INT49082

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Context Info
Confidence 0.65
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 25
Disease Relevance 31.26
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MPZ) plasma membrane (MPZ)
Anatomy Link Frequency
lymphocyte 2
T cells 2
blood 1
extracellular matrix 1
Tooth 1
MPZ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 130 100.00 Very High Very High Very High
agonist 26 99.26 Very High Very High Very High
gABA 69 99.08 Very High Very High Very High
Sciatic nerve 2 98.40 Very High Very High Very High
Pain 24 97.48 Very High Very High Very High
c fibre 42 95.04 Very High Very High Very High
Inflammation 886 94.36 High High
antagonist 10 93.64 High High
dorsal root ganglion 13 90.00 High High
rheumatoid arthritis 14 80.32 Quite High
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 3465 100.00 Very High Very High Very High
Dengue 1263 99.80 Very High Very High Very High
Fever 69 99.36 Very High Very High Very High
Shock 223 99.34 Very High Very High Very High
Mouth Disease 1 99.28 Very High Very High Very High
Charcot Marie Tooth Disease 2 99.00 Very High Very High Very High
Infection 701 98.64 Very High Very High Very High
Pleural Effusion 24 98.28 Very High Very High Very High
Disease 571 98.12 Very High Very High Very High
Pressure Volume 2 Under Development 27 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[A familial Charcot-Marie-Tooth disease type 1B (CMTD1B) manifesting a new mutation of myelin P0 gene].
Gene_expression (mutation) of P0 in Tooth associated with charcot marie tooth disease and mouth disease
1) Confidence 0.65 Published 1994 Journal Rinsho Shinkeigaku Section Title Doc Link 7537189 Disease Relevance 0.99 Pain Relevance 0.12
P0: A mouse monoclonal antibody, 1E8, raised against the mammalian myelin protein, P0, was used at 1:4000 and was generously provided by Dr.
Gene_expression (raised) of P0
2) Confidence 0.65 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0.07 Pain Relevance 0
Both proved to be the children from whom blood was sampled three days after the onset of shock, while the three DSS children sampled two days after shock onset still exhibited a typical DSS gene expression profile.
Gene_expression (expression) of DSS gene in blood associated with shock and dengue hemorrhagic fever
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.52 Pain Relevance 0.12
We found that the declines in the PTI and MPP under the MH after MP application correlated with significant pain improvement.
Gene_expression (declines) of MPP associated with pain
4) Confidence 0.57 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.22 Pain Relevance 0.16
0.428; Kruskal Wallis test), we searched whether genes encoding factors regulating negatively T and NK functions were over-expressed in the DSS-gene signature.
Gene_expression (expressed) of DSS-gene associated with dengue hemorrhagic fever
5) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.12 Pain Relevance 0.03
Unsupervised hierarchical clustering discriminates DSS children from DF/DHF ones, revealing a DSS-gene signature
Gene_expression (signature) of DSS-gene associated with dengue and dengue hemorrhagic fever
6) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.91 Pain Relevance 0.03
A putative neutrophil origin of this gene expression pattern is however supported by the over-expression in DSS patients blood cells of transcripts encoding other neutrophil-related molecules such as the MMP8 matrix metalloprotease, CEACAM-6, CEACAM-8 and CD99L2 adhesion molecules (Tables 4 and S2) involved in the recruitment of neutrophils to vascular endothelia.
Gene_expression (expression) of DSS in neutrophils associated with dengue hemorrhagic fever and adhesions
7) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.22 Pain Relevance 0.25
Integrative analysis of the most significant individual genes and canonical pathways extended the finding that a large and diverse set of genes related to T but also to NK lymphocyte activity is under-expressed in DSS patients compared to DF and DHF counterparts (Table 2; non exhaustive list; individual p-values available in Table S2; and Figure 3).
Gene_expression (expressed) of DSS in lymphocyte associated with dengue and dengue hemorrhagic fever
8) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.32 Pain Relevance 0.14
Over-expression in the blood of DSS children of several repair and remodeling genes encoding extracellular matrix proteins, vasoactive mediators and matrix metalloproteases such as the MMP9, likely reflects a compensatory response to inflammatory insults, and a number of those genes products are now considered putative biomarkers in systemic inflammatory syndromes such as severe sepsis [100].
Gene_expression (expression) of DSS in extracellular matrix associated with inflammation, syndrome, dengue hemorrhagic fever and sepsis
9) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.50 Pain Relevance 0.18
Since lymphocyte counts did not differ between the DF, DHF and DSS children (p?
Gene_expression (children) of DSS in lymphocyte associated with dengue and dengue hemorrhagic fever
10) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.14 Pain Relevance 0.04
Two important questions arise about the DSS-associated transcriptional profile: are the observed modifications of genes expression the cause or the consequence of the pathology, and could these modifications have a predictive value?
Gene_expression (expression) of DSS associated with dengue hemorrhagic fever
11) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.46 Pain Relevance 0
The gene list generated at FDR10 included 2959 genes differentially expressed between DF, DHF and DSS patients groups (Table S2).
Gene_expression (groups) of DSS associated with dengue and dengue hemorrhagic fever
12) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 0.64 Pain Relevance 0
Based on ANOVA analysis, lists of genes differentially expressed between DF, DHF and DSS groups were generated using different false discovery rate (FDR) ranging from 0.05 up to 10%.
Gene_expression (groups) of DSS associated with dengue and dengue hemorrhagic fever
13) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 0.98 Pain Relevance 0
Our study has produced significant results, further discussed in the context of DSS pathophysiology.
Gene_expression (produced) of DSS associated with dengue hemorrhagic fever
14) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 2.69 Pain Relevance 0.04
T cells during a dengue infection have prolific and cross reactive effector functions in addition to producing copious amounts of cytokines that feature prominently in cases of DHF/DSS.
Gene_expression (producing) of DSS in T cells associated with dengue, dengue hemorrhagic fever, infection and cytokine
15) Confidence 0.26 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 2.09 Pain Relevance 0.15
DRB1*07 was protective against DF, DHF and DSS and DRB1*04 was protective against secondary DF in Cuban population [34], DHF or DSS in Mexican population [40].
Gene_expression (protective) of DSS associated with dengue hemorrhagic fever
16) Confidence 0.06 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.70 Pain Relevance 0
We noted with interest that Long et al. [9] also observed a significantly higher expression of LTF, DEFA3 and DEFA4 in patient samples with DSS [9].
Gene_expression (expression) of DSS associated with dengue hemorrhagic fever
17) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 0.82 Pain Relevance 0
Among them, the T allele at position 352 of the VDR gene was associated with resistance to DSS as well as homozygotes for the arginine variant at position 131 of the Fc?
Gene_expression (resistance) of DSS associated with dengue hemorrhagic fever
18) Confidence 0.05 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.19 Pain Relevance 0.08
RII gene were shown to be protective against DSS.
Gene_expression (protective) of DSS associated with dengue hemorrhagic fever
19) Confidence 0.05 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.12 Pain Relevance 0.07
0.4), and VL 04-05 (DSS: OR?
Gene_expression (0.4) of DSS associated with dengue hemorrhagic fever
20) Confidence 0.05 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.55 Pain Relevance 0

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