INT49054

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 13.83
Pain Relevance 12.88

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Anatomy Mention Frequency
nucleus 6
spinal 5
spinal cord 4
neuronal 4
neurons 4


Pain Term Frequency Confidence Heat
Spinal cord 139 100.00 Very High Very High Very High
narcan 12 100.00 Very High Very High Very High
Morphine 37 99.98 Very High Very High Very High
Pain 224 99.98 Very High Very High Very High
Dorsal horn neuron 10 99.84 Very High Very High Very High
tetrodotoxin 2 99.72 Very High Very High Very High
antagonist 54 99.72 Very High Very High Very High
orphanin 2 99.48 Very High Very High Very High
cocaine 39 99.28 Very High Very High Very High
central sensitization 12 99.28 Very High Very High Very High
Disease Term Frequency Confidence Heat
Pain 255 99.98 Very High Very High Very High
Osteoporosis 14 99.60 Very High Very High Very High
Eating Disorder 16 99.24 Very High Very High Very High
Neuropathic Pain 111 99.20 Very High Very High Very High
Pressure And Volume Under Development 6 98.68 Very High Very High Very High
Nociception 125 98.04 Very High Very High Very High
INFLAMMATION 231 96.16 Very High Very High Very High
Hyperalgesia 60 96.08 Very High Very High Very High
Experimental Arthritis 9 94.20 High High
Nervous System Injury 35 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BoNT/A injections are analgesic for painful muscle contractions associated with cervical dystonia, migraine/tension headaches, and myofascial pain syndromes.23 In BoNT/A treatment of painful soft tissue syndromes, pain relief preceded the resolution of muscle contractions, suggesting that BoNTs may have antinociceptive effects independent of known effects on neuromuscular junctions.24 BoNT/A inhibited capsaicin-stimulated release of substance P from embryonic rat dorsal root ganglia neurons in culture.25 Subcutaneous BoNT/A paw injections in a formalin-induced rat model of pain reduced electrical excitations and c-fos expression in the spinal cord, and reduced edema and tissue glutamate release.26
Negative_regulation (reduced) of Gene_expression (expression) of c-fos in muscle associated with pain, pressure and volume under development, cervical cancer, qutenza, syndrome, migraine, analgesic, myofascial pain syndrome, antinociceptive, spinal cord, glutamate, tension-type headache, headache and substance p
1) Confidence 0.57 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004655 Disease Relevance 1.65 Pain Relevance 1.95
To localize the site of action of the anaesthetics, they used c-fos expression as an index of neuronal activity, and found that muscimol, propofol or pentobarbital increased c-fos expression in the ventro-lateral pre-optic nucleus, but decreased c-fos expression in the hypothalamic TMN.
Negative_regulation (decreased) of Gene_expression (expression) of c-fos in nucleus
2) Confidence 0.57 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0.06 Pain Relevance 0.17
However, c-fos expression is only transiently decreased after indirect blockade of NMDA receptors by CHA, suggesting the existence of additional spinal mechanisms [13].
Negative_regulation (decreased) of Gene_expression (expression) of c-fos in spinal associated with nmda receptor
3) Confidence 0.57 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2927688 Disease Relevance 1.18 Pain Relevance 1.29
The inhibition of c-Fos expression in the spinal cord by BV apipuncture in several nociceptive models is also reported to be a possible mechanism.
Negative_regulation (inhibition) of Gene_expression (expression) of c-Fos in spinal cord associated with nociception and spinal cord
4) Confidence 0.57 Published 2007 Journal Pharmacol. Ther. Section Abstract Doc Link 17555825 Disease Relevance 1.40 Pain Relevance 0.51
The intra-articular injection of memantine (0.2 mg) also suppressed c-Fos expression in the laminae I-II and laminae V-VI at the L3-4 spinal level and the degree of the spinal c-Fos expression was correlated with the extent of the pain-related behaviour [308].


