INT49089

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 6.79
Pain Relevance 13.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rab38) vesicle-mediated transport (Rab38) Golgi apparatus (Rab38)
endoplasmic reticulum (Rab38) GTPase activity (Rab38) cytoplasm (Rab38)
Anatomy Link Frequency
neurons 8
DRG 4
IB4 2
medial entorhinal cortex 1
afferent neurons 1
Rab38 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 69 100.00 Very High Very High Very High
sodium channel 19 100.00 Very High Very High Very High
dorsal root ganglion 44 99.84 Very High Very High Very High
qutenza 20 99.68 Very High Very High Very High
ketamine 20 99.68 Very High Very High Very High
nociceptor 12 98.76 Very High Very High Very High
Pyramidal cell 10 98.40 Very High Very High Very High
Pain 4 98.28 Very High Very High Very High
Nerve growth factor 30 98.04 Very High Very High Very High
Spinal cord 14 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 58 99.76 Very High Very High Very High
Syndrome 3 98.68 Very High Very High Very High
Spinal Cord Injury 6 98.52 Very High Very High Very High
Pain 4 98.28 Very High Very High Very High
Hyperalgesia 7 97.68 Very High Very High Very High
Nociception 9 97.44 Very High Very High Very High
Diabetes Mellitus 9 97.16 Very High Very High Very High
Hypoalagesia 3 94.88 High High
Sleep Disorders 4 74.64 Quite High
INFLAMMATION 4 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mid-point of activation exhibited a greater shift to a more hyperpolarized potential in the neurons co-expressing TTX-R and persistent TTX-R Na(+) currents than those expressing TTX-R only.
Gene_expression (expressing) of TTX-R in neurons
1) Confidence 0.45 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17336926 Disease Relevance 0 Pain Relevance 0.11
TTX-R I(Na) was present in every colonic DRG neuron studied (n = 62).
Gene_expression (present) of TTX-R in DRG associated with dorsal root ganglion
2) Confidence 0.38 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12205171 Disease Relevance 0.62 Pain Relevance 0.38
Two types of Na(+) channels, tetrodotoxin (TTX)-sensitive (TTX-s) and TTX-resistant (TTX-r), are expressed in dorsal root ganglion (DRG) neurons.
Gene_expression (expressed) of TTX-r in DRG associated with ganglion cysts, dorsal root ganglion and tetrodotoxin
3) Confidence 0.35 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10922523 Disease Relevance 0.43 Pain Relevance 1.61
Since TTX-r Na(+) channels were preferentially expressed in small DRG neurons known as nociceptors, blockage of TTX-r Na(+) channels by ketamine may result in reducing nociceptive signals conducting to the spinal cord.
Gene_expression (expressed) of TTX-r in neurons associated with nociception, dorsal root ganglion, tetrodotoxin, ketamine, nociceptor and spinal cord
4) Confidence 0.35 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10922523 Disease Relevance 0.56 Pain Relevance 2.54
The mid-point of activation exhibited a greater shift to a more hyperpolarized potential in the neurons co-expressing TTX-R and persistent TTX-R Na(+) currents than those expressing TTX-R only.
Gene_expression (expressing) of TTX-R in neurons
5) Confidence 0.35 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17336926 Disease Relevance 0 Pain Relevance 0.11
However, wheteher nodose neurons functionally express persistent TTX-R Na(+) currents has not been reported.
Gene_expression (express) of TTX-R in neurons
6) Confidence 0.35 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17336926 Disease Relevance 0 Pain Relevance 0.07
The mid-point of activation exhibited a greater shift to a more hyperpolarized potential in the neurons co-expressing TTX-R and persistent TTX-R Na(+) currents than those expressing TTX-R only.
Gene_expression (expressing) of TTX-R in neurons
7) Confidence 0.35 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17336926 Disease Relevance 0 Pain Relevance 0.11
It has been documented that nodose neurons express TTX-sensitive (TTX-S) and TTX-resistant (TTX-R) Na(+) channels.
