INT49029

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Context Info
Confidence 0.09
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 6.28
Pain Relevance 3.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Decr1) oxidoreductase activity (Decr1) nucleus (Decr1)
cytoplasm (Decr1)
Anatomy Link Frequency
neurons 2
macrophage 1
cardiomyocyte 1
spinal cord 1
dorsal horn 1
Decr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 25 99.84 Very High Very High Very High
Inflammation 111 99.82 Very High Very High Very High
cINOD 64 99.66 Very High Very High Very High
Pain 8 99.50 Very High Very High Very High
Central nervous system 11 99.08 Very High Very High Very High
Dorsal horn 26 99.04 Very High Very High Very High
Morphine 10 98.40 Very High Very High Very High
Inflammatory stimuli 20 97.36 Very High Very High Very High
Hippocampus 12 96.64 Very High Very High Very High
Neuronal nitric oxide synthase 1 94.96 High High
Disease Link Frequency Relevance Heat
Injury 34 99.98 Very High Very High Very High
INFLAMMATION 203 99.82 Very High Very High Very High
Drug Induced Neurotoxicity 57 98.76 Very High Very High Very High
Diabetes Mellitus 48 97.42 Very High Very High Very High
Urological Neuroanatomy 6 96.40 Very High Very High Very High
Nociception 5 96.36 Very High Very High Very High
Parkinson's Disease 89 95.44 Very High Very High Very High
Disease 617 95.16 Very High Very High Very High
Death 90 94.72 High High
Hyperalgesia 3 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, microglial NADPH activity is enhanced together with microglial activation and the peak of NADPH activity is only observed 48 h after administration of MPTP [42].
Positive_regulation (enhanced) of NADPH associated with parkinson's disease
1) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.46 Pain Relevance 0.22
Inflammation-induced activation of microglial NADPH oxidase and iNOS has been reported to act synergistically to kill neurons through the formation of peroxynitrite [82].
Positive_regulation (activation) of NADPH in neurons associated with inflammation
2) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.35 Pain Relevance 0.09
Activation of the NADPH oxidase occurs when the macrophage/microglial cell is exposed to inflammatory stimuli initiating the activation of multiple parallel intracellular signaling cascades.
Positive_regulation (Activation) of NADPH in microglial cell associated with inflammatory stimuli
3) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.18 Pain Relevance 0.09
The excessive production of these free radicals can damage tissue adjacent to the sites of inflammatory action; therefore, the activation of the NADPH oxidase is tightly controlled though regulated assembly of the individual oxidase subunits into a functionally active complex [34].
Positive_regulation (activation) of NADPH associated with inflammation
4) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.27 Pain Relevance 0.08
In primary astrocytes cultures, NADPH oxidase activation was induced by exposure to fA?
Positive_regulation (activation) of NADPH in astrocytes
5) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.22 Pain Relevance 0.09
Activation of NADPH oxidase, superoxide and reactive oxygen species are known to cause cardiomyocyte contractile dysfunction [20], [28], [33].
Positive_regulation (Activation) of NADPH in cardiomyocyte
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.56 Pain Relevance 0.03
In the central nervous system, Noh and Koh (2000) were able to demonstrate increased NADPH oxidase-derived (NOX2) ROS production in cortical cultures in response to zinc exposure [72].
Positive_regulation (increased) of NADPH in central nervous system associated with central nervous system
7) Confidence 0.05 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.35 Pain Relevance 0.14
stimulation, the Vav guanine nucleotide exchange factor (GEF) is a key modulator of NADPH oxidase assembly in monocytes and primary microglia (Figure 3).
Positive_regulation (modulator) of NADPH in monocytes
8) Confidence 0.05 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.07 Pain Relevance 0
While the precise role of Rac in NADPH oxidase activation is not fully understood, several lines of evidence suggest Rac acts as an adaptor molecule for p67phox [46,47], and may be actively involved in the electron transfer process itself [48,49].
Positive_regulation (activation) of NADPH
9) Confidence 0.05 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.04
These findings suggest that these kinases are involved in upstream signaling cascades responsible for activating NADPH oxidase assembly in response to fA?
Positive_regulation (activating) of NADPH
10) Confidence 0.05 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.04
Our results suggest that in addition to the pathological state that led to our observed loss of sensory neurons (and diminished NADPH-d labeling in the dorsal horn), there is a ongoing perturbation resulting in increased NADPH-d labeling in small DRG neurons from hyperglycemic animals as compared to the primary sensory somata from normoglycemic animals.
Positive_regulation (increased) of NADPH-d in dorsal horn associated with dorsal horn
11) Confidence 0.04 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1865541 Disease Relevance 0.15 Pain Relevance 0.30
-dependent activation of the NADPH oxidase, there is evidence suggesting vitamin E could potentially inhibit an A?
Positive_regulation (activation) of NADPH
12) Confidence 0.04 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.57 Pain Relevance 0.04
Small somata from the ganglia of diabetic mice exhibited lower levels of AP (13.4% decrease; P < 0.001) and CO (Fig 1A,B; 9% decrease; P < 0.001) reaction product and an increase in the density of the reaction product for NADPH-d (Fig. 1C,D; 13.2% increase; P < 0.001) in comparison to control animals.
Positive_regulation (increase) of NADPH-d in ganglia associated with diabetes mellitus
13) Confidence 0.04 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1865541 Disease Relevance 0.61 Pain Relevance 0.07
Activation of the NADPH oxidase occurs when the macrophage/microglial cell is exposed to inflammatory stimuli initiating the activation of multiple parallel intracellular signaling cascades.
Positive_regulation (Activation) of NADPH in macrophage associated with inflammatory stimuli
14) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.18 Pain Relevance 0.09
Anti-inflammatory drugs suppress injury-induced NADPH-d activity in CA1 pyramidal neurones.
Positive_regulation (induced) of NADPH-d associated with inflammation, injury and cinod
15) Confidence 0.01 Published 1994 Journal Neuroreport Section Title Doc Link 7827327 Disease Relevance 0.38 Pain Relevance 0.28
Inducibility of NADPH-diaphorase (NADPH-d) or nitric oxide synthase (NOS) has been demonstrated in pyramidal neurones of the hippocampus, but the mechanisms of this induction are not known.
Positive_regulation (Inducibility) of NADPH-d in hippocampus associated with hippocampus
16) Confidence 0.01 Published 1994 Journal Neuroreport Section Abstract Doc Link 7827327 Disease Relevance 0.32 Pain Relevance 0.24
Our data showed that the noxious visceral stimulation significantly increased NADPH-d positive neurons and that these neurons were localized in the ventrolateral areas of the PAG.
Positive_regulation (increased) of NADPH-d in neurons associated with urological neuroanatomy
17) Confidence 0.00 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630710 Disease Relevance 0.79 Pain Relevance 0.44
[Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats].
Positive_regulation (formalin-induced) of NADPH-d in spinal cord associated with pain, morphine and spinal cord
18) Confidence 0.00 Published 2000 Journal Sheng Li Xue Bao Section Title Doc Link 11956571 Disease Relevance 0 Pain Relevance 1.10
Carrageenan-produced unilateral hindpaw inflammation in the rat results in a bilateral increase in NADPH-d in spinal cord neurons.
Positive_regulation (increase) of NADPH-d in spinal cord neurons associated with inflammation and spinal cord
19) Confidence 0.00 Published 1994 Journal Brain Res. Section Abstract Doc Link 7535654 Disease Relevance 0.64 Pain Relevance 0.59

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