INT4909

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Context Info
Confidence 0.51
First Reported 1982
Last Reported 2010
Negated 35
Speculated 11
Reported most in Abstract
Documents 480
Total Number 492
Disease Relevance 117.27
Pain Relevance 205.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OASB) plastid (OASB)
Anatomy Mention Frequency
neuronal 29
nerve 12
spinal 10
blood 7
endothelium 7
OASB (Arabidopsis thaliana)
Pain Term Frequency Confidence Heat
opioid receptor 49 100.00 Very High Very High Very High
cytokine 37 100.00 Very High Very High Very High
Morphine 424 100.00 Very High Very High Very High
Enkephalin 74 100.00 Very High Very High Very High
narcan 88 100.00 Very High Very High Very High
Pain 178 100.00 Very High Very High Very High
antagonist 195 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 11 100.00 Very High Very High Very High
guanethidine 6 100.00 Very High Very High Very High
Antinociceptive 137 100.00 Very High Very High Very High
Disease Term Frequency Confidence Heat
Targeted Disruption 16 100.00 Very High Very High Very High
Nociception 142 100.00 Very High Very High Very High
Pain 107 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 104 99.92 Very High Very High Very High
Death 17 99.92 Very High Very High Very High
Acidosis 3 99.84 Very High Very High Very High
Metabolic Disorder 1 99.80 Very High Very High Very High
Fungal Infection 3 99.74 Very High Very High Very High
INFLAMMATION 105 99.72 Very High Very High Very High
Stress 33 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Preemptive blockade of NO synthase is important in preventing NSAID-induced duodenal injury in rats.
Negative_regulation (blockade) of NO synthase
1) Confidence 0.51 Published 2000 Journal Comp. Med. Section Body Doc Link 10857004 Disease Relevance 0 Pain Relevance 0
These changes were enhanced by the blockade of NO-synthase.
Negative_regulation (blockade) of NO-synthase
2) Confidence 0.50 Published 2010 Journal Morfologiia Section Abstract Doc Link 20572397 Disease Relevance 0.28 Pain Relevance 0.62
Electrical stimulation of the tissues induced an increase in photon counts which was frequency-dependent and prevented by inhibition of the NO synthase or by tetrodotoxin.
Negative_regulation (inhibition) of NO synthase associated with tetrodotoxin
3) Confidence 0.49 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9008153 Disease Relevance 0 Pain Relevance 0.10
Pretreatment with NG-nitro-L-arginine (L-NNA), an inhibitor of NO synthase, enhanced ethanol-induced mucosal damage and reduced dose-dependently the gastroprotective and hyperemic effects of sucralfate, dilute ethanol, and capsaicin.
Negative_regulation (inhibitor) of NO synthase associated with qutenza
4) Confidence 0.49 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 8131698 Disease Relevance 0 Pain Relevance 0.35
The results suggest that the release of l-citrulline in NAcc may be involved in the processes of morphine withdrawal and agmatine as an endogenous inhibitor of NO synthase may be one of the factors involved in the changes in the physiology and behavioral state during opioid withdrawal and may have pharmacological importance.
Negative_regulation (inhibitor) of NO synthase associated with opioid, withdrawal and morphine
5) Confidence 0.49 Published 2007 Journal Brain Res. Section Abstract Doc Link 17182008 Disease Relevance 0.23 Pain Relevance 1.09
Nomega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthase, decreased stimulation-evoked norepinephrine release in middle cerebral arteries from normoxic sheep with no effect in hypoxic arteries or facial arteries.
Negative_regulation (inhibitor) of NO synthase associated with hypoxia
6) Confidence 0.49 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10070141 Disease Relevance 0.52 Pain Relevance 0.28
As has been observed in rats, chronic inhibition of NO synthase in mice results in arterial hypertension.
Negative_regulation (inhibition) of NO synthase associated with pressure and volume under development
7) Confidence 0.49 Published 2001 Journal Hypertension Section Abstract Doc Link 11566930 Disease Relevance 0.29 Pain Relevance 0.07
Pretreatments with four inhibitors of NO synthase, 7-nitro indazole, 3-bromo-7-nitro indazole, S-methyl-L-thiocitrulline and aminoguanidine, which exhibit different isoform selectivity in vitro, were evaluated for their ability to attenuate signs of naloxone-precipitated morphine withdrawal.
Negative_regulation (inhibitors) of synthase associated with narcan, withdrawal and morphine
8) Confidence 0.39 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9137908 Disease Relevance 0 Pain Relevance 0.54
Aminoguanidine, which selectively inhibits inducible NO synthase, reduced fewer signs of opioid withdrawal, had a lower relative potency and exhibited no vasopressor activity.
