INT49103

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 71
Total Number 74
Disease Relevance 59.52
Pain Relevance 19.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) aging (Vcam1) cell adhesion (Vcam1)
Anatomy Link Frequency
plasma 16
leukocytes 4
monocytes 2
heart 2
endothelium 2
Vcam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory marker 54 100.00 Very High Very High Very High
Sciatic nerve 2 100.00 Very High Very High Very High
Angina 156 99.96 Very High Very High Very High
Cluster headache 10 99.66 Very High Very High Very High
Restless leg syndrome 33 99.60 Very High Very High Very High
Chronic pancreatitis 18 99.24 Very High Very High Very High
Neuritis 12 99.20 Very High Very High Very High
aspirin 53 98.88 Very High Very High Very High
rheumatoid arthritis 93 98.64 Very High Very High Very High
Inflammation 303 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 407 100.00 Very High Very High Very High
Adhesions 260 100.00 Very High Very High Very High
Apoptosis 33 100.00 Very High Very High Very High
Sepsis 30 100.00 Very High Very High Very High
Hyperglycemia 27 99.98 Very High Very High Very High
Cv General 3 Under Development 128 99.96 Very High Very High Very High
Adult Respiratory Distress Syndrome 57 99.96 Very High Very High Very High
Stable Angina Pectoris 26 99.84 Very High Very High Very High
Angina 14 99.72 Very High Very High Very High
Lung Injury 29 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of sVCAM-1 were further elevated during ACS (P < 0.001) and APE (P = 0.072) and returned to the asymptomatic range on resolution.
Positive_regulation (elevated) of sVCAM-1 associated with acute chest syndrome
1) Confidence 0.69 Published 2004 Journal Am. J. Hematol. Section Abstract Doc Link 15114598 Disease Relevance 1.23 Pain Relevance 0.11
In support of this hypothesis, endothelial cells exposed to the synthetic double-stranded RNA poly(I:C) or the RNA virus parainfluenza 1 (Sendai virus) express increased levels of VCAM-1 and support increased sickle erythrocyte adherence under continuous flow at 1.0 dyne/cm2 shear stress as compared with unstimulated endothelium.
Positive_regulation (increased) of VCAM-1 in poly associated with stress and parainfluenza virus infection
2) Confidence 0.60 Published 1995 Journal Blood Section Abstract Doc Link 7537985 Disease Relevance 1.05 Pain Relevance 0.17
However, only those patients with class II and III unstable AP had significantly higher circulating levels of VCAM-1 than patients with stable AP (P < 0.0001).
Positive_regulation (levels) of VCAM-1 associated with angina
3) Confidence 0.50 Published 2005 Journal International heart journal Section Abstract Doc Link 16157948 Disease Relevance 1.43 Pain Relevance 1.32
In the acute phase of experimental autoimmune encephalomyelitis and neuritis VCAM-1 mRNA was expressed not only on the luminal surface of inflamed vessels but also in perivascular cells suggesting a functional role of VCAM-1 in both endothelial adhesion and local restimulation of autoantigen-specific T cells.
Positive_regulation (role) of VCAM-1 in T cells associated with multiple sclerosis, neuritis and adhesions
4) Confidence 0.50 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862137 Disease Relevance 0.87 Pain Relevance 0.13
In patients who had unstable angina pectoris and non-ST-segment elevation myocardial infarction, initial blood levels of soluble vascular cell adhesion molecule-1 were found not to be higher than those in asymptomatic patients who had coronary artery disease.
Positive_regulation (higher) of vascular cell adhesion molecule-1 in blood associated with angina, coronary artery disease, adhesions and myocardial infarction
5) Confidence 0.48 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 16054462 Disease Relevance 0.79 Pain Relevance 0.35
Soluble vascular cell adhesion molecule, type-1 (soluble VCAM-1) was identified as a major mediator of the adhesive interactions [19,30].
Positive_regulation (mediator) of VCAM-1 associated with adhesions
6) Confidence 0.47 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.49 Pain Relevance 0.13
, caspase-3, type III procollagen (PCIII), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) mRNA expressions in lung tissue, as well as lung and distal organ epithelial cell apoptosis in an experimental model of sepsis-induced ALI.


