INT49041

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Context Info
Confidence 0.72
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 12.52
Pain Relevance 12.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
spinal cord 3
posterior 2
dorsal horn 2
hippocampal formation 1
brain 1
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 83 100.00 Very High Very High Very High
antagonist 46 100.00 Very High Very High Very High
Dorsal horn 69 99.68 Very High Very High Very High
opiate 6 99.54 Very High Very High Very High
Central nervous system 79 99.20 Very High Very High Very High
Inflammation 117 99.08 Very High Very High Very High
Pain 113 98.94 Very High Very High Very High
Spinal cord 128 98.92 Very High Very High Very High
dorsal root ganglion 12 98.12 Very High Very High Very High
Hippocampus 111 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 166 99.64 Very High Very High Very High
Ganglion Cysts 22 99.40 Very High Very High Very High
Stress 53 99.14 Very High Very High Very High
INFLAMMATION 129 99.08 Very High Very High Very High
Pain 137 98.94 Very High Very High Very High
Increased Venous Pressure Under Development 10 97.60 Very High Very High Very High
Rheumatoid Arthritis 15 97.44 Very High Very High Very High
Reprotox - General 1 4 97.28 Very High Very High Very High
Coronary Artery Disease 4 96.36 Very High Very High Very High
Cv General 3 Under Development 1 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dilute formalin injected into the rat hindpaw as a nociceptive stimulus increases neurokinin-1 receptor (NK-1R) mRNA levels in the dorsal horn of the spinal cord.
Transcription (levels) of neurokinin-1 receptor in spinal cord associated with nociception, dorsal horn and spinal cord
1) Confidence 0.72 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.17 Pain Relevance 0.20
In formalin-treated animals, the temporal pattern of peak pre-mRNA levels compared with mature mRNA indicated that chemogenic nociception either activates transcription of the NK-1R gene or decreases the rate of pre-mRNA splicing.
Transcription (transcription) of NK-1R gene associated with nociception
2) Confidence 0.72 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.29 Pain Relevance 0.22
Increased NK-1R mRNA levels could result from increased mRNA stability or an increased rate of NK-1R mRNA transcription.
Transcription (transcription) of NK-1R mRNA
3) Confidence 0.72 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.17 Pain Relevance 0.20
The amount of NK-1R protein and mRNA in the oesophageal tissue was significantly higher at both the erosion and non-erosion sites.
Transcription (amount) of NK-1R protein
4) Confidence 0.69 Published 2010 Journal Neurogastroenterol. Motil. Section Body Doc Link 20059697 Disease Relevance 0.07 Pain Relevance 0
The NK1-receptor antagonist ezlopitant decreases voluntary sucrose consumption in C57BL/6 mice
Transcription (ezlopitant) of NK1-receptor associated with antagonist
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931709 Disease Relevance 0 Pain Relevance 0.05
NK1 receptor mRNA and protein expression in the peri-implant mucosa were confirmed by reverse transcription with the polymerase chain reaction and immunoblotting.
Transcription (expression) of NK1 receptor
6) Confidence 0.68 Published 2009 Journal Cell Tissue Res. Section Abstract Doc Link 19015883 Disease Relevance 0 Pain Relevance 0.08
Dilute formalin injected into the rat hindpaw as a nociceptive stimulus increases neurokinin-1 receptor (NK-1R) mRNA levels in the dorsal horn of the spinal cord.
Transcription (levels) of NK-1R in spinal cord associated with nociception, dorsal horn and spinal cord
7) Confidence 0.63 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.17 Pain Relevance 0.20
Solution hybridization-nuclease protection assays quantified neurokinin receptor messenger RNA levels in central and peripheral tissues from normal and formalin-inflamed rats.
Transcription (levels) of neurokinin receptor
8) Confidence 0.53 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430499 Disease Relevance 0.36 Pain Relevance 0.51
Expression in small DRG neurons (diameter < 21 microm) was confirmed by in situ hybridization of isolated cells, which were demonstrated to express NK-1 receptor mRNA at a very high frequency (> 90% of small DRG neurons) and therefore were subjected to whole-cell recording.
Transcription (express) of NK-1 receptor in DRG associated with dorsal root ganglion
9) Confidence 0.46 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9749783 Disease Relevance 0.58 Pain Relevance 0.56
In situ hybridization assay results demonstrated that either pain or stress (acute or chronic treatments) reduced the levels of both NK-1 receptor and BDNF mRNAs in the cornu ammonis 1-3 sublayers of the hippocampus, suggesting a possible role of these neuromediators in processing of pain in higher brain centers.
