INT4907

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.69
Pain Relevance 3.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC7)
Anatomy Link Frequency
neurons 2
pancreas 1
lamina 1
platelet 1
MUC7 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 211 100.00 Very High Very High Very High
Paracetamol 12 99.24 Very High Very High Very High
agonist 19 98.70 Very High Very High Very High
Clonidine 5 98.54 Very High Very High Very High
narcan 3 97.76 Very High Very High Very High
Morphine 3 97.26 Very High Very High Very High
Dorsal horn neuron 27 97.04 Very High Very High Very High
Dismenorea 3 96.80 Very High Very High Very High
Enkephalin 2 85.12 High High
Dorsal horn 33 84.72 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 6 99.60 Very High Very High Very High
Dysmenorrhea 3 96.80 Very High Very High Very High
Hepatocellular Cancer 1 95.76 Very High Very High Very High
Adenocarcinoma 18 94.40 High High
Cancer 31 91.28 High High
Hyperplasia 2 82.56 Quite High
Death 4 81.44 Quite High
Ductal Carcinoma 2 75.84 Quite High
Reprotox - General 1 1 70.00 Quite High
Adenoma 2 69.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, no MUC2, MUC4, or MUC7 expression was detected in normal pancreas.


Gene_expression (expression) of MUC7 in pancreas
1) Confidence 0.67 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.81 Pain Relevance 0
Mechanism of acetaminophen-induced apoptosis in cultured cells: roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3.
Gene_expression (roles) of Mg2 associated with paracetamol and apoptosis
2) Confidence 0.65 Published 2004 Journal Basic Clin. Pharmacol. Toxicol. Section Title Doc Link 14725611 Disease Relevance 0.72 Pain Relevance 0.53
Morphine, naltrexone and naloxone inhibited the binding of [3H]clonidine to the alpha 2-adrenoceptors in human platelet membranes, provided that Mg2+ was present in the medium.
Gene_expression (present) of Mg2 in platelet associated with narcan, clonidine and morphine
3) Confidence 0.33 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1335419 Disease Relevance 0 Pain Relevance 1.06
Both secreted (MUC2, MUC5AC, MUC5B, and MUC7) and membrane bound (MUC1, MUC4, and MUC16) mucin forms have been reported to be expressed by ocular surface epithelia [6,21,22].
Gene_expression (expressed) of MUC7
4) Confidence 0.16 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0 Pain Relevance 0
Therefore, the tocolytic action of beta-agonists cannot be explained by an inhibition of ICa(s), whereas that of Mg2+ can be so explained.
Gene_expression (explained) of Mg2 associated with agonist
5) Confidence 0.01 Published 1992 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1323377 Disease Relevance 0 Pain Relevance 0.25
Therefore, the tocolytic action of beta-agonists cannot be explained by an inhibition of ICa(s), whereas that of Mg2+ can be so explained.
Gene_expression (explained) of Mg2 associated with agonist
6) Confidence 0.01 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1324372 Disease Relevance 0 Pain Relevance 0.19
Therefore, the tocolytic action of beta-agonists cannot be explained by an inhibition of ICa(s), whereas that of Mg2+ can be so explained.
Gene_expression (explained) of Mg2 associated with agonist
7) Confidence 0.01 Published 1992 Journal Mol. Cell. Biochem. Section Abstract Doc Link 1281264 Disease Relevance 0.10 Pain Relevance 0.23
In this study, we took advantage of a recently developed technique [11] to functionally identify different NMDA receptor subtypes with different Mg2+ sensitivities expressed by inhibitory and excitatory interneurons in lamina II.


Gene_expression (expressed) of Mg2 in lamina associated with nmda receptor
8) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0.06 Pain Relevance 0.40
Based on our experiments, both highly Mg2+ sensitive (NR2A/B) and poorly Mg2+ sensitive (NR2C/D) NMDA receptors are expressed by NK1R+ neurons.
Gene_expression (expressed) of Mg2 in neurons associated with nmda receptor
9) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.45
Based on our experiments, both highly Mg2+ sensitive (NR2A/B) and poorly Mg2+ sensitive (NR2C/D) NMDA receptors are expressed by NK1R+ neurons.
Gene_expression (expressed) of Mg2 in neurons associated with nmda receptor
10) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.44

General Comments

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