INT49129

Context Info Confidence 0.69 First Reported 1994 Last Reported 2010 Negated 3 Speculated 0 Reported most in Abstract Documents 35 Total Number 35 Disease Relevance 28.78 Pain Relevance 10.38

cytosol (GFAP) extracellular matrix organization (GFAP) cytoplasm (GFAP)

Anatomy Link Frequency neuronal 3 astrocyte 3 LGN 2 macrophage 1 sensory neurons 1 GFAP (Homo sapiens)

Pain Link Frequency Relevance Heat substance P 1 100.00 Enkephalin 1 100.00 qutenza 22 99.98 calcitonin gene related peptide 1 99.52 Sciatic nerve 4 99.44 Neuropathic pain 5 99.42 antagonist 20 99.28 Morphine 13 99.20 Lasting pain 6 99.10 Spinal cord 17 99.00

Disease Link Frequency Relevance Heat Ependymoma 41 99.84 Injury 110 99.82 Ocular Hypertension 160 99.80 Hypertrophy 1 99.76 Cancer 79 99.72 Brain Injury 74 99.68 Disease 172 99.56 Neuropathic Pain 7 99.42 Creutzfeldt Jakob Disease 4 99.12 Pain 13 99.10

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, capsaicin increased the transcription levels of glial fibrillary acidic protein (GFAP) and neuronal microtubule-associated protein 2ab (MAP2ab).

Positive_regulation (increased) of glial fibrillary acidic protein in neuronal associated with qutenza

1) Confidence 0.69 Published 2008 Journal Life Sci. Section Abstract Doc Link 18405923 Disease Relevance 0.49 Pain Relevance 0.85

The most common pattern was found in 50% (11 out of 22) of the CRPS patients and consisted of; elevated IL-6, low levels of IL-4 or IL-10, increased GFAP or MCP1 and increases in at least two of the following markers NO metabolites, calcium or glutamate.

Positive_regulation (increased) of GFAP associated with complex regional pain syndromes and glutamate

2) Confidence 0.67 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17129705 Disease Relevance 0.97 Pain Relevance 0.64

Moreover, capsaicin increased the transcription levels of glial fibrillary acidic protein (GFAP) and neuronal microtubule-associated protein 2ab (MAP2ab).

Positive_regulation (increased) of GFAP in neuronal associated with qutenza

3) Confidence 0.67 Published 2008 Journal Life Sci. Section Abstract Doc Link 18405923 Disease Relevance 0.49 Pain Relevance 0.85

This tumor-induced injury of sensory nerve fibers is accompanied by an increase in ongoing and movement-evoked pain behaviors, an upregulation of activating transcription factor 3 (ATF3) and galanin by sensory neurons that innervate the tumor-bearing femur, upregulation of glial fibrillary acidic protein (GFAP) and hypertrophy of satellite cells surrounding sensory neuron cell bodies within the ipsilateral dorsal root ganglia (DRG), and macrophage infiltration of the DRG ipsilateral to the tumor-bearing femur.

Positive_regulation (upregulation) of GFAP in sensory neurons associated with pain, hypertrophy, cancer and injury

4) Confidence 0.67 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15817267 Disease Relevance 1.73 Pain Relevance 0.79

Immunohistochemically, the tumor cells proved positive for S-100, NSE, GFAP, MBP, chromogranin A and synaptophysin, and negative for CEA, keratin, HMB-45, G-CSF, and GM-CSF.

Positive_regulation (positive) of GFAP associated with cancer

5) Confidence 0.49 Published 2005 Journal Pathol. Res. Pract. Section Abstract Doc Link 15991844 Disease Relevance 1.29 Pain Relevance 0.25

Although, metastatic carcinomas are positive for cytokeratins, these are consistently negative for GFAP.

Positive_regulation (negative) of GFAP associated with carcinoma

6) Confidence 0.49 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2584038 Disease Relevance 2.12 Pain Relevance 0

The cells presented positive for GFAP, S-100 protein, vimentin, Nestin and neurofilament, and dotlike positive for epithelial membrane antigen, but negative for Syn and NeuN.

Positive_regulation (positive) of GFAP

7) Confidence 0.49 Published 2008 Journal Neuropathology Section Abstract Doc Link 18312548 Disease Relevance 0.76 Pain Relevance 0.08

By IMHC, the cells were positive for inhibin, melan-A, and synaptophysin, and negative for GFAP, EMA, cytokeratins, S-100, HMB-45, and chromogranin.