Transcription (levels) of NK-1 receptor in brain associated with stress, pain and hippocampus
10) Confidence 0.43 Published 2006 Journal J Pain Section Abstract Doc Link 16885011 Disease Relevance 1.77 Pain Relevance 1.16
Needle manipulation was also effective in suppressing the mRNA expression of pain-related genes such as Fos, opioid receptor-like 1, tachykinin 1, tachykinin receptor 1, mu-opioid receptor and 5-hydroxytryptamine receptor 2A in the spinal cord.
Transcription (expression) of tachykinin receptor 1 in spinal cord
11) Confidence 0.42 Published 2010 Journal Neurol. Res. Section Body Doc Link 20034454 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVE: To observe the expressions of the substance P (SP) mRNA and neurokinin-1 receptor (NK-1R) in the posterior horn of the L5 - S2 spinal cord in the rat model of chronic prostatitis pain, and to investigate the changes in the activation of astrocytes and influence of SP on this activation in rat spinal cord astrocytes cultured in vitro.
Transcription (expressions) of neurokinin-1 receptor in posterior associated with pain, prostatitis, spinal cord and substance p
12) Confidence 0.42 Published 2009 Journal Zhonghua Nan Ke Xue Section Abstract Doc Link 20218316 Disease Relevance 0.34 Pain Relevance 0.57
OBJECTIVE: To observe the expressions of the substance P (SP) mRNA and neurokinin-1 receptor (NK-1R) in the posterior horn of the L5 - S2 spinal cord in the rat model of chronic prostatitis pain, and to investigate the changes in the activation of astrocytes and influence of SP on this activation in rat spinal cord astrocytes cultured in vitro.
Transcription (expressions) of NK-1R in posterior associated with pain, prostatitis, spinal cord and substance p
13) Confidence 0.42 Published 2009 Journal Zhonghua Nan Ke Xue Section Abstract Doc Link 20218316 Disease Relevance 0.34 Pain Relevance 0.58
CFA evoked robust decreases in NK-1 receptor and BDNF mRNA levels in the hippocampal formation, contrary to the prominent up-regulation seen in the spinal cord.
Transcription (levels) of NK-1 receptor in hippocampal formation associated with spinal cord
14) Confidence 0.39 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.73 Pain Relevance 0.69
Current results demonstrate that NK-1 receptor and BDNF mRNA levels are initially increased in the ipsilateral dorsal horn at 24 h and 4 days post CFA (Fig. 1), consistent with results of other studies [35,39,40].
Transcription (levels) of NK-1 receptor in dorsal horn associated with dorsal horn
15) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.54 Pain Relevance 0.76
Results of this study showed that injections of complete Freund's adjuvant (CFA) into the hind paw increased NK-1 receptor and BDNF mRNA levels in the ipsilateral dorsal horn, supporting an important role for these nociceptive mediators in the amplification of ascending pain signaling.
Transcription (levels) of NK-1 receptor in paw associated with nociception, pain and dorsal horn
16) Confidence 0.29 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2174921 Disease Relevance 0.81 Pain Relevance 0.92
However, the transcription of NK-1 receptor gene at the later phase of inflammation is probably dependent on other regulatory pathways, since no changes were observed in the dorsal horn 21 days after CFA.


Transcription (transcription) of NK-1 receptor gene in dorsal horn associated with inflammation and dorsal horn
17) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.60 Pain Relevance 0.42
The results of this study indicate that pretreatment with opiate ligands modulates the expression of tachykinin peptide and neurokinin receptor encoding mRNAs in spinal systems following a peripheral chemogenic inflammatory stimulus.
Transcription (expression) of neurokinin receptor in spinal associated with opiate and inflammatory stimuli
18) Confidence 0.28 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536308 Disease Relevance 0.33 Pain Relevance 0.71
Quantitative single-cell RT-PCR analysis showed the increased expression of mRNA for the NK1 receptor in FG-labeled TRG neurons in inflamed rats compared with that in naive rats.
Transcription (expression) of NK1 receptor in TRG associated with ganglion cysts
19) Confidence 0.23 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15625101 Disease Relevance 1.28 Pain Relevance 0.92
Subsequently hippocampal volume and specific gravity were measured and NK-1 receptor and BDNF mRNA levels quantified using ribonuclease protection assays.
Transcription (levels) of NK-1 receptor
20) Confidence 0.22 Published 2005 Journal Neuroscience Section Abstract Doc Link 15964488 Disease Relevance 1.30 Pain Relevance 0.81

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