INT49112

Context Info Confidence 0.00 First Reported 1995 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.06 Pain Relevance 0.06

extracellular space (SERPINB2, PLAU) extracellular region (SERPINB2, PLAU) plasma membrane (SERPINB2, PLAU) peptidase activity (PLAU) signal transduction (PLAU) Golgi apparatus (SERPINB2)

SERPINB2 (Homo sapiens) PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 1 64.80 tolerance 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Cancer 30 100.00 Metastasis 30 87.12 Recurrence 2 84.64 Breast Cancer 1 82.24 Stomach Cancer 1 76.72 Skin Cancer 47 53.60 Alzheimer's Dementia 1 19.68 Ovarian Cancer 1 10.64 Mouth Cancer 4 5.00 Disease 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

High levels of urokinase in primary tumors are also associated with a poorer prognosis, as well as plasminogen inactivator inhibitor PAI II, which plays a crucial role in tumor growth.

PAI II Binding (associated) of urokinase associated with cancer

1) Confidence 0.00 Published 1995 Journal Surg. Today Section Abstract Doc Link 7538364 Disease Relevance 1.55 Pain Relevance 0.06

Several other proteins, fibrin, uPA receptor (uPAR), and two main PA inhibitors, PAI-1 and PAI-2, are also important in this process.

PAI-2 Binding (receptor) of uPA

2) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 0.51 Pain Relevance 0

General Comments

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