INT49087

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Context Info
Confidence 0.00
First Reported 1995
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 8.01
Pain Relevance 12.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rab38) vesicle-mediated transport (Rab38) Golgi apparatus (Rab38)
endoplasmic reticulum (Rab38) GTPase activity (Rab38) cytoplasm (Rab38)
Anatomy Link Frequency
neurons 6
blood 1
Neuronal 1
muscle 1
IB4 1
Rab38 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 38 100.00 Very High Very High Very High
tetrodotoxin 18 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Delta opioid receptors 2 100.00 Very High Very High Very High
Enkephalin 12 99.84 Very High Very High Very High
gABA 4 99.78 Very High Very High Very High
electroacupuncture 69 99.70 Very High Very High Very High
Inflammation 46 99.70 Very High Very High Very High
Nerve growth factor 10 99.50 Very High Very High Very High
qutenza 9 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 48 100.00 Very High Very High Very High
Diabetes Mellitus 30 100.00 Very High Very High Very High
INFLAMMATION 55 99.70 Very High Very High Very High
Nociception 33 97.92 Very High Very High Very High
Pressure And Volume Under Development 2 97.32 Very High Very High Very High
Urological Neuroanatomy 8 96.20 Very High Very High Very High
Pain 47 94.00 High High
Diabetic Neuropathy 5 86.44 High High
Aids-related Complex 4 85.24 High High
Hyperalgesia 7 84.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, neurons double-labeled with c-Fos and enkephalin in the rVLM were significantly increased in cats following EA stimulation (P<0.05).
Positive_regulation (increased) of rVLM in neurons associated with enkephalin and electroacupuncture
1) Confidence 0.00 Published 2004 Journal Brain Res. Section Abstract Doc Link 15567342 Disease Relevance 0.33 Pain Relevance 1.28
We hypothesized that this effect is mediated through a long-loop pathway involving opioid, nociceptin, and gamma-aminobutyric acid (GABA) receptor activation in the rVLM.
Positive_regulation (activation) of rVLM associated with gaba, orphanin and opioid
2) Confidence 0.00 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17890425 Disease Relevance 0.40 Pain Relevance 0.88
These results reconfirm and extend that KOP-r undergoes upregulation in response to chronic binge cocaine administration here, with an escalating dose.
Positive_regulation (upregulation) of KOP-r associated with cocaine
3) Confidence 0.40 Published 2007 Journal Synapse Section Abstract Doc Link 17621646 Disease Relevance 0 Pain Relevance 0.74
PGE(2) induced a rapid (<15 s) increase in TTX-R I(Na) that was associated with a hyperpolarizing shift in the G-V curve (3.4 +/- 0.7 mV), an increase in the rate of inactivation (4.21 +/- 0.7 ms at 0 mV), and no change in steady-state availability.
Positive_regulation (increase) of TTX-R
4) Confidence 0.30 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12205171 Disease Relevance 0.61 Pain Relevance 0.37
Under the voltage-clamp mode, application of PGE2 (0.01-10 microM) concentration-dependently increased the magnitude of the peak tetrodotoxin-resistant sodium current (TTX-R I(Na)) and this current was maximal at a concentration of 1 microM.
Positive_regulation (increased) of TTX-R in PGE2 associated with tetrodotoxin
5) Confidence 0.27 Published 2007 Journal Exp Brain Res Section Abstract Doc Link 16850322 Disease Relevance 0.34 Pain Relevance 0.26
We find that there are significantly higher levels of TTX-R expressed in the capsaicin-sensitive group but no difference in the levels of TTX-S.
Positive_regulation (levels) of TTX-R associated with qutenza
6) Confidence 0.12 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7537359 Disease Relevance 0.17 Pain Relevance 1.01
TTX-R I(Na) in diabetic DRG neurons was enhanced in amplitude (71.5+/-3.6pA/pF, n=10 versus 41.2+/-3.3pA/pF, n=8) and was activated at more negative potentials (V(1/2), -15.1+/-1.3 mV versus -9.6+/-1.4 mV), compared with that in control neurons.
Positive_regulation (enhanced) of TTX-R in neurons associated with dorsal root ganglion and diabetes mellitus
7) Confidence 0.09 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17339081 Disease Relevance 1.30 Pain Relevance 0.53
TTX-R I(Na) in diabetic DRG neurons was enhanced in amplitude (71.5+/-3.6pA/pF, n=10 versus 41.2+/-3.3pA/pF, n=8) and was activated at more negative potentials (V(1/2), -15.1+/-1.3 mV versus -9.6+/-1.4 mV), compared with that in control neurons.
