INT49108

Context Info Confidence 0.43 First Reported 1995 Last Reported 2007 Negated 2 Speculated 0 Reported most in Abstract Documents 6 Total Number 7 Disease Relevance 6.02 Pain Relevance 0.35

Anatomy Link Frequency bone marrow 2 macrophage 1 colon 1 TP53TG3 (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 4 99.12 imagery 1 79.56 headache 1 73.56 Pain 2 71.84 Inflammation 2 25.00

Disease Link Frequency Relevance Heat Herpes Simplex Virus 1 100.00 Esophageal Cancer 3 99.60 Colon Cancer 3 98.64 Cancer 56 97.72 Brain Tumor 2 97.48 Recurrence 19 96.36 Hepatocellular Cancer 4 95.76 Hepatitis 2 95.56 Death 6 95.24 Breast Cancer 50 94.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Analysis of the p53 gene with appropriate mutation detection methodology markedly improves the prediction of early recurrence, treatment failure, and death in breast cancer patients.

Gene_expression (Analysis) of p53 gene associated with breast cancer, death and recurrence

1) Confidence 0.43 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 10719728 Disease Relevance 0.80 Pain Relevance 0.10

Retrovirally expressed interleukin-2 gene, granulocyte macrophage-colony stimulating factor gene, herpes simplex virus-thymidine kinase gene and p53 gene in human esophageal cancer cells showed antitumor effects in a nude mice xenotransplant model.

Gene_expression (expressed) of p53 gene in macrophage associated with herpes simplex virus and esophageal cancer

2) Confidence 0.41 Published 2003 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 12894708 Disease Relevance 0.57 Pain Relevance 0.07

Analysis revealed no mutations of the VHL gene in 5 regions, exon 5-8 of the p53 gene, exon 1-2 of the p16 gene and exon 5,6 and 8 of the PTEN gene.

Gene_expression (exon) of p53 gene

3) Confidence 0.16 Published 2005 Journal Med. J. Malaysia Section Abstract Doc Link 16379193 Disease Relevance 0.59 Pain Relevance 0.11

A point mutation at codon 12 of the K-ras gene was found, while no alterations were noted in the p53 gene, whose mutations are frequent in colon cancers.

Neg (no) Gene_expression (noted) of p53 gene in colon associated with colon cancer

4) Confidence 0.11 Published 1998 Journal J. Gastroenterol. Section Abstract Doc Link 9658320 Disease Relevance 0.75 Pain Relevance 0.07

The genes involved and the mutations necessary for hepatic carcinogenesis are unknown, with the sole exception of the p53 gene, which is probably a late phenomenon.

Neg (exception) Gene_expression (exception) of p53 gene

5) Confidence 0.02 Published 1995 Journal Gastroenterologist Section Abstract Doc Link 7538016 Disease Relevance 1.57 Pain Relevance 0

Other prognostic and predictive factors have been studied in an effort to explain this phenomenon, some of which are more relevant than others: HER-2/neu gene amplification and protein expression, expression of other members of the epithelial growth factor receptor family, S phase fraction, DNA ploidy, p53 gene mutations, cyclin E, p27 dysregulation, the presence of tumor cells in the circulation or bone marrow, and perineural and lymphovascular space invasion.

Gene_expression (expression) of p53 gene in bone marrow associated with cancer

6) Confidence 0.01 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17993229 Disease Relevance 0.87 Pain Relevance 0

Other prognostic and predictive factors have been studied in an effort to explain this phenomenon, some of which are more relevant than others: HER-2/neu gene amplification and protein expression, expression of other members of the epithelial growth factor receptor family, S phase fraction, DNA ploidy, p53 gene mutations, cyclin E, p27 dysregulation, the presence of tumor cells in the circulation or bone marrow, and perineural and lymphovascular space invasion.

Gene_expression (expression) of p53 gene in bone marrow associated with cancer

7) Confidence 0.01 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17993229 Disease Relevance 0.87 Pain Relevance 0

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