INT49128

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Context Info
Confidence 0.63
First Reported 1995
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 35
Total Number 40
Disease Relevance 23.48
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1R) plasma membrane (IGF1R)
Anatomy Link Frequency
arms 3
TFK-1 3
Caco-2 1
pancreatic ducts 1
microglia 1
IGF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 99.88 Very High Very High Very High
antagonist 7 92.96 High High
palliative 31 91.56 High High
Root ganglion neuron 1 90.84 High High
Neuritis 5 88.72 High High
Inflammation 445 87.56 High High
Bile 42 87.32 High High
Spinal cord 2 77.08 Quite High
cINOD 7 71.44 Quite High
headache 7 63.68 Quite High
Disease Link Frequency Relevance Heat
Cancer 1649 99.98 Very High Very High Very High
Pancreatitis 4 99.88 Very High Very High Very High
Pancreatic Cancer 15 99.80 Very High Very High Very High
Cholangiocarcinoma 518 99.68 Very High Very High Very High
Lung Cancer 147 99.66 Very High Very High Very High
Apoptosis 215 99.28 Very High Very High Very High
Malignant Neoplastic Disease 81 98.92 Very High Very High Very High
Gastrointestinal Stromal Tumor 208 98.44 Very High Very High Very High
Adenocarcinoma 54 98.12 Very High Very High Very High
Prostate Cancer 175 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma.
Gene_expression (Coexpression) of IGF-1R associated with adenocarcinoma
1) Confidence 0.63 Published 2003 Journal Dig. Dis. Sci. Section Title Doc Link 14627343 Disease Relevance 0.61 Pain Relevance 0
It has been postulated that c-Src may induce transformation by causing the overexpression of the insulinlike growth factor-1 receptor (IGF-1R) in pancreatic tumor cell lines.
Gene_expression (overexpression) of IGF-1R associated with pancreatic cancer
2) Confidence 0.63 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14627343 Disease Relevance 0.51 Pain Relevance 0
IGF-1R staining was low (Alled score 2-4) in 2 cases and negative in 1.
Neg (negative) Gene_expression (negative) of IGF-1R
3) Confidence 0.63 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14627343 Disease Relevance 0.88 Pain Relevance 0.08
Up-regulation of COX-2 expression by IGF-II is mediated through activation of IGF-I receptor because: (i) treatment of Caco-2 cells with a blocking antibody to the IGF-I receptor inhibits COX-2 mRNA expression; (ii) transfection of Caco-2 cells with a dominant negative IGF-I receptor reduces COX-2 expression and activity.
Gene_expression (transfection) of IGF-I receptor in Caco-2
4) Confidence 0.59 Published 2000 Journal Oncogene Section Abstract Doc Link 11114729 Disease Relevance 0.44 Pain Relevance 0.07
Normal pancreatic ducts as well as areas of chronic pancreatitis were negative for IGF-1R.
Neg (negative) Gene_expression (negative) of IGF-1R in pancreatic ducts associated with chronic pancreatitis
5) Confidence 0.55 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14627343 Disease Relevance 0.81 Pain Relevance 0.10
In contrast, there is not a sex difference in expression of the IGF-1 receptor according to the present microarray study and a previous study in which IGFR gene expression was determined by RT-PCR analysis [10].
Gene_expression (expression) of IGFR
6) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.15 Pain Relevance 0
DROSHA, ITGB4, IGF1R, MT1X, MT1E, BRAF) was likewise affected by Par-4 overexpression in HT29 cells (Figure 2A; see Additional file 2 for gene symbols and their corresponding gene names).


Gene_expression (overexpression) of IGF1R
7) Confidence 0.44 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.53 Pain Relevance 0
Seven (23%) tumors expressed IGF1R (Additionnal file 1-Tables S8-S9A); all of them also expressed ERBB2 (all HerceptTest 3+).
Gene_expression (expressed) of IGF1R associated with cancer
8) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.35 Pain Relevance 0
IGF1R and EGFR expression in ERBB2-amplified tumors
Gene_expression (expression) of IGF1R associated with cancer
9) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.24 Pain Relevance 0
IGF1R+ or EGFR+ ERBB2-amplified tumors were all ERBB2+ while IGF1R and EGFR were rarely coexpressed.
Gene_expression (coexpressed) of IGF1R associated with cancer
10) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.81 Pain Relevance 0.06
Expression levels of insulin-like growth factor type 1 receptor (IGF1R), epidermal growth factor receptor (EGFR), and ERBB2 have been linked to clinical outcome in breast and other solid tumors [44].
Gene_expression (Expression) of insulin-like growth factor type 1 receptor associated with solid tumor
11) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.32 Pain Relevance 0
Associations of EGFR, ERBB2, pERBB2, FOXA1 and IGF1R expression with histoclinical features were assessed with Spearman's rank-correlation test or Mann-Whitney U test, as appropriate.
Gene_expression (expression) of IGF1R
12) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.62 Pain Relevance 0
IGF1R expression was confirmed in the four CC cell lines tested by RT-PCR and IHC.
Gene_expression (expression) of IGF1R associated with cholangiocarcinoma
13) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.05 Pain Relevance 0.04
EGFR, HGFR, IGF1R, IGF2R and VEGFR1 were detected in all four cell lines (figure 2B).
Gene_expression (detected) of IGF1R
14) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 0.47 Pain Relevance 0
Therefore, the aim of this study was to determine the expression of EGFR, IGF1R, IGF2R, HGFR and VEGFR1-3 in four human CC cell lines.
Spec (determine) Gene_expression (expression) of IGF1R associated with cholangiocarcinoma
15) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.07 Pain Relevance 0
Increased expression of IGF1R promotes ligand-dependent malignant transformation in various cell systems [48].
Gene_expression (expression) of IGF1R associated with malignant neoplastic disease
16) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.35 Pain Relevance 0.05
Expression of EGFR (epithelial growth factor receptor), HGFR (hepatocyte growth factor receptor) IGF1R (insulin-like growth factor 1 receptor), IGF2R (insulin-like growth factor 2 receptor) and VEGFR1-3 (vascular endothelial growth factor receptor 1-3) were examined in four human CC cell lines (EGI-1, HuH28, OZ and TFK-1).
Gene_expression (Expression) of IGF1R in TFK-1 associated with cholangiocarcinoma
17) Confidence 0.35 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2896958 Disease Relevance 0.78 Pain Relevance 0.14
Expression of EGFR (epithelial growth factor receptor), HGFR (hepatocyte growth factor receptor) IGF1R (insulin-like growth factor 1 receptor), IGF2R (insulin-like growth factor 2 receptor) and VEGFR1-3 (vascular endothelial growth factor receptor 1-3) were examined in four human CC cell lines (EGI-1, HuH28, OZ and TFK-1).
Gene_expression (Expression) of insulin-like growth factor 1 receptor in TFK-1 associated with cholangiocarcinoma
18) Confidence 0.35 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2896958 Disease Relevance 0.84 Pain Relevance 0.14
Alvaro et. al. reported that IGF1R is expressed in the CC cell lines HuH-28, TFK-1 and Mz-ChA-1 [47] which supports our finding.
Gene_expression (expressed) of IGF1R in TFK-1 associated with cholangiocarcinoma
19) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.15 Pain Relevance 0.05
Expression levels of insulin-like growth factor type 1 receptor (IGF1R), epidermal growth factor receptor (EGFR), and ERBB2 have been linked to clinical outcome in breast and other solid tumors [44].
Gene_expression (Expression) of IGF1R associated with solid tumor
20) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.32 Pain Relevance 0

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