INT4911

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Context Info
Confidence 0.22
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.89
Pain Relevance 6.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
spinal cord 2
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 582 100.00 Very High Very High Very High
Spinal cord 11 99.68 Very High Very High Very High
cytokine 20 96.40 Very High Very High Very High
Potency 6 94.00 High High
Calcitonin gene-related peptide 3 88.96 High High
antagonist 2 87.92 High High
Neuropeptide 5 86.52 High High
Inflammation 15 85.40 High High
antinociception 2 79.44 Quite High
excitatory amino acid 1 77.04 Quite High
Disease Link Frequency Relevance Heat
Immunization 4 100.00 Very High Very High Very High
Targeted Disruption 42 99.54 Very High Very High Very High
Granuloma 92 95.88 Very High Very High Very High
Infection 12 85.76 High High
INFLAMMATION 12 85.40 High High
Bronchospasm 1 75.00 Quite High
Cyst 12 65.52 Quite High
Neurocysticercosis 8 64.80 Quite High
Asthma 1 57.56 Quite High
Disease 2 44.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with [D-Pro2,D-Phe7]SP(1-7), an inhibitor of SP NH2-terminal binding, blocked the potentiative effect of SP(1-7) as well as the sensitization to repeated injections of KA.
Negative_regulation (inhibitor) of SP Binding (binding) of associated with substance p
1) Confidence 0.22 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1281498 Disease Relevance 0 Pain Relevance 0.98
As SP(5-11) did not down-regulate NK-1 binding, activation of NK-1 sites does not appear necessary or sufficient for down-regulation of SP binding.
Negative_regulation (regulation) of SP Binding (binding) of associated with substance p
2) Confidence 0.20 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.12
However, injection of 1 nmol of SP(1-7) decreased the Bmax of [3H]SP binding in the spinal cord at 6 h after its injection just as this dose of SP decreased the Bmax at 24 h.
Negative_regulation (decreased) of SP Binding (binding) of in spinal cord associated with spinal cord and substance p
3) Confidence 0.20 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.21
Therefore, it may be possible that in the NK1-knockout mice, the synergistic lack of activity of both SP and hemokinin may have resulted in lower IL-1?
Negative_regulation (lack) of SP Binding (activity) of associated with targeted disruption and substance p
4) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.52 Pain Relevance 0.57
The concentration of fluorescent analog required to inhibit the binding of radiolabeled SP by 50 % (IC50) was calculated from the binding studies.
Negative_regulation (inhibit) of SP Binding (binding) of associated with substance p
5) Confidence 0.05 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.76
Sigmoidal (Hill, 3 parameter) regression was then performed on the data to determine the IC50, the concentration of fluorescent analog required to inhibit the binding of radiolabeled SP by 50 %, for each SP analog.


Negative_regulation (inhibit) of SP Binding (binding) of associated with substance p
6) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.50
Whether passive immunization with alpha-SP Ab prevented bronchospastic responses to SP and NKA (i.v.), in vivo, was determined in groups of anesthetized guinea-pigs by recording pulmonary flow resistance (RL) and dynamic pulmonary elastance (EL).
Negative_regulation (prevented) of SP Binding (immunization) of associated with immunization and substance p
7) Confidence 0.03 Published 1995 Journal Life Sci. Section Abstract Doc Link 7541500 Disease Relevance 0.37 Pain Relevance 1.03

General Comments

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