical role in adaptive or pathological changes in articular surfaces during arthritic inflammation.
Gene_expression (expressed) of TRP in articular associated with inflammation, trp channel and arthritis
3) Confidence 0.75 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16597917 Disease Relevance 0.36 Pain Relevance 0.32
No change was observed in expression of gp75, neural specific octamer binding proteins, or in mRNA levels of tyrosinase, Pmel-17 and gp75 (TRP-1).
Gene_expression (expression) of gp75 in neural
4) Confidence 0.75 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.41 Pain Relevance 0.27
The results had shown that the interaction between the peptides and the biomimetic systems where driven by combined electrostatic and hydrophobic effects: in ACTH(1-24) the electrostatic interaction between highly positively charged C-terminal and negatively charged surface of micelles and aggregates predominates over hydrophobic interactions involving residues in the central region of the peptide; in alpha-MSH, which presents one residual positive charge, the hydrophobic interactions are relevant to position the Trp residue in the non-polar region of the microheterogeneous systems.
Gene_expression (residue) of Trp
5) Confidence 0.65 Published 2009 Journal Biophys. Chem. Section Abstract Doc Link 19019530 Disease Relevance 0 Pain Relevance 0
The quenching of Trp fluorescence was enhanced in the presence of charged micelles, compared to the buffer solution and the accessibility of the fluorophore to the quencher was dependent on the peptide and the alkylpyridinium: in ACTH(1-21) highest collisional constants were obtained using ethylpyridinium as quencher, indicating a location of the residue in the surface of the micelle, while in alpha-MSH the best quencher was hexylpyridinium, indicating insertion of the residue into the non-polar region of the micelles.
Gene_expression (fluorescence) of Trp
6) Confidence 0.65 Published 2009 Journal Biophys. Chem. Section Abstract Doc Link 19019530 Disease Relevance 0.05 Pain Relevance 0.08
Precise regulation of the expression, localization, and function of the TRP channels is crucial for their sensory role in nociceptor terminals, particularly after inflammation, when they contribute to pain hypersensitivity by undergoing changes in translation and trafficking as well as diverse posttranslational modifications.
Gene_expression (expression) of TRP in nociceptor associated with inflammation, trp channel, nociceptor, hypersensitivity and stimulus evoked pain
7) Confidence 0.65 Published 2005 Journal Neuron Section Abstract Doc Link 15820689 Disease Relevance 0.46 Pain Relevance 0.46
Three subgroups comprise the TRP channel family; the best understood of these mediates responses to painful stimuli.
Gene_expression (comprise) of TRP associated with pain and trp channel
8) Confidence 0.65 Published 2001 Journal Nat. Rev. Neurosci. Section Abstract Doc Link 11389472 Disease Relevance 0 Pain Relevance 0.19
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.
Gene_expression (expressed) of TRP in neurons associated with nociception and qutenza
9) Confidence 0.58 Published 2003 Journal Cell Section Title Doc Link 12654248 Disease Relevance 0.17 Pain Relevance 0.41
Finally, PPT from the extensor digitorum muscle in those patients with active TrPs (mean+/-SD: 244+/-70.4 KPa) was significantly lower (P<0.001) than PPT levels of patients with no TrP in the same muscle (mean+/-SD: 370+/-83.4 KPa).
Gene_expression (levels) of TrP in muscle
10) Confidence 0.58 Published 2008 Journal Clin J Pain Section Body Doc Link 18936598 Disease Relevance 0 Pain Relevance 0
Patapoutian, ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures, Cell 112 (2003) 819-829; S.
Gene_expression (expressed) of TRP in neurons associated with nociception
11) Confidence 0.58 Published 2007 Journal Cell Calcium Section Abstract Doc Link 17499848 Disease Relevance 0.34 Pain Relevance 0.43
No change was observed in expression of gp75, neural specific octamer binding proteins, or in mRNA levels of tyrosinase, Pmel-17 and gp75 (TRP-1).
Gene_expression (levels) of gp75 in neural
12) Confidence 0.58 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.41 Pain Relevance 0.28
No change was observed in expression of gp75, neural specific octamer binding proteins, or in mRNA levels of tyrosinase, Pmel-17 and gp75 (TRP-1).
Gene_expression (expression) of gp75 in neural
13) Confidence 0.58 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.42 Pain Relevance 0.28
No change was observed in expression of gp75, neural specific octamer binding proteins, or in mRNA levels of tyrosinase, Pmel-17 and gp75 (TRP-1).
Gene_expression (levels) of TRP-1 in neural
14) Confidence 0.58 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.41 Pain Relevance 0.28
Human melanoma-specific HLA-A2 restricted CTLs have recently been shown to recognize antigens expressed by melanoma lines and normal melanocytes, including Melan-A/Mart-1, gp100, gp75, and tyrosinase.
Gene_expression (expressed) of gp75 in melanocytes associated with melanoma
15) Confidence 0.50 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9331097 Disease Relevance 0.36 Pain Relevance 0.26
TRP channel dysfunction contributes to certain human diseases.
Gene_expression (dysfunction) of TRP associated with trp channel and disease
16) Confidence 0.45 Published 2007 Journal Bull. Mem. Acad. R. Med. Belg. Section Abstract Doc Link 18075054 Disease Relevance 0.36 Pain Relevance 0.27
Transient receptor potential (TRP) channels are expressed in almost every human tissue, including the heart and vasculature.
Gene_expression (expressed) of TRP in vasculature
17) Confidence 0.40 Published 2009 Journal Circ. J. Section Abstract Doc Link 19202304 Disease Relevance 0.40 Pain Relevance 0.10
These genes encoded enzymes involved in melanogenesis, including tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), as well as melanosomal matrix proteins such as SILV and MLANA.
Gene_expression (including) of TYRP1
18) Confidence 0.37 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 1.38 Pain Relevance 0
Among the 28 identified and unique mammalian TRP (transient receptor potential) channel isoforms, at least 19 are expressed in vascular endothelial cells.
Gene_expression (expressed) of TRP in endothelial cells
19) Confidence 0.36 Published 2005 Journal Circ. Res. Section Abstract Doc Link 16254217 Disease Relevance 0.15 Pain Relevance 0.10
Conversely, intracerebroventricular Trp injection in the same species was found to increase and reduce mechanical efficiency and exercise performance in rats [35].
Gene_expression (injection) of Trp associated with intracerebroventricular
20) Confidence 0.36 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2896923 Disease Relevance 0.16 Pain Relevance 0.05

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