INT49028

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1994
Last Reported 2010
Negated 4
Speculated 6
Reported most in Abstract
Documents 102
Total Number 108
Disease Relevance 34.73
Pain Relevance 51.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
neuronal 16
neurons 8
DRG 5
brain 4
nucleus 4
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 226 100.00 Very High Very High Very High
nMDA receptor 206 100.00 Very High Very High Very High
Pain 172 100.00 Very High Very High Very High
Dorsal horn 122 100.00 Very High Very High Very High
Nerve growth factor 93 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 82 100.00 Very High Very High Very High
electroacupuncture 177 99.98 Very High Very High Very High
Central nervous system 38 99.98 Very High Very High Very High
Arthritis 9 99.84 Very High Very High Very High
cytokine 105 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 93 100.00 Very High Very High Very High
Ganglion Cysts 69 100.00 Very High Very High Very High
Death 741 99.90 Very High Very High Very High
Arthritis 46 99.84 Very High Very High Very High
Pain 185 99.64 Very High Very High Very High
Hypoxia 81 99.36 Very High Very High Very High
Nociception 64 99.34 Very High Very High Very High
INFLAMMATION 244 99.04 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 98.48 Very High Very High Very High
Convulsion 15 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased neuronal nitric oxide synthase (nNOS) activity was observed during the prodromal period of seizures in various rat brain regions following administration of GABA(A) receptor antagonist, picrotoxin (PCT).
Positive_regulation (Increased) of nNOS in brain associated with gaba, convulsion, antagonist and neuronal nitric oxide synthase
1) Confidence 0.70 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850575 Disease Relevance 0.17 Pain Relevance 0.38
Increased neuronal nitric oxide synthase (nNOS) activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic drugs.
Positive_regulation (Increased) of nNOS in neuronal associated with convulsion, antiepileptic drug and neuronal nitric oxide synthase
2) Confidence 0.70 Published 2003 Journal Brain Res. Section Title Doc Link 12850575 Disease Relevance 0.25 Pain Relevance 0.48
Because activation of NMDA receptors mediates morphine-induced c-Fos expression, we tested the hypothesis that activation of nNOS is involved in this cascade.
Positive_regulation (activation) of nNOS associated with nmda receptor and morphine
3) Confidence 0.70 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11275410 Disease Relevance 0 Pain Relevance 0.82
The increases in nNOS protein and mRNA after splanchinic ganglionectomy were significantly reversed by clonidine treatment.
Positive_regulation (increases) of nNOS protein associated with ganglionectomy and clonidine
4) Confidence 0.70 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.78
We found previously in rats that nitroglycerin (10 mg/kg s.c.) is able to increase significantly after 4 h the number of neuronal nitric oxide synthase (nNOS)-immunoreactive neurones in the cervical part of trigeminal nucleus caudalis.
Positive_regulation (increase) of nNOS in nucleus associated with neuronal nitric oxide synthase
5) Confidence 0.70 Published 2004 Journal Cephalalgia Section Abstract Doc Link 15154853 Disease Relevance 0 Pain Relevance 0.26
RNase protection assays indicated that nNOS mRNA (1) was upregulated in DRG, but not spinal cord, neurons on the injury side beginning 1 d after nerve ligation, (2) peaked (approximately 10-fold increase) at 2 d, and (3) remained elevated for at least 13 weeks.
Neg (not) Positive_regulation (upregulated) of nNOS in DRG associated with injury and spinal cord
6) Confidence 0.69 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531423 Disease Relevance 0.89 Pain Relevance 0.79
A corresponding increase in DRG nNOS protein was also observed and localized principally to small and occasionally medium-size sensory neurons.
Positive_regulation (increase) of nNOS in sensory neurons
7) Confidence 0.69 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531423 Disease Relevance 0.95 Pain Relevance 0.85
We investigated the hypothesis that hind paw injection of formalin increases the number of dorsal horn neuronal nitric oxide synthase (nNOS) containing neurons.
Spec (investigated) Positive_regulation (increases) of nNOS in paw associated with dorsal horn and neuronal nitric oxide synthase
8) Confidence 0.69 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8805130 Disease Relevance 0.09 Pain Relevance 0.54
The results suggest that PA upregulation of neuronal nitric oxide synthase and NR2B subunit expression in the spinal dorsal horn contributes to PA inhibition of hyperalgesia induced by chronic compression of dorsal root ganglia.