Positive_regulation (activated) of TTX-R in neurons associated with dorsal root ganglion and diabetes mellitus
8) Confidence 0.09 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17339081 Disease Relevance 1.34 Pain Relevance 0.54
Thus, TTX-R I(Na), which is upregulated in the diabetic state, is likely to be more potently inhibited by submicromolar concentrations of LY333531.
Positive_regulation (upregulated) of TTX-R associated with diabetes mellitus
9) Confidence 0.09 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17339081 Disease Relevance 1.30 Pain Relevance 0.58
TTX-R Na(v)1.9 sodium current was also significantly increased, whereas no alteration of TTX-R Na(v)1.8 current was observed in neurons from diabetic rats.
Positive_regulation (increased) of TTX-R in neurons associated with diabetes mellitus
10) Confidence 0.04 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16310161 Disease Relevance 0.69 Pain Relevance 0.32
SPW-R activity occurs mainly during slow wave sleep and awake immobility [13,18], and it is also observed in high temporal proximity to the experienced event [19].
Positive_regulation (occurs) of SPW-R
11) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0.14 Pain Relevance 0.04
In vitro SPW-R activity presents certain experimental advantages including its spontaneous generation in hippocampal slices under standard conditions without being induced by pharmacological agents or other experimental manipulation.
Neg (without) Positive_regulation (induced) of SPW-R
12) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0.13 Pain Relevance 0
Tetrodotoxin-resistant (TTX-R) sodium current in small-size dorsal root ganglia (DRG) neurons is upregulated by prostaglandin E(2) and serotonin through a protein kinase A (PKA)/protein kinase (PKC) pathway, suggesting G protein modulation of one or more TTX-R channels in these neurons.
Positive_regulation (upregulated) of TTX-R in neurons associated with tetrodotoxin and serotonin
13) Confidence 0.04 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12898089 Disease Relevance 0 Pain Relevance 0.22
Neuronal activity in the rVLM induced by splanchnic nerve stimulation was reduced for 50 (or more) min after termination of EA in 7 of 12 rVLM neurons.
Positive_regulation (induced) of rVLM in Neuronal associated with electroacupuncture
14) Confidence 0.02 Published 2003 Journal Auton Neurosci Section Abstract Doc Link 12878081 Disease Relevance 0.07 Pain Relevance 0.50
Our results indicate that the inhibitory effect of EA on the BK-induced pressor response and the consequent improvement of ischemic dysfunction is dependent on the activation of opioid receptors, specifically receptors located in the rVLM.
Positive_regulation (activation) of rVLM associated with opioid receptor, bradykinin and electroacupuncture
15) Confidence 0.01 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10362696 Disease Relevance 0 Pain Relevance 0.57
The data suggest that NGF has a major role in the maintenance of steady-state levels of TTX-R sodium currents and SNS mRNA in IB4(-) DRG neurons in adult rats in vivo.
Positive_regulation (maintenance) of TTX-R in DRG associated with dorsal root ganglion and nerve growth factor
16) Confidence 0.01 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10036280 Disease Relevance 0.58 Pain Relevance 0.77
Despite the much smaller N, the increase in TTX-R current was still statistically significant in both IB4-positive (overall p = 0.019) and IB4-negative (p = 0.002) cells.
Positive_regulation (increase) of TTX-R in IB4
17) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.06
As shown in Figure 2, GRO/KC incubation (16 to 30 hours) significantly increased the density both TTX-R and TTX-S currents.
Positive_regulation (increased) of TTX-R
18) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.09
Using the same model, we found that localized inflammation led to marked increases in TTX-S and TTX-R currents in small diameter DRG neurons, as well as increased excitability, as determined by patch clamp studies in acutely isolated neurons [7].
Positive_regulation (increases) of TTX-R in neurons associated with inflammation
19) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.52 Pain Relevance 0.43
Thus, in addition to the classical opioid system, nociceptin, through opioid receptor-like-1 receptor stimulation in the rVLM, participates in the modulatory influence of EA on reflex-induced increases in blood pressure.
Positive_regulation (stimulation) of rVLM in blood associated with pressure and volume under development, orphanin, opioid receptor, electroacupuncture and opioid
20) Confidence 0.00 Published 2005 Journal J. Appl. Physiol. Section Abstract Doc Link 15649868 Disease Relevance 0.10 Pain Relevance 1.17

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