INT49110

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2010
Negated 5
Speculated 12
Reported most in Abstract
Documents 46
Total Number 59
Disease Relevance 13.57
Pain Relevance 30.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
neurons 5
spinal 3
spinal cord 3
brain 2
spine 2
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 644 100.00 Very High Very High Very High
antagonist 282 100.00 Very High Very High Very High
Gabapentin 104 100.00 Very High Very High Very High
intrathecal 84 100.00 Very High Very High Very High
agonist 35 100.00 Very High Very High Very High
dorsal root ganglion 8 100.00 Very High Very High Very High
Dynorphin 14 99.98 Very High Very High Very High
nMDA receptor 320 99.96 Very High Very High Very High
Dopamine 20 99.92 Very High Very High Very High
withdrawal 37 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 174 100.00 Very High Very High Very High
Ganglion Cysts 27 100.00 Very High Very High Very High
Neuropathic Pain 58 99.32 Very High Very High Very High
Depression 219 99.18 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

81 99.08 Very High Very High Very High
Affective Disorder 5 98.72 Very High Very High Very High
Alzheimer's Dementia 2 98.72 Very High Very High Very High
Hyperalgesia 66 98.60 Very High Very High Very High
Heart Rate Under Development 163 98.48 Very High Very High Very High
Stress 200 98.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deafferentation-induced regulation of AMPA receptors in the spinal cord of the adult rat.
Regulation (regulation) of AMPA in spinal cord associated with spinal cord and deafferentation
1) Confidence 0.61 Published 1999 Journal Somatosens Mot Res Section Title Doc Link 10355882 Disease Relevance 0.19 Pain Relevance 0.70
We investigated the effects of AMPA-receptor blockade in the rostral ventrolateral medulla (RVLM) on cardiovascular responses and extracellular concentrations of glutamate during two different types of stimuli that activate peripheral Adelta - and C-fiber polymodal nociceptors using anesthetized rats.
Spec (investigated) Regulation (effects) of AMPA-receptor in nociceptors associated with c fibre, glutamate, rostral ventrolateral medulla, nociceptor and adelta
2) Confidence 0.45 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11207065 Disease Relevance 0 Pain Relevance 0.41
The effects of the AMPA-receptor antagonists NBQX and GYKI 52466 were compared with those of the NMDA-receptor channel blocker dizocilpine in two drug discrimination tests.
Regulation (effects) of AMPA-receptor associated with antagonist
3) Confidence 0.37 Published 1996 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8972552 Disease Relevance 0 Pain Relevance 0.41
Ketamine (10 microM) caused a 2-fold larger decrease in NMDA current than acetylcholine current, but did not affect AMPA current.
Neg (not) Regulation (affect) of AMPA associated with ketamine
4) Confidence 0.23 Published 1996 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9028586 Disease Relevance 0 Pain Relevance 0.49
The modulation of AMPA receptor may be related to the decrease of hyperalgesia evident 1 h after formalin injection, in spite of the increasing perioral inflammation evident later on and characteristic of the formalin model.
Regulation (modulation) of AMPA receptor associated with hyperalgesia, inflammation and eae
5) Confidence 0.23 Published 1999 Journal Neuroscience Section Abstract Doc Link 10188946 Disease Relevance 0.66 Pain Relevance 0.57
Most AMPA and kainate receptor-expressing DRG neurons were sensitive to capsaicin, suggesting involvement of these glutamate receptors in nociception.
Regulation (sensitive) of AMPA in neurons associated with nociception, dorsal root ganglion, qutenza and glutamate receptor
6) Confidence 0.22 Published 2004 Journal Neuroscience Section Abstract Doc Link 15489026 Disease Relevance 0.55 Pain Relevance 0.66
On the other hand, AMPA receptors are present in the superficial lamina of the dorsal horn and mediate excitatory transmission involving acute nociceptive inputs (24, 25).
Regulation (present) of AMPA in lamina associated with nociception, dorsal horn and superficial lamina
7) Confidence 0.22 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808611 Disease Relevance 0.83 Pain Relevance 1.26
To explore this possibility, we investigated changes in AMPA receptors in substantia gelatinosa of rats after section of the sciatic nerve.
Spec (investigated) Regulation (changes) of AMPA in sciatic nerve associated with substantia gelatinosa and sciatic nerve
8) Confidence 0.20 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9786215 Disease Relevance 0.18 Pain Relevance 0.45
The aim of this study was threefold: 1) to examine the effect of intrathecal gabapentin, NMDA antagonist (MK801) and AMPA antagonist (NBQX) in the rat formalin test, 2) to evaluate the consequence of gabapentin on the effect of MK801 or NBQX in acute nociception, and 3) to determine the spinally mediated antinociceptive interactions between gabapentin and MK801 or NBQX in the injury-induced hyperalgesia.


