INT49104

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 30
Total Number 33
Disease Relevance 36.52
Pain Relevance 7.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) aging (Vcam1) cell adhesion (Vcam1)
Anatomy Link Frequency
endothelial cells 9
neutrophils 6
plasma 4
epithelial cell 4
stromal cells 4
Vcam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 11 99.70 Very High Very High Very High
Angina 9 99.28 Very High Very High Very High
Chronic pancreatitis 30 98.08 Very High Very High Very High
aspirin 10 98.04 Very High Very High Very High
Inflammation 208 97.72 Very High Very High Very High
cytokine 68 97.24 Very High Very High Very High
Inflammatory response 36 96.44 Very High Very High Very High
Sciatic nerve 2 95.04 Very High Very High Very High
Catecholamine 92 95.00 High High
Acute pain 3 92.56 High High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 420 100.00 Very High Very High Very High
Sepsis 150 100.00 Very High Very High Very High
Adhesions 142 100.00 Very High Very High Very High
Apoptosis 64 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 266 99.96 Very High Very High Very High
Experimental Autoimmune Neuritis 11 99.70 Very High Very High Very High
Acute Chest Syndrome 18 99.68 Very High Very High Very High
Parainfluenza Virus Infection 4 99.64 Very High Very High Very High
Necrosis 13 99.48 Very High Very High Very High
Lyme Disease 74 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings of increased VCAM-1 expression during ACS and perhaps APE offer a rationale for therapeutic use of cytokine and other VCAM-1 modulators.
Positive_regulation (increased) of Gene_expression (expression) of VCAM-1 associated with acute chest syndrome and cytokine
1) Confidence 0.69 Published 2004 Journal Am. J. Hematol. Section Abstract Doc Link 15114598 Disease Relevance 1.18 Pain Relevance 0.11
Based on these observations, the hypothesis was developed that viral infection, through double-stranded RNA intermediates, increases endothelial VCAM-1 expression leading to sickle erythrocyte adhesion to endothelium via an alpha 4 beta 1-VCAM-1--dependent mechanism.
Positive_regulation (increases) of Gene_expression (expression) of VCAM-1 in erythrocyte associated with viral infection and adhesions
2) Confidence 0.60 Published 1995 Journal Blood Section Abstract Doc Link 7537985 Disease Relevance 1.08 Pain Relevance 0.18
The relationship of these two variables showed strong positive correlation in which the magnitude of leukocyte infiltration into the synovial cavity was dependent on the concentration of soluble VCAM-1 produced in the blood.
Positive_regulation (dependent) of Gene_expression (produced) of VCAM-1 in cavity
3) Confidence 0.47 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.44 Pain Relevance 0.14
These experiments demonstrate the critical role of VLA-4 in the pathogenesis of EAN and show that upregulation of VCAM-1 expression contributes, at least in part, to the progression of the disease in the early stages.
Positive_regulation (upregulation) of Gene_expression (expression) of VCAM-1 associated with disease and neuritis
4) Confidence 0.47 Published 1998 Journal Brain Section Abstract Doc Link 9679778 Disease Relevance 1.44 Pain Relevance 0.88
Levels of sVCAM-1 were further elevated during ACS (P < 0.001) and APE (P = 0.072) and returned to the asymptomatic range on resolution.
Positive_regulation (elevated) of Gene_expression (Levels) of sVCAM-1 associated with acute chest syndrome
5) Confidence 0.46 Published 2004 Journal Am. J. Hematol. Section Abstract Doc Link 15114598 Disease Relevance 1.23 Pain Relevance 0.11
Elevated plasma sVCAM-1 levels in children with sickle cell disease: impact of chronic transfusion therapy.
Positive_regulation (Elevated) of Gene_expression (levels) of sVCAM-1 in plasma associated with sickle cell anemia
6) Confidence 0.43 Published 2004 Journal Am. J. Hematol. Section Title Doc Link 15114598 Disease Relevance 1.13 Pain Relevance 0.12
Double-stranded RNA has been shown to induce vascular cell adhesion molecule-1 (VCAM-1) protein expression on endothelial cells.
Positive_regulation (induce) of Gene_expression (expression) of VCAM-1 in endothelial cells associated with adhesions
7) Confidence 0.43 Published 1995 Journal Blood Section Abstract Doc Link 7537985 Disease Relevance 0.96 Pain Relevance 0.20
Double-stranded RNA has been shown to induce vascular cell adhesion molecule-1 (VCAM-1) protein expression on endothelial cells.
Positive_regulation (induce) of Gene_expression (expression) of vascular cell adhesion molecule-1 in endothelial cells associated with adhesions
8) Confidence 0.43 Published 1995 Journal Blood Section Abstract Doc Link 7537985 Disease Relevance 0.96 Pain Relevance 0.20
In support of this hypothesis, endothelial cells exposed to the synthetic double-stranded RNA poly(I:C) or the RNA virus parainfluenza 1 (Sendai virus) express increased levels of VCAM-1 and support increased sickle erythrocyte adherence under continuous flow at 1.0 dyne/cm2 shear stress as compared with unstimulated endothelium.
Positive_regulation (increased) of Gene_expression (express) of VCAM-1 in poly associated with stress and parainfluenza virus infection
9) Confidence 0.43 Published 1995 Journal Blood Section Abstract Doc Link 7537985 Disease Relevance 1.05 Pain Relevance 0.17
, caspase-3, type III procollagen (PCIII), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) mRNA expressions in lung tissue, as well as lung and distal organ epithelial cell apoptosis in an experimental model of sepsis-induced ALI.