Gene_expression (express) of TTX-R in neurons
8) Confidence 0.35 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17336926 Disease Relevance 0 Pain Relevance 0.07
ITTX-R was found in both putative stellate and putative pyramidal neurons from the medial entorhinal cortex.
Gene_expression (found) of ITTX-R in medial entorhinal cortex associated with pyramidal cell
9) Confidence 0.30 Published 1993 Journal Neuron Section Abstract Doc Link 8274275 Disease Relevance 0 Pain Relevance 0.41
We find that there are significantly higher levels of TTX-R expressed in the capsaicin-sensitive group but no difference in the levels of TTX-S.
Gene_expression (expressed) of TTX-R associated with qutenza
10) Confidence 0.21 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7537359 Disease Relevance 0.17 Pain Relevance 1.02
We find that there are significantly higher levels of TTX-R expressed in the capsaicin-sensitive group but no difference in the levels of TTX-S.
Gene_expression (expressed) of TTX-R associated with qutenza
11) Confidence 0.18 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7537359 Disease Relevance 0.17 Pain Relevance 1.02
We have used conventional whole-cell electrophysiological recording techniques to measure the level of expression of tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in the capsaicin-sensitive and capsaicin-insensitive subpopulations of dorsal root ganglion neurons.
Gene_expression (expression) of TTX-R in neurons associated with ganglion cysts, tetrodotoxin, qutenza and root ganglion neuron
12) Confidence 0.14 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7537359 Disease Relevance 0.17 Pain Relevance 0.97
Five cells expressed TTX-R current only and one cell only the TTX-S current.
Gene_expression (expressed) of TTX-R
13) Confidence 0.11 Published 2002 Journal Brain Res. Section Abstract Doc Link 12144854 Disease Relevance 0.32 Pain Relevance 0.40
This study provides complementary new information that there is a distinct difference in the expression level of TTX-S and TTX-R Na+ channels between IB4-negative than IB4-positive small-diameter DRG neurons.
Gene_expression (expression) of TTX-R in IB4 associated with dorsal root ganglion
14) Confidence 0.08 Published 2004 Journal Brain Res. Section Abstract Doc Link 15542080 Disease Relevance 0.44 Pain Relevance 0.55
These results demonstrate that the expression of TTX-R channels in bladder afferent neurons changes after spinal cord transection, and these changes may contribute to the increased excitability of these neurons following spinal cord injury.
Gene_expression (expression) of TTX-R in afferent neurons associated with spinal cord
15) Confidence 0.06 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560118 Disease Relevance 0.29 Pain Relevance 0.53
Tetrodotoxin-resistant (TTX-R) sodium channels Na(v)1.8/SNS and Na(v)1.9/NaN are preferentially expressed in small diameter dorsal root ganglia (DRG) neurons.
Gene_expression (expressed) of TTX-R in dorsal root ganglia associated with tetrodotoxin and sodium channel
16) Confidence 0.06 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560118 Disease Relevance 0 Pain Relevance 0.39
Phenobarbital effects on in vitro SPW-R complexes
Gene_expression (complexes) of SPW-R
17) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0.07 Pain Relevance 0.10
The expressions of nNOS and TTX-R Na channels were not changed with LY treatment.
Gene_expression (expressions) of TTX-R
18) Confidence 0.04 Published 2003 Journal Diabetes Section Abstract Doc Link 12882929 Disease Relevance 1.42 Pain Relevance 0.67
To determine whether SNS expression and TTX-R currents in DRG neurons are affected by reduced levels of systemic NGF, we immunized adult rats with NGF, which causes thermal hypoalgesia in rats with high antibody titers to NGF.
Gene_expression (expression) of TTX-R in neurons associated with dorsal root ganglion, nerve growth factor and hypoalgesia
19) Confidence 0.01 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10036280 Disease Relevance 0.73 Pain Relevance 0.85
In vivo NGF deprivation reduces SNS expression and TTX-R sodium currents in IB4-negative DRG neurons.
Gene_expression (expression) of TTX-R in IB4
20) Confidence 0.01 Published 1999 Journal J. Neurophysiol. Section Title Doc Link 10036280 Disease Relevance 0.68 Pain Relevance 0.80

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