Negative_regulation (suppressed) of in articular Gene_expression (expression) of c-Fos in spinal associated with pain
5) Confidence 0.42 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.71 Pain Relevance 0.63
This is supported by the observations that ICER attenuates c-fos mRNA expression in cultured cells [28, 55]; that increase in ICER expression after nociceptin injection coincides with decreased c-Fos protein expression [48]; and that kindling stimulus-induced c-Fos protein expression is attenuated by ICER overexpression in vivo [21].
Negative_regulation (decreased) of Gene_expression (expression) of c-Fos associated with orphanin
6) Confidence 0.42 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.30 Pain Relevance 0.13
We then evaluated the ability of JMV-431 and levocabastine to suppress formalin-induced c-fos protein expression.
Negative_regulation (suppress) of Gene_expression (expression) of c-fos
7) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.25 Pain Relevance 0.34
With resolution at the single-cell level, we also found that activation of spinal NTS2 receptors reduced formalin-induced c-fos expression in dorsal horn neurons.
Negative_regulation (reduced) of Gene_expression (expression) of c-fos in neurons associated with dorsal horn neuron
8) Confidence 0.42 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2714839 Disease Relevance 0.72 Pain Relevance 1.07
Systemic administration of d-amphetamine and cocaine causes a dose-response increase in c-fos expression in the rat cerebellum, an effect which is reduced by pretreatment with SCH23390, a D1 receptor antagonist [59].
Negative_regulation (reduced) of Gene_expression (expression) of c-fos in cerebellum associated with antagonist and cocaine
9) Confidence 0.42 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.17 Pain Relevance 0.58
The increase in c-fos expression in the superficial laminae of the spinal cord in this model was also inhibited.
Negative_regulation (inhibited) of Gene_expression (expression) of c-fos in spinal cord associated with spinal cord
10) Confidence 0.42 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.65 Pain Relevance 1.03
S4IL4 inoculation suppressed non-noxious-induced expression of c-Fos immunoreactivity in dorsal horn of spinal cord, and reversed the upregulation of spinal IL-1?
Negative_regulation (suppressed) of Gene_expression (expression) of c-Fos in dorsal horn associated with dorsal horn and spinal cord
11) Confidence 0.42 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.64 Pain Relevance 1.22
S4IL4 inoculation suppressed non-noxious-induced expression of c-Fos immunoreactivity in dorsal horn of spinal cord and reversed the upregulation of spinal IL-1?
Negative_regulation (suppressed) of Gene_expression (expression) of c-Fos in spinal associated with dorsal horn and spinal cord
12) Confidence 0.42 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1395302 Disease Relevance 1.57 Pain Relevance 1.26
The topographical distribution of c-Fos expression within the nTS was similar to that observed following i.t. administration of M. vaccae, with c-Fos expression almost entirely restricted to the SolDL region (de Vries et al., 2005), a major target of bronchopulmonary afferent vagal fibers (Kalia and Mesulam, 1980).
Negative_regulation (distribution) of Gene_expression (expression) of c-Fos
13) Confidence 0.42 Published 2007 Journal Neuroscience Section Body Doc Link PMC1868963 Disease Relevance 0.96 Pain Relevance 0.07
Figure 1B illustrates that rAAV-dnCaMKIV but not rAAV-hrGFP dramatically reduced expression of the CREB-target gene c-fos after induction of action potential (AP) bursting.
Negative_regulation (reduced) of Gene_expression (expression) of c-fos associated with action potential
14) Confidence 0.41 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.21 Pain Relevance 0.26
B pathways, thereby suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors [36].


Negative_regulation (suppressing) of Gene_expression (expression) of c-Fos in osteoclast
15) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.64 Pain Relevance 0.12
The experimental findings of the study suggested that EGCG inhibits oncostatin M-induced MCP-1/CCL2 synthesis in human osteoblastic and MG-63 cells by reducing c-Fos synthesis [31].
Negative_regulation (reducing) of Gene_expression (synthesis) of c-Fos in MG-63 associated with osteoporosis
16) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.82 Pain Relevance 0
In addition, agmatine (1 microM) co-pretreated with morphine attenuated the naloxone-precipitated increases of cAMP-responsive element binding protein and extracellular signal-regulated kinase 1/2 phosphorylations and c-Fos expression in CHO-mu/IRAS.
Negative_regulation (attenuated) of Gene_expression (expression) of c-Fos associated with narcan and morphine
17) Confidence 0.41 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16962578 Disease Relevance 0.06 Pain Relevance 1.01
To investigate the c-Fos expression, the anesthetized mice were transcardially perfused with 0.01M PBS, then with 4% paraformaldehyde (PFA) in PBS immediately after the above electrophysiological recordings.
Spec (investigate) Negative_regulation (investigate) of Spec (investigate) Gene_expression (expression) of c-Fos
18) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944835 Disease Relevance 0 Pain Relevance 0
Application of tetrodotoxin (0.2 microM) abolished the expression of c-Fos-immunoreactivity (n=6), but hexamethonium (100 microM) failed to decrease the number of c-Fos-positive neurons despite a complete suppression of spontaneous peristaltic movements (n=5).
Negative_regulation (abolished) of Gene_expression (expression) of c-Fos in neurons associated with tetrodotoxin
19) Confidence 0.41 Published 2002 Journal Brain Res. Section Abstract Doc Link 12383950 Disease Relevance 0 Pain Relevance 0.21
In the PCDM analysis (Fig. 3), both the unilateral and bilateral stimulation groups yielded c-Fos expression in the barrel fields of the primary somatosensory cortex.
Negative_regulation (yielded) of Gene_expression (expression) of c-Fos in primary somatosensory cortex associated with primary somatosensory cortex
20) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864740 Disease Relevance 0 Pain Relevance 0.09

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