Spec (examine) Regulation (effect) of AMPA associated with nociception, hyperalgesia, antagonist, injury, antinociceptive, gabapentin and intrathecal
9) Confidence 0.19 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808611 Disease Relevance 1.35 Pain Relevance 1.77
Differential expression of GluR1 and GluR2 subunits suggests regulation of AMPA receptor subunit composition by presynaptic mechanism.
Regulation (regulation) of AMPA receptor subunit
10) Confidence 0.13 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18815255 Disease Relevance 0 Pain Relevance 0.17
Modulation of both AMPA- and NMDA-R currents in the nucleus accumbens is likely to play a major role in setting the cellular excitability in response to behaviourally relevant limbic inputs, and in regulating the plasticity of these responses.
Regulation (Modulation) of AMPA in nucleus accumbens associated with nucleus accumbens
11) Confidence 0.12 Published 2003 Journal Brain Res. Section Abstract Doc Link 12763622 Disease Relevance 0 Pain Relevance 0.74
The consolidation process involves the NMDA and AMPA receptors in both structures.
Regulation (involves) of AMPA
12) Confidence 0.12 Published 1996 Journal Chin J Physiol Section Abstract Doc Link 8955562 Disease Relevance 0 Pain Relevance 0.36
This study investigated the roles of NMDA and AMPA receptors in the amygdala and medial prefrontal cortex in formation and retrieval of affective memory.
Spec (investigated) Regulation (roles) of AMPA in cortex associated with amygdala
13) Confidence 0.12 Published 1996 Journal Chin J Physiol Section Abstract Doc Link 8955562 Disease Relevance 0 Pain Relevance 0.16
These changes in behaviour may reflect plastic changes requiring regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA) receptor function. 2.
Regulation (regulation) of AMPA
14) Confidence 0.10 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.37
In contrast to NMDA receptor antagonists' early ineffectiveness in suppressing morphine withdrawal, the AMPA receptor antagonist and the group II mGluR agonists were effective at all ages tested.
Regulation (effective) of AMPA receptor associated with nmda receptor antagonist, antagonist, agonist, withdrawal and morphine
15) Confidence 0.10 Published 2004 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 15380837 Disease Relevance 0 Pain Relevance 1.56
We also examined the effect of CX717 on AMPA receptor currents in XII MNs.
Spec (examined) Regulation (effect) of AMPA receptor
16) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0 Pain Relevance 0.37
The effects of combined AMPA/NMDA receptor blockade in the region containing CVPN on HR and baroreflex function are shown in Figure 3C.
Regulation (effects) of AMPA associated with nmda receptor
17) Confidence 0.08 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2964734 Disease Relevance 0 Pain Relevance 0.32
We examined the role of glutamatergic transmission in these reflexes by testing effects of the N-methyl-D-aspartate (NMDA)-receptor antagonist 2-amino-5-phosphonopentanoic acid (AP-5) and of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquinone (NBQX) on the reflex hypertension caused by colon distension.
Regulation (effects) of AMPA in colon associated with antagonist and hypertension
18) Confidence 0.07 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9321815 Disease Relevance 0.36 Pain Relevance 0.38
However, in experiments performed in the presence of the rapidly dissociating AMPA receptor antagonist kynurenate (therefore unaffected by AMPA receptor saturation) there was considerably less depression (Figure 6B in same paper), suggesting a postsynaptic contribution to the phenomenon.
Neg (unaffected) Regulation (unaffected) of AMPA associated with depression and antagonist
19) Confidence 0.06 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.43 Pain Relevance 0.31
As a control for the effectiveness of AMPA receptor blockade, the influence of the AMPA receptor antagonist CNQX on postsynaptic responses was monitored.
Regulation (influence) of AMPA receptor associated with antagonist
20) Confidence 0.05 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC516773 Disease Relevance 0.26 Pain Relevance 0.05

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