Positive_regulation (induced) of Gene_expression (expressions) of vascular cell adhesion molecule in epithelial cell associated with adult respiratory distress syndrome, apoptosis, sepsis and adhesions
10) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.70 Pain Relevance 0
, caspase-3, type III procollagen (PCIII), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) mRNA expressions in lung tissue, as well as lung and distal organ epithelial cell apoptosis in an experimental model of sepsis-induced ALI.


Positive_regulation (induced) of Gene_expression (expressions) of VCAM in epithelial cell associated with adult respiratory distress syndrome, apoptosis, sepsis and adhesions
11) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.68 Pain Relevance 0
Furthermore, hypervolemia was associated with alveolar and endothelium damage as well as increased mRNA expression of IL-6, VCAM-1 and ICAM-1 in lung tissue.

• RMs reduced alveolar collapse regardless of volemic status. • During hypervolemia, RMs improved oxygenation and lung mechanics at the expense of alveolar capillary membrane damage, increased edema, and higher gene expression of inflammatory and fibrogenic mediators.

Positive_regulation (increased) of Gene_expression (expression) of VCAM in lung associated with pressure and volume under development, pressure volume 2 under development, inflammation and shock
12) Confidence 0.39 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.81 Pain Relevance 0.08
Additionally, VCAM-1 and ICAM-1 mRNA expressions were elevated in HYPER group suggesting endothelial activation due to vascular mechanical stretch.
Positive_regulation (elevated) of Gene_expression (expressions) of VCAM
13) Confidence 0.39 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.75 Pain Relevance 0.08
VCAM-1 and ICAM-1 expressions were also higher in HYPO compared with NORMO, reduced after RMs in HYPO, but augmented in NORMO group.
Positive_regulation (higher) of Gene_expression (expressions) of VCAM associated with pressure volume 2 under development
14) Confidence 0.39 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.49 Pain Relevance 0
VCAM-1 and ICAM-1 expressions were also higher in HYPO compared with NORMO, reduced after RMs in HYPO, but augmented in NORMO group.
Positive_regulation (augmented) of Gene_expression (expressions) of VCAM associated with pressure volume 2 under development
15) Confidence 0.39 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.53 Pain Relevance 0
Bone marrow cells implantation induced angiogenesis in a rat ischemic heart model as a result of increase of the levels of vascular endothelial growth factor, vascular cell adhesion molecule, interleukin-1, and tumor necrosis factor-?.



Positive_regulation (increase) of Gene_expression (levels) of vascular cell adhesion molecule in heart associated with necrosis, cancer and adhesions
16) Confidence 0.34 Published 2008 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2414821 Disease Relevance 0.79 Pain Relevance 0.16
The data also showed that NF-kappaB activation and its associated gene expressions, such as COX-2, iNOS, VCAM-1 and ICAM-1, were all suppressed by the low dose aspirin supplementation through the inhibition of phosphorylation and degradation of IkappaBalpha via the NIK/IKK pathway.
Positive_regulation (activation) of Gene_expression (expressions) of VCAM-1 associated with aspirin
17) Confidence 0.31 Published 2006 Journal Mech. Ageing Dev. Section Abstract Doc Link 16310244 Disease Relevance 0.61 Pain Relevance 0.59
Following removal of VP-16 from the culture, p65 and p50 nuclear profiles approximated those of untreated stromal cells, and VCAM-1 protein expression was restored.
Positive_regulation (restored) of Gene_expression (expression) of VCAM-1 in stromal cells
18) Confidence 0.30 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.13 Pain Relevance 0.03
The serum levels of sICAM-1, sVCAM-1 were markedly elevated in patients with acute myocardial infarction, unstable angina pectoris and stable heart disease compared to control group (p < 0.001, p < 0.004, p < 0.0002 for sICAM-1, p < 0.007, p < 0.003, p < 0.004 for sVCAM-1).
Positive_regulation (elevated) of Gene_expression (levels) of sVCAM-1 in heart associated with angina, heart disease and myocardial infarction
19) Confidence 0.24 Published 2003 Journal Prz. Lek. Section Abstract Doc Link 14750416 Disease Relevance 1.73 Pain Relevance 0.58
Soluble E-selectin, ICAM-1 and VCAM-1 levels in systemic and coronary circulation in patients with variant angina.
Positive_regulation (circulation) of Gene_expression (levels) of VCAM-1 associated with angina
20) Confidence 0.24 Published 1997 Journal Cardiovasc. Res. Section Title Doc Link 9415270 Disease Relevance 0.38 Pain Relevance 0.19

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