Negative_regulation (inhibits) of synthase associated with withdrawal, opioid and potency
9) Confidence 0.39 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9137908 Disease Relevance 0.10 Pain Relevance 0.82
Nitric oxide synthase inhibition: a new principle in the treatment of migraine attacks.
Negative_regulation (inhibition) of synthase associated with migraine
10) Confidence 0.38 Published 1998 Journal Cephalalgia Section Title Doc Link 9601621 Disease Relevance 0.69 Pain Relevance 0.68
NO deficiency, caused by NO-synthase blockade, lead to disturbances of vascular bed control, resulting in ischemia and hypoxia, and, as a consequence, in dystrophic and necrotic changes in hepatocytes.
Negative_regulation (blockade) of NO-synthase in hepatocytes associated with hypoxia and ischemia
11) Confidence 0.37 Published 2010 Journal Morfologiia Section Abstract Doc Link 20572397 Disease Relevance 0.29 Pain Relevance 0.63
Inhibition of NO synthase with 25 mg/kg i.v.
Negative_regulation (Inhibition) of NO synthase
12) Confidence 0.36 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 7761253 Disease Relevance 0.23 Pain Relevance 0.64
NO synthase inhibition abolished the cardioprotection by postconditioning, both IPC stimuli, and the combination of postconditioning and either IPC stimulus.
Negative_regulation (inhibition) of NO synthase
13) Confidence 0.36 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19657069 Disease Relevance 0.14 Pain Relevance 0.16
For the comparison, the administration of indomethacin to suppress the generation of prostaglandin biosynthesis, also reduced basal and stimulated alkaline secretion but this reduction was relatively smaller than that attained by the inhibition of NO synthase with L-NNA.
Negative_regulation (inhibition) of NO synthase
14) Confidence 0.36 Published 1994 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 7727796 Disease Relevance 0 Pain Relevance 0.22
A cannula was inserted into the left RVLM for microinjection of NO synthase inhibitor, S-methyl-L-thiocitruline (MeTC) or NO donor, S-nitroso-N-acetyl-penicillamine (SNAP).
Negative_regulation (inhibitor) of NO synthase in RVLM associated with rostral ventrolateral medulla
15) Confidence 0.36 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 14985829 Disease Relevance 0.45 Pain Relevance 0.25
To assess the role of nitric oxide (NO) on the observed responses, N G-nitro-L-arginine methyl ester (L-NAME, NO synthase inhibitor) was applied topically (0.2 micromol) 5 min before phenylephrine application.
Negative_regulation (inhibitor) of NO synthase
16) Confidence 0.36 Published 2000 Journal Exp. Physiol. Section Abstract Doc Link 10662892 Disease Relevance 0.07 Pain Relevance 0.35
The effects of L-arginine, the physiological precursor of nitric oxide (NO), and inhibitors of NO-synthase on the antinociceptive action of Ukrain (4.75, 9.5, and 19.0 mg/kg i.p.) were investigated using the writhing syndrome test in mice.
Negative_regulation (inhibitors) of NO-synthase associated with syndrome and antinociceptive
17) Confidence 0.36 Published 1998 Journal Drugs Exp Clin Res Section Abstract Doc Link 10190096 Disease Relevance 0.17 Pain Relevance 0.21
In addition, the inhibitors of NO-synthase NG-nitro-L-arginine methyl ester (L-NAME) (1.0 and 10 mg/kg i.p.), 7-nitroindazole (1.0 mg/kg i.p.) and NG-monomethyl-L-arginine acetate (L-NMMA) (1.0 mg/kg i.p.) significantly enhanced Ukrain-induced antinociception.
Negative_regulation (inhibitors) of NO-synthase associated with antinociception
18) Confidence 0.36 Published 1998 Journal Drugs Exp Clin Res Section Abstract Doc Link 10190096 Disease Relevance 0.17 Pain Relevance 0.26
In the present study we evaluated the cardiovascular responses to inhibition of endogenous nitric oxide (NO) formation in the brain with intracerebroventricular (i.c.v) administration of N omega-nitro-L-arginine methyl ester (L-NAME), a specific inhibitor of NO synthase.
Negative_regulation (inhibitor) of synthase in brain associated with intracerebroventricular
19) Confidence 0.34 Published 1997 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 9098838 Disease Relevance 0.08 Pain Relevance 0.05
Miglustat, a glucosylceramide synthase inhibitor, may have a positive influence on GD bone disease.
Negative_regulation (inhibitor) of synthase associated with gauchers disease and bone cancer
20) Confidence 0.34 Published 2007 Journal Clin Ther Section Abstract Doc Link 17919546 Disease Relevance 0.82 Pain Relevance 0

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