Positive_regulation (negative) of GFAP

8) Confidence 0.49 Published 2004 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 15306940 Disease Relevance 0.89 Pain Relevance 0.15

Indeed, as seen for chronic morphine and cocaine treatments, we show here that chronic ethanol treatment increased levels of tyrosine hydroxylase and glial fibrillary acidic protein immunoreactivity, and decreases levels of neurofilament protein immunoreactivity, in the VTA.

Positive_regulation (increased) of glial fibrillary acidic protein associated with ventral tegmentum, cocaine and morphine

9) Confidence 0.49 Published 1995 Journal Synapse Section Abstract Doc Link 8869159 Disease Relevance 0 Pain Relevance 0.81

IL-6, IL-8, MCP-1, tau, S100beta, and glial fibrillary acidic protein (GFAP) were elevated in a severity-dependent fashion.

Positive_regulation (elevated) of GFAP

10) Confidence 0.45 Published 2010 Journal J. Neurotrauma Section Abstract Doc Link 20038240 Disease Relevance 1.16 Pain Relevance 0.39

Although a significant increase in GFAP could be observed in CJD as well, this was not as pronounced as in AD [46].

Positive_regulation (increase) of GFAP associated with creutzfeldt jakob disease and disease

11) Confidence 0.38 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 1.33 Pain Relevance 0.04

In the OHT animals, GFAP, but not MAC-1, immunoreactivity was elevated in spatial register with the treated eye layers of LGN and V1.

Positive_regulation (elevated) of GFAP in LGN associated with ocular hypertension

12) Confidence 0.38 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2773743 Disease Relevance 1.34 Pain Relevance 0.10

GFAP and MAC-1 immunoreactivities were elevated in spatial register with the treated eye layers of the LGN and V1 in ONT animals.

Positive_regulation (elevated) of GFAP in LGN associated with optic nerve injuries

13) Confidence 0.38 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2773743 Disease Relevance 1.25 Pain Relevance 0.10

While S100B has been demonstrated to have extracranial sources, serum GFAP levels are not increased by non-head injuries [46,49].

Neg (not) Positive_regulation (increased) of GFAP in head associated with brain injury

14) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2853529 Disease Relevance 1.28 Pain Relevance 0.39

In accordance with a previous report [45], research within cNEUPRO found glial fibrillary acidic protein (GFAP), a marker for astrogliosis, to be increased in CSF of AD and sporadic Creutzfeldt-Jacob Disease (sCJD) patients.

Positive_regulation (increased) of acidic protein associated with disease

15) Confidence 0.33 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 1.15 Pain Relevance 0.03

In addition, these cells were immunoreactive to glial acidic fibrillary protein, growth-associated protein (GAP-43), and vimentin, further suggesting that dental pulp contains a population of cells with membrane properties similar to neuronal satellite cells.

Positive_regulation (immunoreactive) of fibrillary protein in neuronal

16) Confidence 0.32 Published 1994 Journal Arch. Oral Biol. Section Abstract Doc Link 7945020 Disease Relevance 0 Pain Relevance 0.13

ECM: Extracellular (matrix); (ExpG): experimental glaucoma; (GEO): Gene Expression Omnibus; (GFAP): glial fibrillary acidic protein; (LC): lamina cribrosa; (ONH): optic nerve head; (POAG): primary openangle glaucoma; (PCR): polymerase chain reaction; (qRT-PCR): quantitative real-time PCR; (RP): Rank Products; (RNFL): retinalnerve fiber layer; (SAM): Significance Analysis of Microarrays; (VCC): variable corneal compensation.

Positive_regulation (fibrillary) of acidic protein in lamina associated with glaucoma

17) Confidence 0.31 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.54 Pain Relevance 0

Astrocytes upregulate glial fibrillary acidic protein (GFAP), but not insulin-like growth factor-I (IGF-I) during experimental autoimmune neuritis (EAN).

Neg (not) Positive_regulation (upregulate) of GFAP in Astrocytes associated with experimental autoimmune neuritis and neuritis

18) Confidence 0.27 Published 1995 Journal Brain Pathol. Section Title Doc Link 7539325 Disease Relevance 0.51 Pain Relevance 0.53

Relative levels of GFAP mRNA and peptide were highest in the lumbar spinal cord 4-10 d following T cell transfer and significant GFAP elevations were still present after three weeks.

Positive_regulation (elevations) of GFAP in T cell associated with spinal cord

19) Confidence 0.24 Published 1995 Journal Brain Pathol. Section Abstract Doc Link 7539325 Disease Relevance 0.48 Pain Relevance 0.49

These induced cells were found to be positive for neural markers such as Nestin, GFAP, NeuN, BT, Neurofilament (NF-70), and TH [Figures 9–11].

Positive_regulation (positive) of GFAP in neural

20) Confidence 0.23 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0.09 Pain Relevance 0

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