Positive_regulation (induced) of vascular cell adhesion molecule in epithelial cell associated with adult respiratory distress syndrome, apoptosis, sepsis and adhesions
7) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.70 Pain Relevance 0
On immunohistochemical examination, VCAM-1 in sciatic nerve was found to be upregulated at early stages of EAN (days 3-5 after T-cell transfer), whilst no expression was noted in healthy controls.
Positive_regulation (upregulated) of VCAM-1 in T-cell associated with sciatic nerve and neuritis
8) Confidence 0.41 Published 1998 Journal Brain Section Abstract Doc Link 9679778 Disease Relevance 1.55 Pain Relevance 1.00
Elevated plasma sVCAM-1 levels in children with sickle cell disease: impact of chronic transfusion therapy.
Positive_regulation (Elevated) of sVCAM-1 in plasma associated with sickle cell anemia
9) Confidence 0.40 Published 2004 Journal Am. J. Hematol. Section Title Doc Link 15114598 Disease Relevance 1.12 Pain Relevance 0.12
[Concentration of serum soluble forms of ICAM-1 (sVCAM-1) and VCAM-1 (sVCAM-1) in patients with chronic pancreatitis and in patients with pancreatic carcinoma].
Positive_regulation ([Concentration) of VCAM-1 associated with pancreatic cancer and chronic pancreatitis
10) Confidence 0.38 Published 2003 Journal Wiad. Lek. Section Title Doc Link 12923961 Disease Relevance 1.17 Pain Relevance 0.39
[Concentration of serum soluble forms of ICAM-1 (sVCAM-1) and VCAM-1 (sVCAM-1) in patients with chronic pancreatitis and in patients with pancreatic carcinoma].
Positive_regulation ([Concentration) of sVCAM-1 associated with pancreatic cancer and chronic pancreatitis
11) Confidence 0.38 Published 2003 Journal Wiad. Lek. Section Title Doc Link 12923961 Disease Relevance 1.22 Pain Relevance 0.39
[Concentration of serum soluble forms of ICAM-1 (sVCAM-1) and VCAM-1 (sVCAM-1) in patients with chronic pancreatitis and in patients with pancreatic carcinoma].
Positive_regulation ([Concentration) of sVCAM-1 associated with pancreatic cancer and chronic pancreatitis
12) Confidence 0.38 Published 2003 Journal Wiad. Lek. Section Title Doc Link 12923961 Disease Relevance 1.16 Pain Relevance 0.39
The circulating levels of hs-CRP and VCAM-1 were also evaluated in 40 healthy volunteers.
Positive_regulation (evaluated) of VCAM-1
13) Confidence 0.36 Published 2005 Journal International heart journal Section Abstract Doc Link 16157948 Disease Relevance 1.41 Pain Relevance 1.09
The serum levels of sICAM-1, sVCAM-1 were markedly elevated in patients with acute myocardial infarction, unstable angina pectoris and stable heart disease compared to control group (p < 0.001, p < 0.004, p < 0.0002 for sICAM-1, p < 0.007, p < 0.003, p < 0.004 for sVCAM-1).
Positive_regulation (elevated) of sVCAM-1 in heart associated with angina, heart disease and myocardial infarction
14) Confidence 0.36 Published 2003 Journal Prz. Lek. Section Abstract Doc Link 14750416 Disease Relevance 1.72 Pain Relevance 0.57
In patients with UAP, VCAM-1 was found to be significantly elevated as compared to the SAP group and controls.
Positive_regulation (elevated) of VCAM-1 associated with angina
15) Confidence 0.35 Published 2004 Journal Int. J. Cardiol. Section Abstract Doc Link 15262039 Disease Relevance 2.20 Pain Relevance 1.21
Bone marrow cells implantation induced angiogenesis in a rat ischemic heart model as a result of increase of the levels of vascular endothelial growth factor, vascular cell adhesion molecule, interleukin-1, and tumor necrosis factor-?.



Positive_regulation (increase) of vascular cell adhesion molecule in heart associated with necrosis, cancer and adhesions
16) Confidence 0.34 Published 2008 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2414821 Disease Relevance 0.79 Pain Relevance 0.16
In conclusion, circulating levels of hs-CRP, WBC count, and VCAM-1 were significantly increased in patients with AP.
Positive_regulation (increased) of VCAM-1 in WBC associated with angina
17) Confidence 0.34 Published 2005 Journal International heart journal Section Abstract Doc Link 16157948 Disease Relevance 1.03 Pain Relevance 1.05
OBJECTIVE: The purpose of this study was to assess whether the plasma levels of soluble adhesion molecules including E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are elevated in patients with variant angina and whether they are released in the coronary circulation.
Spec (whether) Positive_regulation (elevated) of VCAM-1 in plasma associated with angina and adhesions
18) Confidence 0.33 Published 1997 Journal Cardiovasc. Res. Section Abstract Doc Link 9415270 Disease Relevance 0.47 Pain Relevance 0.17
Exercise increases soluble adhesion molecules ICAM-1 and VCAM-1 in patients with intermittent claudication.
Positive_regulation (increases) of VCAM-1 associated with restless leg syndrome and adhesions
19) Confidence 0.32 Published 2001 Journal Clin. Hemorheol. Microcirc. Section Title Doc Link 11455059 Disease Relevance 0.80 Pain Relevance 0.19
These findings indicate that, in claudicants, exercise is associated with increase in plasma levels of sICAM-1 and sVCAM-1.
Positive_regulation (increase) of sVCAM-1 in plasma
20) Confidence 0.32 Published 2001 Journal Clin. Hemorheol. Microcirc. Section Abstract Doc Link 11455059 Disease Relevance 0.62 Pain Relevance 0.13

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