Positive_regulation (upregulation) of neuronal nitric oxide synthase in dorsal horn associated with hyperalgesia, spinal dorsal horn and neuronal nitric oxide synthase
9) Confidence 0.69 Published 2007 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 18000292 Disease Relevance 0.39 Pain Relevance 0.84
Nitric oxide triggers delayed anesthetic preconditioning-induced cardiac protection via activation of nuclear factor-kappaB and upregulation of inducible nitric oxide synthase.
Positive_regulation (upregulation) of nitric oxide synthase
10) Confidence 0.67 Published 2008 Journal Shock Section Title Doc Link 18708911 Disease Relevance 0.23 Pain Relevance 0.21
Unlike previous findings showing upregulation of nNOS mRNA and AVP hnRNA under somatic nociceptive states, the levels of nNOS mRNA and AVP hnRNA were unchanged in the PVN following CP-induced cystitis, visceral nociceptive stimulation.
Positive_regulation (upregulation) of nNOS mRNA in PVN associated with nociception and cystitis
11) Confidence 0.63 Published 2004 Journal Brain Res. Section Abstract Doc Link 15276878 Disease Relevance 0.67 Pain Relevance 0.04
These results suggest that both NOS I and NOS II are upregulated following intradermal capsaicin injection and that both cause NO release that contributes to the secondary hyperalgesia and allodynia following this noxious chemical stimulus.
Positive_regulation (upregulated) of NOS I associated with hyperalgesia, allodynia and qutenza
12) Confidence 0.63 Published 2001 Journal Pain Section Abstract Doc Link 11576744 Disease Relevance 0.27 Pain Relevance 0.97
Glutamate acting on NMDA receptors in the central nervous system activates the enzyme neuronal nitric oxide synthase (nNOS), resulting in nitric oxide (NO) formation (Garthwaite et al. 1988; Garthwaite and Boulton 1995).
Positive_regulation (activates) of nNOS in neuronal associated with glutamate, nmda receptor, central nervous system and neuronal nitric oxide synthase
13) Confidence 0.62 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2517108 Disease Relevance 0.30 Pain Relevance 0.47
Increased neuronal nitric oxide synthase (nNOS) activity was observed during the prodromal period of seizures in various rat brain regions following administration of GABA(A) receptor antagonist, picrotoxin (PCT).
Positive_regulation (Increased) of neuronal nitric oxide synthase in brain associated with gaba, convulsion, antagonist and neuronal nitric oxide synthase
14) Confidence 0.61 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850575 Disease Relevance 0.17 Pain Relevance 0.38
Increased neuronal nitric oxide synthase (nNOS) activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic drugs.
Positive_regulation (Increased) of neuronal nitric oxide synthase in neuronal associated with convulsion, antiepileptic drug and neuronal nitric oxide synthase
15) Confidence 0.61 Published 2003 Journal Brain Res. Section Title Doc Link 12850575 Disease Relevance 0.25 Pain Relevance 0.48
NMDA receptor-mediated increases in intracellular calcium can activate nNOS, which catalyzes the formation of the signaling molecule nitric oxide.
Positive_regulation (activate) of nNOS associated with nmda receptor
16) Confidence 0.61 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11275410 Disease Relevance 0 Pain Relevance 0.76
Induction of neuronal nitric oxide synthase by sympathetic denervation is mediated via alpha 2-adrenoceptors in the jejunal myenteric plexus.
Positive_regulation (Induction) of neuronal nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
17) Confidence 0.61 Published 2003 Journal Brain Res. Section Title Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.46
However, similar increases in DRG nNOS mRNA were observed in rats that did not develop allodynia after nerve ligation and in rats fully recovered from allodynia 3 months after the nerve ligation.
Positive_regulation (increases) of nNOS in nerve associated with allodynia
18) Confidence 0.61 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531423 Disease Relevance 0.95 Pain Relevance 0.96
Vagotomy did not increase the number of nNOS(-) growth cones in NG.
Neg (not) Positive_regulation (increase) of nNOS in growth cones associated with ganglion cysts
19) Confidence 0.60 Published 2010 Journal Neuroscience Section Abstract Doc Link 20197082 Disease Relevance 0.49 Pain Relevance 0.82
This upregulation of nNOS following formalin stimulation of the hind paw suggested that nitric oxide (NO) may play a role in the central mechanism of hyperalgesia that follows peripheral inflammation.
Positive_regulation (upregulation) of nNOS in paw associated with hyperalgesia and inflammation
20) Confidence 0.60 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8805130 Disease Relevance 0.27 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox